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Study for elucidation of gene-environment interaction in the manifestation of pregnancy-induced hypertension

Research Project

Project/Area Number 22591842
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionNational Institute of Radiological Sciences

Principal Investigator

KOBASHI Gen  独立行政法人放射線医学総合研究所, 企画部研究倫理企画支援室, 室長 (60270782)

Co-Investigator(Kenkyū-buntansha) HATA Akira  千葉大学, 大学院医学研究院, 教授 (00244541)
MINAKAMI Hisanori  北海道大学, 大学院医学研究院, 教授 (40102256)
YAMADA Hideto  神戸大学, 大学院医学研究院, 教授 (40220397)
SUGIMORI Hiroki  大東文化大学, スポーツ健康科学部, 教授 (20276554)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords産科学 / 妊娠高血圧症候群 / 遺伝子多型 / 疫学 / ストレス / 相互作用 / 周産期 / 妊娠中のストレス / フォーカスグループ面接
Research Abstract

Performing genotyping of some kings of candidate genetic variants for PIH, G-308A polymorphism of TNF-A was associated with PIH. Propensity score analysis was needed to carry out epidemiological study of PIH in the future. A retrospective analysis using the registry system suggested that more intensified monitoring of nulliparous women and teenaged girls besides hypertension is needed in order to prevent eclampsia.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2013 2012 2011 2010 Other

All Journal Article (19 results) (of which Peer Reviewed: 14 results) Presentation (2 results) (of which Invited: 1 results) Book (11 results)

  • [Journal Article] Association of antithrombin activity with plasma aldosterone concentration and plasma Renin activity in pregnant women2013

    • Author(s)
      Yamada T, Koyama T, Furuta I, Morikawa M, Yamada T, Minakami H
    • Journal Title

      Hypertens Pregnancy

      Volume: 32 Pages: 96-113

    • NAID

      120005372318

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies2013

    • Author(s)
      Yamada T, Morikawa M, Yamada T, Kishi R, Sengoku K, Endo T, Saito T, Cho K, Minakami H
    • Journal Title

      Arch Gynecol Obstet

      Volume: 287 Pages: 9-13

    • NAID

      120005358926

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 橋渡しと連携のための疫学(その1)疫学の定義と方法について2013

    • Author(s)
      小橋 元
    • Journal Title

      放射線科学

      Volume: 56 Pages: 35-38

    • NAID

      40019760876

    • Related Report
      2012 Final Research Report
  • [Journal Article] Association of antithrombin activity with plasma aldosterone concentration and plasma Renin activity in pregnant women.2013

    • Author(s)
      Yamada T
    • Journal Title

      Hypertens Pregnancy

      Volume: 32 Pages: 96-103

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] First-trimester serum folate levels and subsequent risk of abortion and preterm birth among Japanese women with singleton pregnancies.2013

    • Author(s)
      Yamada T
    • Journal Title

      Arch Gynecol Obstet

      Volume: 287 Pages: 9-14

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors of eclampsia other than hypertension: pregnancy-induced antithrombin deficiency and extraordinary weight gain2012

    • Author(s)
      Yamada T, Kuwata T, Matsuda H, Deguchi K, Morikawa M, Yamada T, Furuya K, Matsubara S, Minakami H
    • Journal Title

      Hypertens Pregnancy

      Volume: 31 Pages: 268-277

    • NAID

      120005326759

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and tobacco smoking on infant birth weight in a Japanese population2012

    • Author(s)
      Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R
    • Journal Title

      J Epidemiol

      Volume: 22 Pages: 91-102

    • NAID

      10030213303

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors for eclampsia in Japan between 2005 and 20092012

    • Author(s)
      Morikawa M, Cho K, Yamada T, Yamada T, Sato S, Minakami H
    • Journal Title

      Int J Gynaecol Obstet

      Volume: 117 Pages: 66-68

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Risk factors of eclampsia other than hypertension: pregnancy-induced antithrombin deficiency and extraordinary weight gain.2012

    • Author(s)
      Yamada T
    • Journal Title

      Hypertens Pregnancy

      Volume: 31 Pages: 268-277

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 放射線と健康 ~より良い公衆衛生活動のために~.2012

    • Author(s)
      小橋 元
    • Journal Title

      社会医学研究

      Volume: 28 Pages: 1-8

    • NAID

      10031136140

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of maternal 5,10-methylenetetrahydrofolate reductase C677T and A1298C Polymorphisms and tobacco smoking on infant birth weight in a Japanese population2012

    • Author(s)
      Yila TA, Sasaki S, Miyashita C, Braimoh TS, Kashino I, Kobayashi S, Okada E, Baba T, Yoshioka E, Minakami H, Endo T, Sengoku K, Kishi R
    • Journal Title

      J Epidemiol

      Volume: 22 Pages: 91-102

    • NAID

      10030213303

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-β2 glycoprotein-I antibody increases the risk of pregnancy-induced hypertension: a case control study2010

    • Author(s)
      Yamada H, Atsumi T, Amengual O, Koike T, Furuta I, Ohta K, Kobashi G
    • Journal Title

      J Reprod Immunol

      Volume: 84 Pages: 95-99

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 社会医学実習での疫学調査を行う際の倫理に関する教育の実態2010

    • Author(s)
      鷲尾昌一、尾島俊之、玉腰暁子、酒井美知、武藤香織、小橋 元、石川鎮清、大神英一、太田薫里、佐藤恵子、鈴木美香、杉森裕樹、内藤真理子、中山健夫、丸山英二、山縣然太朗
    • Journal Title

      臨床と研究

      Volume: 87 Pages: 1473-1481

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体は産科異常,特に妊娠高血圧症候群と関連する2010

    • Author(s)
      山田秀人,小橋 元,渥美達也
    • Journal Title

      産婦人科の実際

      Volume: 59 Pages: 789-794

    • NAID

      40017137508

    • Related Report
      2012 Final Research Report
  • [Journal Article] 妊娠高血圧症候群と遺伝因子2010

    • Author(s)
      小橋 元,水上尚典,山田秀人
    • Journal Title

      産婦人科の実際

      Volume: 59 Pages: 2001-2007

    • Related Report
      2012 Final Research Report 2010 Annual Research Report
  • [Journal Article] 臨床研究管理支援体制の整備2010

    • Author(s)
      福島芳子、末竹弘樹、石田有香、伊藤浩、石川顕一、上田順市、小橋 元、吉本泰彦、佐藤眞一郎
    • Journal Title

      放射線科学

      Volume: 53 Pages: 51-53

    • Related Report
      2012 Final Research Report
  • [Journal Article] Anti-β2 glycoprotein-I antibody increases the risk of pregnancy-induced hypertension : a case control study.2010

    • Author(s)
      Yamada H, Atsumi T, Amengual O, Koike T, Furuta I, Ohta K, Kobashi G
    • Journal Title

      J.Reprod.Immunol.

      Volume: 84 Pages: 95-99

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 抗リン脂質抗体は産科異常, 特に妊娠高血圧症候群と関連する2010

    • Author(s)
      山田秀人, 小橋元, 渥美達也
    • Journal Title

      産婦人科の実際

      Volume: 59 Pages: 789-794

    • NAID

      40017137508

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Psychological stress in systemic lupus erythematosus in a Japanese population: Finding from KYSS study

    • Author(s)
      Takahashi H, Washio M,, Kiyohara C, Tada Y, Asami T, Ide S, Atsumi T, Kobashi G, Yamamoto M, Horiuchi T, the Kyushu Sapporo SLE (KYSS) Study Group
    • Journal Title

      Modern Rheumatology Modern Rheumatol

      Volume: (in press)

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 公衆衛生学的(疫学的)見地からみた放射線(電離放射線)とその健康影響2012

    • Author(s)
      小橋 元
    • Organizer
      日本臨床環境医学会
    • Place of Presentation
      新潟県南魚沼市
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 放射線と遺伝 ~ 疫学・公衆衛生学の立場から2011

    • Author(s)
      小橋 元
    • Organizer
      日本人類遺伝学会第56回大会 (シンポジウム「放射線被曝と遺伝学」
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-12
    • Related Report
      2012 Final Research Report
  • [Book] 第7章 環境と健康、1.生態系と人間、5)電離放射線、6)非電離放射線、第8章 産業保健(労働衛生)、9.職業性疾病とその予防対策、5)電離放射線障害とその防止対策.これからの公衆衛生学2013

    • Author(s)
      小橋 元
    • Publisher
      田中平三編.南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 第5章 危機管理計画、第6章 リスク評価とリスク管理.最悪に備えよ―医薬品および他の医療関連危機を予測し回避または管理する2013

    • Author(s)
      小橋 元
    • Publisher
      ブルース・ハグマン、ジェリー・ラバディック著.杉森裕樹、大神英一、山本美智子、折井孝男、中山健夫監訳.じほう
    • Related Report
      2012 Final Research Report
  • [Book] Subnote 保健医療論・公衆衛生学 20132012

    • Author(s)
      小橋 元、岡本悦司他監修
    • Publisher
      メディックメディア編・発行
    • Related Report
      2012 Final Research Report
  • [Book] Subnote 保健医療論・公衆衛生学 2013 (pp204-229「母子保健」担当2012

    • Author(s)
      小橋 元
    • Total Pages
      469
    • Publisher
      メディックメディア
    • Related Report
      2012 Annual Research Report
  • [Book] Subnote保健医療論・公衆衛生学2011

    • Author(s)
      岡本悦司、兼板佳孝、小橋元、坂田清美、佐藤敏彦、吉池信男
    • Total Pages
      469
    • Publisher
      メディックメディア
    • Related Report
      2011 Annual Research Report
  • [Book] 頻度の測定、頻度の比較.はじめて学ぶやさしい疫学 ―疫学への招待―(第2版)2010

    • Author(s)
      小橋 元 田中平三、能勢隆之編.
    • Publisher
      南江堂
    • Related Report
      2012 Final Research Report
  • [Book] 疫学.NEXT 公衆衛生学(第3版)2010

    • Author(s)
      小橋 元 村松 宰,中山健夫編.
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2012 Final Research Report
  • [Book] 疫学で用いられる指標.はじめて学ぶやさしい疫学-疫学への招待-(改訂第2版)2010

    • Author(s)
      小橋元
    • Total Pages
      11
    • Publisher
      南江堂
    • Related Report
      2010 Annual Research Report
  • [Book] 労働衛生学校保健.図説 国民衛生の動向2010120112010

    • Author(s)
      小橋元
    • Total Pages
      8
    • Publisher
      厚生統計協会
    • Related Report
      2010 Annual Research Report
  • [Book] 母子保健.Sub Note保健医療論・公衆衛生学2010

    • Author(s)
      小橋元, 他
    • Total Pages
      28
    • Publisher
      国試対策問題編集委員会
    • Related Report
      2010 Annual Research Report
  • [Book] Confounding of Genetic and Environmental factors in Pregnancy-Induced Hypertension

    • Author(s)
      Kobashi G
    • Publisher
      Nova Science Publishers, Inc.
    • Related Report
      2012 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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