endometrial cancer therapy using epigenetically regulated small RNA
| Project/Area Number |
22591866
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
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| Co-Investigator(Kenkyū-buntansha) |
YANOKURA Megumi 慶應義塾大学, 医学部, 特任助教 (20433732)
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|---|
| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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|---|
| Keywords | 婦人科腫瘍学 / 子宮体癌 / CHFR / miR-34b / タキサン製剤 / パクリタキセル / miRNA / メチル化 / エピジェネティック / siRNA |
|---|
| Research Abstract |
It is revealed that CHFR gene is epigenetically regulated in endometrial cancer. CHFR gene methylation is correlated with response to Taxane. Micro RNA is also regulated by DNA methylation in endometrial cancer. miR-34b is important for the oncogenesis of
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics.2012
Author(s)
Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
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Journal Title
Biochemistry Research International
Volume: 2012
Pages: 738274-738274
DOI
Related Report
Peer Reviewed
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[Journal Article] MicroRNA and endometrial cancer: Roles of small RNAs in human tumors and clinical applications (Review)2010
Author(s)
Yanokura M, Banno K, Kobayashi Y, Kisu I, Ueki A, Ono A, Masuda K, Nomura H, Hirasawa A, Susumu N, Aoki D
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Journal Title
Oncol Lett
Volume: 1(6)
Pages: 935-940
URL
Related Report
Peer Reviewed
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[Journal Article] Endometrial Cancer and Hypermethylation : Regulation of DNA and microRNA by Epigenetics
Author(s)
Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
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Journal Title
Biochemistry Research International
Volume: (印刷中)
Related Report
Peer Reviewed
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[Journal Article] Biomarkers in Endometrial Cancer : Possible clinical applications
Author(s)
Banno K, Kisu I, Yanokura M, Tsuji K, Masuda K, Ueki A, Kobayashi Y, Yamagami W, Nomura H, Tominaga E, Susumu N, Aoki D
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Journal Title
Oncology Letters
Volume: (Review)(印刷中)
Related Report
Peer Reviewed
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