endometrial cancer therapy using epigenetically regulated small RNA

• Project/Area Number: 22591866
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
• Co-Investigator(Kenkyū-buntansha): YANOKURA Megumi 慶應義塾大学, 医学部, 特任助教 (20433732)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 婦人科腫瘍学 / 子宮体癌 / CHFR / miR-34b / タキサン製剤 / パクリタキセル / miRNA / メチル化 / エピジェネティック / siRNA

Research Abstract

It is revealed that CHFR gene is epigenetically regulated in endometrial cancer. CHFR gene methylation is correlated with response to Taxane. Micro RNA is also regulated by DNA methylation in endometrial cancer. miR-34b is important for the oncogenesis of

Research Products

• [Journal Article] MicroRNAs in endometrial cancer. (2013)
  • Author(s): Banno K, Yanokura M, Kisu I, Yamagami W, Susumu N, Aoki D
  • Journal Title: International journal of clinical oncology Volume: 18 Issue: 2 Pages: 186-192
  • DOI: 10.1007/s10147-013-0526-9
  • NAID: 10031176254
  • Peer Reviewed
• [Journal Article] Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics. (2012)
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
  • Journal Title: Biochemistry Research International Volume: 2012 Pages: 738274-738274
  • DOI: 10.1155/2012/738274
  • Peer Reviewed
• [Journal Article] Epigenetics and genetics in endometrial cancer: new carcinogenic mechanisms and relationship with clinical practice. (2012)
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
  • Journal Title: Epigenomics Volume: 4 Issue: 2 Pages: 147-162
  • DOI: 10.2217/epi.12.13
  • Peer Reviewed
• [Journal Article] Epigenetics and genetics in endometrial cancer : new carcinogenic mechanisms and relationship with clinical practice (2012)
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Ueki A, Kobayashi Y, Susumu N, Aoki D
  • Journal Title: Epigenomics Volume: 4 Pages: 147-162
  • Peer Reviewed
• [Journal Article] Flexible hysteroscopy with narrow band imaging (NBI) for endoscopic diagnosis of malignant endometrial lesions. (2011)
  • Author(s): 木須伊織
  • Journal Title: International Journal of Oncology Volume: 38(3) Pages: 613-618
  • Peer Reviewed
• [Journal Article] MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review) (2010)
  • Author(s): Yanokura M, Banno K, Kobayashi Y, Kisu I, Ueki A, Ono A, Masuda K, Nomura H, Hirasawa A, Susumu N, Aoki D
  • Journal Title: Oncol Lett Volume: 1(6) Pages: 935-940
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22870090
  • Peer Reviewed
• [Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA and microRNA by Epigenetics
  • Author(s): Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
  • Journal Title: Biochemistry Research International Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Biomarkers in Endometrial Cancer : Possible clinical applications
  • Author(s): Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
  • Journal Title: Oncology Letters Volume: (Review)(印刷中)
  • Peer Reviewed
• [Presentation] Aberrant epigenetic DNA hypermethylation in liquid-based endometrial cytology samples: evaluation and potential use in diagnosis. (2012)
  • Author(s): 阪埜 浩司
  • Organizer: 37th Europian congress of Cytology
  • Place of Presentation: ドブロブニク(クロアチア)
  • Year and Date: 2012-10-01
• [Presentation] 子宮体癌に対する miR-34b とパクリタキセル併用による抗腫瘍効果の検討 (2012)
  • Author(s): 矢野倉 恵
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-21
• [Presentation] 子宮体癌においてエピジェネティックに制御される miR-34b の同定とその癌抑制効果 (2012)
  • Author(s): 矢野倉 恵
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
  • Year and Date: 2012-04-13
• [Presentation] 専攻医教育プログラム 卵巣がん (2012)
  • Author(s): 阪埜 浩司
  • Organizer: 第64回日本産科婦人科学会学術講演会
  • Place of Presentation: 神戸
  • Year and Date: 2012-04-13
• [Presentation] 子宮体癌においてエピジェネティックに制御されるmiR-34bの同定とその癌抑制効果 (2012)
  • Author(s): 矢野倉恵
  • Organizer: 日本産科婦人科学会
  • Place of Presentation: 神戸国際展示場(神戸)(発表確定)
  • Year and Date: 2012-04-13
• [Presentation] A microRNA that is epigeneticcaly regulated and functions as a tumor suppressor in endometrial cancer (2010)
  • Author(s): 阪埜浩司
  • Organizer: 第69回日本癌学会学術総会
  • Place of Presentation: 大阪国際コンベンションセンター(大阪)
  • Year and Date: 2010-09-22
• [Presentation] 子宮体癌培養細胞株を用いたエピジェネティックに制御される癌抑制遺伝子として機能する microRNA の検索 (2010)
  • Author(s): 阪埜 浩司
  • Organizer: 第62回日本産科婦人科学会学術講演会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-23
• [Presentation] Aberrant epigenetic DNA hypermethylation in liquid-based endometrial cytology samples: evaluation and potential use in diagnosis.
  • Author(s): 阪埜 浩司
  • Organizer: 37th Europian congress of Cytology
  • Place of Presentation: クロアチア（ドブロブニク）