The effect of estrogen for carbohydrate metabolism in pancreatic beta cells
Project/Area Number |
22591853
|
Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Obstetrics and gynecology
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Research Institution | Shinshu University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KOMATSU Mitsuhisa 信州大学, 医学部, 教授 (90221978)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | エストロゲン / 膵β細胞 / 転写調節因子 / インスリンプロモーター / 膣β組胞 / 転写調節子 |
Research Abstract |
We have demonstrated the treatment of HIT-T15 insulinoma cellswith E2 led to the decreased insulin mRNA levels. Transient transfection assays of HIT-T15 cells revealed that ERα repressed transcriptional activity of rat insulin II promoter bothin a ligand-dependent and -independent manner. The repression was not mediated by an ERE-like sequence or AP-1 site in the promoter. Instead, transcriptional factor PDX-1 and BETA2 appear to be involved.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] Humoral hypercalcemia associated with gastric carcinoma secreting parathyroid hormone: a case report and review of the literature2013
Author(s)
Nakajima K, Tamai M, Okaniwa S, Nakamura Y, Kobayashi M, Niwa T, Horigome N, Ito N, Suzuki S, Nishio S, Komatsu M.
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Journal Title
Endocrine Journal
Volume: 60
Issue: 5
Pages: 557-562
DOI
NAID
ISSN
0918-8959, 1348-4540
Related Report
Peer Reviewed
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[Journal Article] Fasting induces CART down-regulation in the zebrafish nervous system in a cannabinoid receptor 1-dependent manner.2012
Author(s)
Nishio S, Gibert Y, Berekelya L, Bernard L, Brunet F, Guillot E, Le Bail JC, Sánchez JA, Galzin AM, Triqueneaux G, Laudet V.
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Journal Title
Mol Endocrinol.
Volume: 26(8)
Issue: 8
Pages: 1316-1326
DOI
Related Report
Peer Reviewed
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