Analysis of the factors on male infertility and habitual abortion & their Applications to clinical medicine

• Project/Area Number: 22591811
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Asahikawa Medical College
• Principal Investigator: MIYAMOTO Toshinobu 旭川医科大学, 医学部, 講師 (70360998)
• Co-Investigator(Kenkyū-buntansha): SENGOKU Kazuo 旭川医科大学, 医学部, 教授 (30163124)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 生殖医学 / azoospermia / SCOS / MA / SNP / 無精子症 / 減数分裂 / mutation / 不妊症 / SEPTIN12

Research Abstract

We identified the human HORMAD1 gene causing azoospermia by meiotic arrest. In Addition, We also identified the human LRWD1 gene causing azoospermia by SCOS and we demonstrated that the human SEPTIN12 is critical in azoospermia by MA and SCOS.

Research Products

• [Journal Article] Single-nucleotide polymorphisms in the LRWD1 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome (2013)
  • Author(s): Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K
  • Journal Title: Andrologia Volume: 46 Issue: 3 Pages: 273-276
  • DOI: 10.1111/and.12077
• [Journal Article] Clinicopathologic risk factors for recurrence of ovarian endometrioma following laparoscopic cystectomy (2013)
  • Author(s): Sengoku K, Miyamoto T, Horikawa M, Katayama H, Nishiwaki K, Kato Y, Kawanishi Y, Saijo Y.
  • Journal Title: Acta Obstet Gynecol Scand Volume: 92(3) Issue: 3 Pages: 278-84
  • DOI: 10.1111/aogs.12051
  • Peer Reviewed
• [Journal Article] Pathogenic mutations in two families with congenital cataract identified with whole-exome sequencing (2013)
  • Author(s): Kondo Y, Saitsu H, Miyamoto T, Lee BJ, Nishiyama K, Nakashima M, Tsurusaki Y, Doi H, Miyake N, Kim JH, Yu YS, Matsumoto N
  • Journal Title: Mol Vis Volume: 19 Pages: 384-9
• [Journal Article] Study of the vulvar skin in healthy Japanese women: components of the stratum corneum and microbes (2012)
  • Author(s): Miyamoto T, Akiba S, Sato N, Fujimura T, Takagi Y, Kitahara T, Takema Y, Iizuka H, Sengoku K.
  • Journal Title: Int J Dermatol Volume: 52 Issue: 12 Pages: 1500-1505
  • DOI: 10.1111/j.1365-4632.2012.05582.x
  • Peer Reviewed
• [Journal Article] Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients (2012)
  • Author(s): Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K.
  • Journal Title: Asian J Androl Volume: 14(4) Pages: 580-3
  • NAID: 120006580771
• [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men (2012)
  • Author(s): Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Horikawa M, Saijo Y, Sengoku K.
  • Journal Title: J Assist Reprod Genet Volume: 29(1) Pages: 47-51
• [Journal Article] Male infertility and its causes in human (2012)
  • Author(s): Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Namiki M, Sengoku K.
  • Journal Title: Adv Urol 2012 Volume: 2012 Pages: 384520-384520
  • DOI: 10.1155/2012/384520
  • Peer Reviewed
• [Journal Article] Single-nucleotide polymorphisms in the SEPTIN12 gene may be a genetic risk factor for Japanese patients with Sertoli cell-only syndrome (2012)
  • Author(s): Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K.
  • Journal Title: J Androl Volume: 53(3) Pages: 483-7
• [Journal Article] A family of oculofaciocardiodental syndrome (OFCD) with a novel BCOR mutation and genomic rearrangements involving NHS (2012)
  • Author(s): Kondo Y, Saitsu H, Miyamoto T, Nishiyama K, Tsurusaki Y, Doi H, Miyake N, Ryoo NK, Kim JH, Yu YS, Matsumoto N
  • Journal Title: J Hum Genet Volume: 57(3) Pages: 197-201
  • NAID: 10030712110
• [Journal Article] Single-nucleotide polymorphisms in HORMAD1 may be a risk factor for azoospermia caused by meiotic arrest in Japanese patients (2012)
  • Author(s): Miyamoto T, et al.
  • Journal Title: Asian J Androl Volume: 14 Issue: 4 Pages: 580-583
  • DOI: 10.1038/aja.2011.180
  • NAID: 120006580771
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men. (2012)
  • Author(s): Miyamoto T
  • Journal Title: J Assist Reprod Genet. Volume: 29 Issue: 1 Pages: 47-51
  • DOI: 10.1007/s10815-011-9679-5
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphisms in the SEPTIN12 gene may be associated with azoospermia by meiotic arrest in Japanese men (2012)
  • Author(s): Miyamoto T, et al.
  • Journal Title: J Assist Reprod Genet Volume: 29 Pages: 47-51
  • Peer Reviewed
• [Journal Article] Male infertility and its causes in human (2012)
  • Author(s): Miyamoto T, et al.
  • Journal Title: Adv Urol Volume: 2012 Pages: 384520-384520
  • Peer Reviewed
• [Journal Article] Single-Nucleotide Polymorphisms in the SEPTIN12 Gene May Be a Genetic Risk Factor for Japanese Patients with Sertoli Cell-Only Syndrome (2011)
  • Author(s): Miyakawa H, Miyamoto T, Koh E, Tsujimura A, Miyagawa Y, Saijo Y, Namiki M, Sengoku K
  • Journal Title: J Androl Volume: (Epub ahead of print) Issue: 3 Pages: 483-487
  • DOI: 10.2164/jandrol.110.012146
  • Peer Reviewed
• [Journal Article] Single-Nucleotide Polymorphisms in the SEPTIN12 Gene May Be a Grenetic Risk Factor for Japanese Patients with Sertoli Cell-Only Syndrome (2011)
  • Author(s): Miyakawa H, Miyamoto T, et al.
  • Journal Title: J Androl
  • Peer Reviewed
• [Journal Article] Single nucleotide polymorphism in the UBR2 gene may be a genetic risk factor for Japanese patients with azoospermia by meiotic arrest (2011)
  • Author(s): Miyamoto T, et al.
  • Journal Title: J Assist Reprod Genet Volume: 28 Pages: 743-746
  • Peer Reviewed
• [Journal Article] Current concepts of human azoospermia and its causes. (2010)
  • Author(s): Miyamoto T, Tsujimura A, Miyagawa Y, Koh E, Sato H, et al.
  • Journal Title: Reprod Med Biol Volume: 9 Pages: 121-127
  • NAID: 10027050484
  • Peer Reviewed
• [Journal Article] 不妊と遺伝因子 (2010)
  • Author(s): 宮本敏伸、佐藤恒、千石一雄
  • Journal Title: 産婦人科の実際 Volume: 59 Pages: 1959-1967
• [Journal Article] 不妊への対応PCOSにおける排卵誘発法と問題点】経口薬 (2010)
  • Author(s): 千石一雄、佐藤恒、宮本敏伸
  • Journal Title: 産婦人科の実際 Volume: 64 Pages: 157-161
• [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析 (2012)
  • Author(s): 宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
  • Organizer: 日本生殖医学会
• [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析 (2012)
  • Author(s): 宮本 敏伸,宮川 博栄,千石 一雄
  • Organizer: 日本産婦人科学会
• [Presentation] ヒト無精子症におけるヒトSEPTIN12遺伝子の解析 (2012)
  • Author(s): 宮本敏伸
  • Organizer: 日本産婦人科学会総会
  • Place of Presentation: 横浜市
• [Presentation] ヒト無精子症におけるヒトHOMAD1遺伝子の解析 (2012)
  • Author(s): 宮本敏伸
  • Organizer: 日本生殖医学会総会
  • Place of Presentation: 長崎市
• [Presentation] ヒト無精子症原因候補遺伝子であるSEPTIN12遺伝子の解析 (2011)
  • Author(s): 宮本敏伸
  • Organizer: 第56回日本生殖医学会学術講演会・総会
  • Place of Presentation: 横浜市
  • Year and Date: 2011-12-08
• [Presentation] ヒト精子形成過程におけるヒト HOMAD1 遺伝子の解析 (2011)
  • Author(s): 宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
  • Organizer: 日本生殖医学会
• [Presentation] ヒト精子形成過程におけるヒト HOMAD1 遺伝子の解析 (2011)
  • Author(s): 宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
  • Organizer: 日本産婦人科学会
• [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析 (2011)
  • Author(s): 宮本 敏伸,宮川 博栄,岡部 公香,千石 一雄
  • Organizer: 日本生殖医学会
• [Presentation] ヒト精子形成過程におけるヒト SEPTIN12 遺伝子の解析 (2011)
  • Author(s): 宮本 敏伸,宮川 博栄,千石 一雄
  • Organizer: 日本産婦人科学会
• [Presentation] 当教室において同定されたヒト無精子症に関わる遺伝子群 (2010)
  • Author(s): 宮本敏伸
  • Organizer: 第62回日本産婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム(東京)
  • Year and Date: 2010-04-24