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The mechanisms of immunosuppression and organ dysfunctions following surgical stress and its modulation.

Research Project

Project/Area Number 22591755
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Anesthesiology/Resuscitation studies
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

KAWASAKI Takashi  産業医科大学, 医学部, 准教授 (60299633)

Co-Investigator(Kenkyū-buntansha) OKAMOTO Kohji  産業医科大学, 医学部, 非常勤医師 (50248572)
SATA Takeyoshi  産業医科大学, 医学部, 教授 (60128030)
Co-Investigator(Renkei-kenkyūsha) UEKI Masaya  産業医科大学, 医学部, 助教 (40534144)
HABE Kazutoshi  産業医科大学, 医学部, 助教 (50534145)
HAMADA Kohtaro  産業医科大学, 医学部, 助教 (70461580)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords外科的侵襲 / 臓器障害 / トロンボモジュリン / 合併症 / 外科侵襲 / サイトカイン / HMGB1
Research Abstract

The purposes of this study were to investigate the mechanisms of surgical stress induced immunosupPression and organ dysfunction and to develop the strategy of its regulation. After trauma-hemorrhage (T-H), plasma levels of TNF-α, IL-6, and HMGBl increased. Plasma AST and ALT concentrations also increased after T-H. Thrombomodulin (TM) treated improved plasma cytokines and HMGBl concentrations. Liver injury also improved. TM may be a beneficial treatment for surgical stressed patients.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (36 results)

All 2013 2012 2011 2010

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (18 results)

  • [Journal Article] Pentazocine Inhibits Norepinephrine Transporter Function by Reducing its Surface Expression in Bovine Adrenal Medullary Cells2013

    • Author(s)
      Obara G, Toyohira Y, Inagaki H, Takahashi K, Horishita T, Kawasaki T Ueno S, Tsutsui M, Sata T, Yanagihara N
    • Journal Title

      J Pharmacol Sci

      Volume: 121(2) Pages: 138-147

    • NAID

      10031156943

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dexmedetomidine Suppresses Proinflammatory Mediators Production in Human Whole Blood In Vitro2013

    • Author(s)
      Kawasaki T., Kawasaki C., Ueki M., Hamada K., Habe K., Sata T
    • Journal Title

      J Trauma Acute Care Surg

      Volume: 74(5) Pages: 1370-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Estrogen on Various Organs: Therapeutic Approach for Sepsis, Trauma, and Reperfusion Injury Part 1: Central Nervous System, Lung, and Heart (Review)2012

    • Author(s)
      Kawasaki T., Chaudry IH
    • Journal Title

      J Anesth

      Volume: 26(6) Pages: 883-891

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Estrogen on Various Organs: Therapeutic Approach for Sepsis, Trauma, and Reperfusion Injury Part 2: Liver, Intestine, Spleen, and Kidney(Review)2012

    • Author(s)
      Kawasaki T., Chaudry IH
    • Journal Title

      J Anesth

      Volume: 26(6) Pages: 892-899

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Impaired ability of burn patient neutrophils to stimulate β-defensin production by keratinocytes2012

    • Author(s)
      Kawasaki T.,Nakamura K.,Jeschke MG., Kogiso M.,Kabayashi M.,Herndon DN., Suzuki F
    • Journal Title

      Immunol Cell Biol

      Volume: 90(8) Issue: 8 Pages: 796-801

    • DOI

      10.1038/icb.2012.3

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Estrogen on Various Organs: Therapeutic Approach for Sepsis, Trauma, and Reperfusion Injury Part 1: Central Nervous System, Lung, and Heart2012

    • Author(s)
      Kawasaki T, Chaudry IH
    • Journal Title

      J Anesth

      Volume: 26 Issue: 6 Pages: 883-91

    • DOI

      10.1007/s00540-012-1425-3

    • NAID

      10031147423

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Effects of Estrogen on Various Organs: Therapeutic Approach for Sepsis, Trauma, and Reperfusion Injury Part 2: Liver, Intestine, Spleen, and Kidney2012

    • Author(s)
      Kawasaki T, Chaudry IH
    • Journal Title

      J Anesth

      Volume: 26 Issue: 6 Pages: 892-9

    • DOI

      10.1007/s00540-012-1426-2

    • NAID

      10031147424

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thrombosis from a prothrombin mutation conveying antithrombin resistance.2012

    • Author(s)
      Miyawaki Y, Suzuki A, Fujita J, Maki A, Okuyama E, Murata M, Takagi A, Murate T, Kunishima S, Sakai M, Okamoto K, Matsushita T, Naoe T, Saito H, Kojima T
    • Journal Title

      N Engl J Med.

      Volume: 366 Issue: 25 Pages: 2390-2396

    • DOI

      10.1056/nejmoa1201994

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of micafungin in empirical therapy of deep mycosis in surgically ill patients.2012

    • Author(s)
      Okamoto K, Katsuki T, Tamura T, Kanemitsu S, Minagawa N, Torigoe T, Shibao K, Higure A, Yamaguchi K
    • Journal Title

      J Infect Chemother

      Volume: 18 Issue: 5 Pages: 621-9

    • DOI

      10.1007/s10156-012-0381-z

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PPARgamma in the salutary effects of 17beta-estradiol on kupffer cell cytokine production following trauma-hemorrhage2011

    • Author(s)
      Suzuki T.,Kawasaki T.,Choudhry M. A., Chaudry I.H
    • Journal Title

      J Cell Physiol

      Volume: 226(1) Issue: 1 Pages: 205-211

    • DOI

      10.1002/jcp.22327

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lidocaine suppresses mouse Peyer' s patch cell functions and induces bacterial translocation2011

    • Author(s)
      Kawasaki T., Kawasaki C., Sata T., Chaudry I.H
    • Journal Title

      Surgery

      Volume: 149(1) Issue: 1 Pages: 106-113

    • DOI

      10.1016/j.surg.2010.03.024

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative Innate Immunity and Its Modulation(Review)2011

    • Author(s)
      Kawasaki T., Sata T
    • Journal Title

      J UOEH

      Volume: 33(2) Pages: 123-137

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perioperative Innate Immunity and Its Modulation2011

    • Author(s)
      Kawasaki T.
    • Journal Title

      J UOEH

      Volume: 33(Review) Pages: 123-137

    • NAID

      110008670937

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PPARgamma in the salutary effects of 17beta-estradiol on kupffer cell cytokine production following trauma-hemorrhage2011

    • Author(s)
      Suzuki T.
    • Journal Title

      J Cell Physiol

      Volume: 226 Pages: 205-211

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lidocaine suppresses mouse Peyer's patch T cell functions and induces bacterial translocation2011

    • Author(s)
      Kawasaki T.
    • Journal Title

      Surgery

      Volume: 149 Pages: 106-113

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PPARgamma in the salutary effects of 17beta-estradiol on kupffer cell cytokine production following trauma-hemorrhage.2011

    • Author(s)
      Suzuki T., Kawasaki T., Choudhry M.A., Chaudry I.H
    • Journal Title

      J Cell Physiol

      Volume: 226(1) Pages: 205-211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lidocaine suppresses mouse Peyer's patch T cell functions and induces bacterial translocation.2011

    • Author(s)
      Kawasaki T., Kawasaki C., Sata T., Chaudry I.H
    • Journal Title

      Surgery

      Volume: 149(1) Pages: 106-113

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of natural killer dendritic cell in host resistance against Pseudomonas aeruginosa infection after thermal injury in mice.2011

    • Author(s)
      Kawasaki T., Kabayashi M., Herndon D.N., Suzuki F.
    • Journal Title

      SHOCK

      Volume: 34(1) Pages: 83-89

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] EFFECTS OF THROMBOMODULIN TREATMENT IN EXPERIMENTAL HEAT STROKE2013

    • Author(s)
      T Kawasaki, C Kawasaki, K Okamoto, T Sata
    • Organizer
      Shock Society 36th Annual Conference on Shock, (6/3発表)
    • Place of Presentation
      San Diego, CA. U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Dexmedetomidine Suppresses plasma Pentraxin3 Level during Cardiac Surgery using Cardiopulmonary Bypass 2012 Annual Meeting2012

    • Author(s)
      Hamada K., Kawasaki T, Kawasaki C, Ueki M., Habe K., Sata T
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      Washington DC, U.S.A
    • Year and Date
      2012-10-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Neutrophils from Surgical Stressed Patients Suppress Beta-Defensin Production by Human Epidermal Keratinocyte2012

    • Author(s)
      T Kawasaki, C Kawasaki, K Okamoto, T Sata
    • Organizer
      7^<th> International Shock Congress, Shock Society 35th Annual Conference on Shock, (6/11発表)
    • Place of Presentation
      Miami Beach, FL. U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] The Anti-inflammatory Effect of Thrombomodulin on Brain in Experimental Heat Stroke2012

    • Author(s)
      C Kawasaki, T Kawasaki, K Okamoto, T Sata
    • Organizer
      7^<th> International Shock Congress, Shock Society 35th Annual Conference on Shoc, (6/10発表)
    • Place of Presentation
      Miami Beach, FL. U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Neutrophils from Surgical Stressed Patients Suppress Beta-Defensin Production by Human Epidermal Keratinocyte.2012

    • Author(s)
      Kawasaki T, Kawasaki C, Okamoto K, Sata T
    • Organizer
      7th International Shock Congress, Shock Society 35th Annual Conference on Shock
    • Place of Presentation
      Eden Roc Renaissance Resort & Spa, Miami Beach, FL, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] The Anti-inflammatory Effect of Thrombomodulin on Brain in Experimental Heat Stroke.2012

    • Author(s)
      Kawasaki C, Kawasaki T, Okamoto K, Sata T
    • Organizer
      7th International Shock Congress, Shock Society 35th Annual Conference on Shock
    • Place of Presentation
      Eden Roc Renaissance Resort & Spa, Miami Beach, FL, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dexmedetomidine Suppresses plasma Pentraxin3 Level during Cardiac Surgery using Cardiopulmonary Bypass.2012

    • Author(s)
      Hamada K, Kawasaki T, Kawasaki C, Ueki M, Habe K, Sata T
    • Organizer
      2012 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      Walter E. Washington Convention Center, Washington DC, U.S.A.
    • Related Report
      2012 Annual Research Report
  • [Presentation] Dexmedetomidine Suppresses plasma HMGB1 Level during Cardiac Surgery using Cardiopulmonary Bypass2011

    • Author(s)
      Ueki M.
    • Organizer
      2011 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      McCormick Place (Chicago, USA)
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Dexmedetomidine Suppresses plasma HMGBl Level during Cardiac Surgery using Cardiopulmonary Bypass 2011 Annual Meeting2011

    • Author(s)
      Ueki M, Kawasaki T, Kawasaki C, Hamada K, Sata T
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      Chicago, IL. U.S.A
    • Year and Date
      2011-10-13
    • Related Report
      2012 Final Research Report
  • [Presentation] THROMBOMODULIN IMPROVES THE LIVER INJURY IN EXPERIMENTAL HEAT STROKE2011

    • Author(s)
      Kawasaki T.
    • Organizer
      Shock Society 34th Annual Conference on Shock
    • Place of Presentation
      Marriot Norfolk Waterside (Norfolk, USA)
    • Year and Date
      2011-06-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 区域麻酔と予後:手術侵襲と免疫の面から2011

    • Author(s)
      川崎貴士
    • Organizer
      日本麻酔科学会第58回学術集会
    • Place of Presentation
      ポートピアホテル(神戸)(シンポジウム)
    • Year and Date
      2011-05-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] THROMBOMODULIN IMPROVES THE LIVER INJURY IN EXPERIMENTAL HEAT STROKE2011

    • Author(s)
      T Kawasaki, C Kawasaki, K Okamoto, T Sata
    • Organizer
      Shock Society 34th Annual Conference on Shock, (6/12発表)
    • Place of Presentation
      Norfolk, VA U.S.A
    • Related Report
      2012 Final Research Report
  • [Presentation] Elevation of HMGB1 Level during Cardiac Surgery Using Cardiopulmonary Bypass2010

    • Author(s)
      Ueki M., Kawasaki T., Sata T.
    • Organizer
      2010 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      San Diego, CA USA(The San Diego Convention Center)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dexmedetomidine Suppresses Proinflammatory Mediators Production in Human Whole Blood In Vitro2010

    • Author(s)
      Kawasaki T., Kawasaki C., Ueki M., Habe K., Sata T.
    • Organizer
      2010 Annual Meeting, American Society of Anesthesiologists
    • Place of Presentation
      San Diego, CA USA(The San Diego Convention Center)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Dexmedetonlidine Suppresses proinflanlnlatory Mediators Production in Human Whole Blood In Vitro 2010 Annual Meeting2010

    • Author(s)
      Kawasaki T, Kawasaki C, Ueki M, Habe K, Sata T
    • Organizer
      Anlerican Society of Anesthesiologists
    • Place of Presentation
      SanDiego, CA. U.S.A
    • Year and Date
      2010-10-12
    • Related Report
      2012 Final Research Report
  • [Presentation] Elevation of HMGBl Level during Cardiac Surgery using Cardiopulmonary Bypass 2010 Annual Meeting2010

    • Author(s)
      Ueki M, Kawasaki T, Sata T
    • Organizer
      American Society of Anesthesiologists
    • Place of Presentation
      SanDiego, CA. U.S.A
    • Year and Date
      2010-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] HMGB1 Contributes to the development of liver injury after heat stroke.2010

    • Author(s)
      Kawasaki T., Kawasaki C., Okamoto K., Sata T.
    • Organizer
      Shock Society 33rd Annual Conference on Shock
    • Place of Presentation
      Portland, OR USA(portland Marriou Downtown Waterfront)
    • Year and Date
      2010-06-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] HMGBl CONTRIBUTES TO THE DEVELOPMENT OF LIVER INJURY AFTER HEAT STROKE2010

    • Author(s)
      T Kawasaki, C Kawasaki, K Okamoto, T Sata
    • Organizer
      Shock Society 33rd Annual Conference on Shock, (6/13発表)
    • Place of Presentation
      Portland, OR U.S.A
    • Related Report
      2012 Final Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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