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Association between single nucleotide polymorphism of beta2-Adrenergic receptor gene and pelvic floor muscle function in POP and/or SUI patients

Research Project

Project/Area Number 22591795
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionFukushima Medical University

Principal Investigator

SHISHIDO Keiichi  福島県立医科大学, 医学部, 博士研究員 (30285035)

Co-Investigator(Kenkyū-buntansha) ISHIBASHI Kei  福島県立医科大学, 医学部, 講師 (90347211)
高橋 則雄  福島県立医科大学, 医学部, 助教 (50622312)
野宮 正範  福島県立医科大学, 医学部, 助教 (00398348)
Co-Investigator(Renkei-kenkyūsha) NOMIYA Masanori  福島県立医科大学, 医学部, 助教 (00398348)
TAKAHASHI Norio  福島県立医科大学, 医学部, 助教 (50622312)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsss2 受容体 / 女性骨盤底 / 遺伝子多型 / 骨盤底筋 / β2受容体 / 骨盤臓器脱
Research Abstract

Patients with pelvic organ prolapse (POP) and/or stress urinaryincontinence have lower pelvic floor muscle (PFM) function. We hypothesized that single nucleotide polymorphism of beta 2-Adrenergic receptor gene could be associated with pelvic floor muscle function. We have developed our original system which can record the intra-vaginal pressure by touch sensor array and PFM movement by evaluation using an intravaginal probe. We have also established the methods which can detect single nucleotide polymorphism of beta 2-Adrenergic receptor gene by TaqMan methods using real time PCR. Further studies with number of POP and/or SUI cases are required to confirm ourhypothesis.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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