| Project/Area Number |
22591779
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
NAKASHIMA Jun 東京医科大学, 医学部, 教授 (10167546)
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| Co-Investigator(Kenkyū-buntansha) |
TACHIBANA Masaaki 東京医科大学, 医学部, 教授 (70129526)
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| Co-Investigator(Renkei-kenkyūsha) |
HORIGUCHI Yutaka 東京医科大学, 医学部, 准教授 (60229234)
OHNO Yoshio 東京医科大学, 医学部, 准教授 (40266482)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍学 / 前立腺癌 / NFκB / 内分泌治療 / 放射線治療 / NF-κB / NFkappaB / cell cycle / docetaxel |
|---|
| Research Abstract |
This study was undertaken to elucidate the pathophysiological role of NFκB－IL6 pathway and antitumor effects of NF κB inhibitors including dihydroxymethylepoxyquinomicin (DHMEQ) in prostate cancer. DHMEQ showed significant cytotoxic effects on prostate cancer cells in dose dependent and time dependent manners, produced a significant increase in G2/M arrest in the cell cycle and enhanced the cytotoxic effects of docetaxel on prostatecancer cells. DHMEQ significantly enhanced cytotoxic effects of radiation on prostate cancer, presumably through inhibiting the increased NFκB activity induced by radiation and enhancing the proportion of G2/M arrest in the cells in combination with radiation. Inhibition of NFκB activity may become a new therapeutic modality for treating prostate cancer.
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