Laminin-like molecule is a potent therapeutic and diagnostic target for bladder cancer.
| Project/Area Number |
22591762
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SHUIN Taro 高知大学, 医学部, 教授 (70128601)
SHUO Takuya 東京大学, 医科学研究所, 特任研究員 (90399006)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 腫瘍マーカー / 膀胱がん / ラミニン / 診断 / 尿路がん / 尿 / 診断マーカー / 予後マーカー |
|---|
| Research Abstract |
In this study we demonstrated for the first time that monomeric laminin gamma2 chain was detected in urines obtained from the patients with early stage of bladder carcinomas by a sandwich ELISA assay using a specific antibody to human monomeric laminin gamma2 chain(To be submitted). Furthermore urinary monomeric laminin gamma2 was expressed not only in invasive but also in surface carcinomas. The diagnostic value of monomeric laminin gamma2 was higher than that of other marker proteins (MTA, NMP-22) of bladder carcinoma urine. These results strongly suggest that urinary monomeric laminin gamma2 has the possibility to be a potent novel tumor marker for bladder carcinoma.
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] MT1-MMP plays a critical role in henatopoiesis by regulating HIF-mediated chemo-/cytokine gene transcription within niche cells.2012
Author(s)
Chiemi Nishida, Kaori Kusubata, Yoshihiko Tashiro, Ismael Gritli, Aki Sato, Makiko Ohki-Koizumi, Yohei Morita, Makoto Nagano, Takeharu Sakamoto, Naohiko Koshikawa, Takahiro Kuchimaru, Shinae Kizaka-Kondoh, Motoharu Seiki, Hiromitsu Nakauchi, Beate Heissig, and Koichi Hattori.
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Journal Title
Blood
Volume: 119
Issue: 23
Pages: 5404-5416
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment and validation of computational model for MT1-MMP dependent ECM degradation and intervention strategies2012
Author(s)
Hoshino, D., Koshikawa, N., Suzuki, T., Quaranta, V., Weaver, A.M., (Seiki, M.), Ichikawa, K.
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Journal Title
PLoS Comp.Biol.
Volume: 8
Issue: 4
Pages: e1002479-e1002479
DOI
Related Report
Peer Reviewed
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[Journal Article] ZF21 protein, a regulator of the disassembly of focal adhesions and cancer metastasis, contains a novel noncanonical pleckstrin homology domain2011
Author(s)
Nagano M, Hoshino D, Koshiba S, Shuo T Koshikawa N, Tomizawa T, Hayashi F, Tochio N, Harada T, Akizawa T Watanabe S, Handa N, Shirouzu M, Kigawa T, Yokoyama S, Seiki M
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Journal Title
J Biol Chem.
Volume: 286(36)
Issue: 36
Pages: 31598-609
DOI
Related Report
Peer Reviewed
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