| Project/Area Number |
22591722
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KADOI Yuji 群馬大学, 医学部, 准教授 (10292591)
SAITO Shigeru 群馬大学, 大学院・医学系研究科, 教授 (40251110)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | バソプレッシン / 敗血症 / 心筋 / 循環管理 / vasopressin / エンドトキシン活性 / 心筋収縮能 |
|---|
| Research Abstract |
Relation of vasopressin and myocardial contraction function changes were investigated in septic shock patients in the ICU and sepsis animal models. In sepsis animal models, contraction of ventricular resection and concentration of the Ca2+ in the cells were measured. Also, in patients, the cardiac changes were investigated with 3D esophageal echo. Both of the investigation, the relation of myocardial contraction function changes and vasopressin were not observed. However in a septic animal model, some animal suggested that the change of the cardiac muscle contraction depended on the vasopressin concentration.
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