| Project/Area Number |
22591755
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Kohji 産業医科大学, 医学部, 非常勤医師 (50248572)
SATA Takeyoshi 産業医科大学, 医学部, 教授 (60128030)
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| Co-Investigator(Renkei-kenkyūsha) |
UEKI Masaya 産業医科大学, 医学部, 助教 (40534144)
HABE Kazutoshi 産業医科大学, 医学部, 助教 (50534145)
HAMADA Kohtaro 産業医科大学, 医学部, 助教 (70461580)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 外科的侵襲 / 臓器障害 / トロンボモジュリン / 合併症 / 外科侵襲 / サイトカイン / HMGB1 |
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| Research Abstract |
The purposes of this study were to investigate the mechanisms of surgical stress induced immunosupPression and organ dysfunction and to develop the strategy of its regulation. After trauma-hemorrhage (T-H), plasma levels of TNF-α, IL-6, and HMGBl increased. Plasma AST and ALT concentrations also increased after T-H. Thrombomodulin (TM) treated improved plasma cytokines and HMGBl concentrations. Liver injury also improved. TM may be a beneficial treatment for surgical stressed patients.
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