| Project/Area Number |
22591793
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Urology
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
SEKI Narihito 九州大学, 医学研究院, 特別研究員 (90294941)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
NAKAYAMA Shinsuke 名古屋大学, 医学部, 准教授 (30192230)
KAJIOKAI Shunichi 九州大学, 医学研究院, 特任准教授 (90274472)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | 間質細胞 / 排尿筋 / 膀胱出口閉塞 / カルシウム電流 / 過活動膀胱 / 膀胱排尿筋 / 神経伝達物質 / 間質性細胞 / ギャップジャンクン |
|---|
| Research Abstract |
It is well known that c-kit positive interstitial cells act as pacemaker cells of peristaltic movement. However, the studies of interstitial cells of urinary bladder have not been sufficiently accumulated. Our present study revealed that c-kit positive interstitial cells were solely distributed between muscle bundles in human urinary bladder different from those in gastrointestinal tract. In guinea-pig urinary bladder, bladder outlet obstruction potentiated the amplitude of the spontaneous electrical activities and the oscillatory activities induced by the stimulation of muscarinic and purinergic receptors using micro multiple electrode arrays.Tyrosine kinase inhibitor (sorafenib), gap junction inhibitor (mefloquine) and Rho kinase inhibitor (fasudil) predominantly inhibited the oscillatory contraction induced by muscarinic contraction in human detrusor. These results suggest the novel treatment strategy for lower urinary tract syndrome such as overactive bladder.
|
