Effect of anesthetic agents on inhibitory or excitatory transmission in the substantia gelatinosa revealed by in vivo patch clamp recordings
| Project/Area Number |
22591736
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kyushu University |
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Principal Investigator |
YAMAURA Ken 九州大学, 大学病院, 准教授 (70264041)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAURA Ken 熊本保健科学大学, 生命科学研究科, 教授 (10140641)
SHIOKAWA Hiroaki 九州大学, 大学病院, 助教 (30572490)
KARASHIMA Yuji 九州大学, 大学病院, 助教 (80380434)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | 疼痛管理学 / 疼痛 / 麻酔 / インビボパッチクランプ / in vivoパッチクランプ / 脊髄膠様質細胞 / GABAA受容体 / NMDA受容体 / ケタミン / インビボパッチクランブ / 脊髄膠様質 / 抑制性細胞 / 興奮性細胞 / GABA_A受容体 / ペンゾジアゼピン |
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| Research Abstract |
The patch clamp technique is a laboratory technique in electrophysiology that allows the study of single or multiple ion channels in cells. Using this method, transmission between neurons can be analyzed in detail. In this project, we observed the responses evoked by tactile stimulation in the spinal cord and analyzed the effect of remifentanil which is known as opioid on nociceptive transmission by invivo patch clamp recordings.
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Report
(4 results)
Research Products
(6 results)
