| Project/Area Number |
22591744
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Yokohama City University |
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Principal Investigator |
OGAWA Ken-ichi 横浜市立大学, 附属病院, 准教授 (10233412)
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| Co-Investigator(Kenkyū-buntansha) |
SHINBORI Hironobu 横浜市立大学, 医学部, 講師 (60404993)
KAMIYA Yoshinori 横浜市立大学, 医学研究科, 客員講師 (90381491)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 術後疼痛 / 記憶学習 / 海馬 / 急性痛 / 忌避刺激 / 電気生理学 / 疼痛 / 海馬・扁桃体 / 術後鎮痛 |
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| Research Abstract |
The aim of this study is to clarify the impact of pain and its analgesia on memory and learning. We investigated the effects of acute postoperative pain on fear stimulus memories, one trial passive avoidance learning test was performed using a rat simple laparotomy model. We performed IA-conditioning to the rats 2 hours after the surgery and we conducted IA-test to 24 hours after surgery. Contrary to the expectations, latency to the entering black box had not changed in both groups. Furthermore, we compared the amount of GluA1 subunit of AMPA receptor, which is known to be involved in learning and memory in the hippocampus, in hippocampus synaptosome 24 hours after surgery and there was no difference between laparotomy group and control group. The results of this study suggested that postoperative acute pain may not directly affect the learning and memory disorders of perioperative period.
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