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Effect of anesthetic agents on inhibitory or excitatory transmission in the substantia gelatinosa revealed by in vivo patch clamp recordings

Research Project

Project/Area Number 22591736
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionKyushu University

Principal Investigator

YAMAURA Ken  九州大学, 大学病院, 准教授 (70264041)

Co-Investigator(Kenkyū-buntansha) YAMAURA Ken  熊本保健科学大学, 生命科学研究科, 教授 (10140641)
SHIOKAWA Hiroaki  九州大学, 大学病院, 助教 (30572490)
KARASHIMA Yuji  九州大学, 大学病院, 助教 (80380434)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Keywords疼痛管理学 / 疼痛 / 麻酔 / インビボパッチクランプ / in vivoパッチクランプ / 脊髄膠様質細胞 / GABAA受容体 / NMDA受容体 / ケタミン / インビボパッチクランブ / 脊髄膠様質 / 抑制性細胞 / 興奮性細胞 / GABA_A受容体 / ペンゾジアゼピン
Research Abstract

The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. Using this method, transmission between neurons can be analyzed in detail. In this project, we observed the responses evoked by tactile stimulation in the spinal cord and analyzed the effect of remifentanil which is known as opioid on nociceptive transmission by invivo patch clamp recordings.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2010

All Presentation (6 results)

  • [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats2012

    • Author(s)
      塩川 浩輝、山浦 健、辛島 裕士、外須美夫
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      米国、ワシントンD.C
    • Year and Date
      2012-10-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats2012

    • Author(s)
      塩川 浩輝、古賀 公平、山浦 健、辛島裕士、外 須美夫
    • Organizer
      European Society of Anesthesiology annual meeting, Euroanaesthesia 2012
    • Place of Presentation
      フランス、パリ
    • Year and Date
      2012-06-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Analysis of analgesic effect of propofol by in-vivo patch clamp recordings from the somatosensory cortex of rats2012

    • Author(s)
      Hiroaki Shiokawa, Kohei Koga, Ken Yamaura, Yuji Karashima, Sumio Hoka, Megumu Yoshimura
    • Organizer
      European Society of Anesthesiology annual meeting, Euroanaesthesia 2012
    • Place of Presentation
      パリ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Evaluation of analgesic and hypnotic effects of pentobarbital and propofol using in vivo patch clamp recording from rat somatosensory cortex2012

    • Author(s)
      Hiroaki Shiokawa, Ken Yamaura, Yuji Karashima, Sumio Hoka and Megumu Yoshimura
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      ワシントンDC
    • Related Report
      2012 Annual Research Report
  • [Presentation] Differential NR2 Subunit Composition of NMDA receptors between Inhibitory and Ecxitatory Interneurons of the Mouse Spinal Dorsal Horn2010

    • Author(s)
      塩川 浩輝、Chi-Kun Tong、外 須美夫、Amy B. MacDermott
    • Organizer
      Annual Meeting of the American Society of Anesthesiologists
    • Place of Presentation
      米国、サンディエゴ
    • Year and Date
      2010-10-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Differential NR2 Subunit Composition of NMDA receptors between Inhibitory and Ecxitatory Interneurons of the Mouse Spinal Dorsal Horn.2010

    • Author(s)
      塩川浩輝
    • Organizer
      Anesthesiology 2010
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2010-10-17
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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