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Impact of pain on the learning and memory - Behavioral assessment and histological and physiological study in the central nervous system -

Research Project

Project/Area Number 22591744
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionYokohama City University

Principal Investigator

OGAWA Ken-ichi  横浜市立大学, 附属病院, 准教授 (10233412)

Co-Investigator(Kenkyū-buntansha) SHINBORI Hironobu  横浜市立大学, 医学部, 講師 (60404993)
KAMIYA Yoshinori  横浜市立大学, 医学研究科, 客員講師 (90381491)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords術後疼痛 / 記憶学習 / 海馬 / 急性痛 / 忌避刺激 / 電気生理学 / 疼痛 / 海馬・扁桃体 / 術後鎮痛
Research Abstract

The aim of this study is to clarify the impact of pain and its analgesia on memory and learning. We investigated the effects of acute postoperative pain on fear stimulus memories, one trial passive avoidance learning test was performed using a rat simple laparotomy model. We performed IA-conditioning to the rats 2 hours after the surgery and we conducted IA-test to 24 hours after surgery. Contrary to the expectations, latency to the entering black box had not changed in both groups. Furthermore, we compared the amount of GluA1 subunit of AMPA receptor, which is known to be involved in learning and memory in the hippocampus, in hippocampus synaptosome 24 hours after surgery and there was no difference between laparotomy group and control group. The results of this study suggested that postoperative acute pain may not directly affect the learning and memory disorders of perioperative period.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

Research Products

(3 results)

All 2013 Other

All Presentation (3 results)

  • [Presentation] Pharmacological Analysis for the 5-HT Receptors in Electrical Spinal Cord Stimulation for Neuropathic Pain in Rat2013

    • Author(s)
      Ayako Kobayashi, Yoshinori Kamiya, Toshiharu Tazawa, Takahiro Mihara, Yusuke Nakahashi, Hironobu Shinbori, Takahisa Goto
    • Organizer
      2013 Annual Meeting of the American Society of Aneshtesiologists
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 麻酔薬曝露及び手術侵襲による認知記憶障害メカニズムの解明2013

    • Author(s)
      内本一宏、宮崎智之、紙谷義孝、冨永陽介、松田洋子、後藤隆久.
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      ロイトン札幌他(北海道)
    • Related Report
      2012 Final Research Report
  • [Presentation] 麻酔薬暴露および手術侵襲による認知記憶障害のメカニズムの解明

    • Author(s)
      内本一宏、宮崎智之、紙谷義孝、富永陽介、松田洋子、後藤隆久
    • Organizer
      日本麻酔科学会第60回学術集会
    • Place of Presentation
      ロイトン札幌、北海道
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-22   Modified: 2019-07-29  

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