| Project/Area Number |
22591815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
|
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| Research Institution | Yamagata University |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IGARASHI Hideki 山形大学, 医学部, 助教 (80333970)
AMITA Mitsuyoshi 山形大学, 医学部, 助教 (30420061)
KURACHI Hirohisa 山形大学, 医学部, 教授 (40153366)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 卵の加齢 / メタボロミクス / オートファジー / 細胞内カルシウム制御機構 / ATP / 加齢マウス / 細胞内カルシウム / カルシウムオシレーション / メタボローム / アポトーシス / ミトコンドリア / 酸化ストレス |
|---|
| Research Abstract |
The age-associated decline in female fertility is largely attributableto the decrease in oocyte quality due to ovarian aging. However, the precise mechanism ofoocyte aging due to ovarian aging remains unknown. In the present study, we examined themolecular mechanisms of age-related decline in oocyte quality by metabolomics and analyzing autophagy.
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