Study for elucidation of gene-environment interaction in the manifestation of pregnancy-induced hypertension
| Project/Area Number |
22591842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | National Institute of Radiological Sciences |
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Principal Investigator |
KOBASHI Gen 独立行政法人放射線医学総合研究所, 企画部研究倫理企画支援室, 室長 (60270782)
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| Co-Investigator(Kenkyū-buntansha) |
HATA Akira 千葉大学, 大学院医学研究院, 教授 (00244541)
MINAKAMI Hisanori 北海道大学, 大学院医学研究院, 教授 (40102256)
YAMADA Hideto 神戸大学, 大学院医学研究院, 教授 (40220397)
SUGIMORI Hiroki 大東文化大学, スポーツ健康科学部, 教授 (20276554)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 産科学 / 妊娠高血圧症候群 / 遺伝子多型 / 疫学 / ストレス / 相互作用 / 周産期 / 妊娠中のストレス / フォーカスグループ面接 |
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| Research Abstract |
Performing genotyping of some kings of candidate genetic variants for PIH, G-308A polymorphism of TNF-A was associated with PIH. Propensity score analysis was needed to carry out epidemiological study of PIH in the future. A retrospective analysis using the registry system suggested that more intensified monitoring of nulliparous women and teenaged girls besides hypertension is needed in order to prevent eclampsia.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population2012
Author(s)
Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R
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Journal Title
J Epidemiol
Volume: 22
Pages: 91-102
NAID
Related Report
Peer Reviewed
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[Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population2012
Author(s)
Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R
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Journal Title
J Epidemiol
Volume: 22
Pages: 91-102
NAID
Related Report
Peer Reviewed
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[Journal Article] Psychological stress in systemic lupus erythematosus in a Japanese population: Finding from KYSS study
Author(s)
Takahashi H, Washio M,, Kiyohara C, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Yamamoto M, Horiuchi T, the Kyushu Sapporo SLE (KYSS) Study Group
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Journal Title
Modern Rheumatology Modern Rheumatol
Volume: (in press)
Related Report
Peer Reviewed
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