Research for a mechanism of urologic cancer metastasis through a GAP signaling pathway
| Project/Area Number |
22591766
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Osamu 京都大学, 大学院・医学研究科, 教授 (90260611)
YOSHIMURA Koji 京都大学, 大学院・医学研究科, 准教授 (40397542)
SHIMIZU Yosuke 京都大学, 大学院・医学研究科, 助教 (00542094)
西山 博之 京都大学, 医学研究科, 准教授 (20324642)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIUCHI Hisanori 東北大学, 加齢医学研究所, 教授 (90291426)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 膀胱癌 / 前立腺癌 / Ral / GAP(GTPase-activating protein) / GAP / 転移 |
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| Research Abstract |
Ral was highly activated in invasive bladder cancer cells due to reduced expression of RalGAPa2. Exogenous expression of RalGAPa2 in bladder cancer cells with invasive phenotype resulted in attenuated cell migration in vitro and lung metastasis in vivo. Genetic ablation of Ralgapa2 promoted tumor invasion in a chemically-induced murine bladder cancer model. Immunohistochemical analysis of human bladder cancer specimens revealed that lower expression of RalGAPa2 was associated with advanced clinical stage and poor survival of patients. Collectively, these results are highly indicative that attenuated expression of RalGAPa2 leads to disease progression of bladder cancer through enhancement of Ral activity.
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Report
(4 results)
Research Products
(15 results)
