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endometrial cancer therapy using epigenetically regulated small RNA

Research Project

Project/Area Number 22591866
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

BANNO Kouji  慶應義塾大学, 医学部, 講師 (70265875)

Co-Investigator(Kenkyū-buntansha) YANOKURA Megumi  慶應義塾大学, 医学部, 特任助教 (20433732)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords婦人科腫瘍学 / 子宮体癌 / CHFR / miR-34b / タキサン製剤 / パクリタキセル / miRNA / メチル化 / エピジェネティック / siRNA
Research Abstract

It is revealed that CHFR gene is epigenetically regulated in endometrial cancer. CHFR gene methylation is correlated with response to Taxane. Micro RNA is also regulated by DNA methylation in endometrial cancer. miR-34b is important for the oncogenesis of

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (16 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (8 results)

  • [Journal Article] MicroRNAs in endometrial cancer.2013

    • Author(s)
      Banno K, Yanokura M, Kisu I, Yamagami W, Susumu N, Aoki D
    • Journal Title

      International journal of clinical oncology

      Volume: 18 Issue: 2 Pages: 186-192

    • DOI

      10.1007/s10147-013-0526-9

    • NAID

      10031176254

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics.2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: 2012 Pages: 738274-738274

    • DOI

      10.1155/2012/738274

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice.2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
    • Journal Title

      Epigenomics

      Volume: 4 Issue: 2 Pages: 147-162

    • DOI

      10.2217/epi.12.13

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetics and genetics in endometrial cancer : new carcinogenic mechanisms and relationship with clinical practice2012

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
    • Journal Title

      Epigenomics

      Volume: 4 Pages: 147-162

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Flexible hysteroscopy with narrow band imaging (NBI) for endoscopic diagnosis of malignant endometrial lesions.2011

    • Author(s)
      木須伊織
    • Journal Title

      International Journal of Oncology

      Volume: 38(3) Pages: 613-618

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)2010

    • Author(s)
      Yanokura M, Banno K, Kobayashi Y, Kisu I, Ueki A, Ono A, Masuda K, Nomura H, Hirasawa A, Susumu N, Aoki D
    • Journal Title

      Oncol Lett

      Volume: 1(6) Pages: 935-940

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22870090

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA and microRNA by Epigenetics

    • Author(s)
      Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
    • Journal Title

      Biochemistry Research International

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomarkers in Endometrial Cancer : Possible clinical applications

    • Author(s)
      Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
    • Journal Title

      Oncology Letters

      Volume: (Review)(印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Aberrant epigenetic DNA hypermethylation in liquid-based endometrial cytology samples: evaluation and potential use in diagnosis.2012

    • Author(s)
      阪埜 浩司
    • Organizer
      37th Europian congress of Cytology
    • Place of Presentation
      ドブロブニク(クロアチア)
    • Year and Date
      2012-10-01
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌に対する miR-34b とパクリタキセル併用による抗腫瘍効果の検討2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌においてエピジェネティックに制御される miR-34b の同定とその癌抑制効果2012

    • Author(s)
      矢野倉 恵
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 専攻医教育プログラム 卵巣がん2012

    • Author(s)
      阪埜 浩司
    • Organizer
      第64回日本産科婦人科学会学術講演会
    • Place of Presentation
      神戸
    • Year and Date
      2012-04-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 子宮体癌においてエピジェネティックに制御されるmiR-34bの同定とその癌抑制効果2012

    • Author(s)
      矢野倉恵
    • Organizer
      日本産科婦人科学会
    • Place of Presentation
      神戸国際展示場(神戸)(発表確定)
    • Year and Date
      2012-04-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] A microRNA that is epigeneticcaly regulated and functions as a tumor suppressor in endometrial cancer2010

    • Author(s)
      阪埜浩司
    • Organizer
      第69回日本癌学会学術総会
    • Place of Presentation
      大阪国際コンベンションセンター(大阪)
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 子宮体癌培養細胞株を用いたエピジェネティックに制御される癌抑制遺伝子として機能する microRNA の検索2010

    • Author(s)
      阪埜 浩司
    • Organizer
      第62回日本産科婦人科学会学術講演会
    • Place of Presentation
      東京
    • Year and Date
      2010-04-23
    • Related Report
      2012 Final Research Report
  • [Presentation] Aberrant epigenetic DNA hypermethylation in liquid-based endometrial cytology samples: evaluation and potential use in diagnosis.

    • Author(s)
      阪埜 浩司
    • Organizer
      37th Europian congress of Cytology
    • Place of Presentation
      クロアチア(ドブロブニク)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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