Alteration of tumor immunity and anti-cancer drug / hormone sensitivity accompanied by MMR mechanism abnormality in endometrial cancer
| Project/Area Number |
22591867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
BANNO Kouji 慶應義塾大学, 医学部, 講師 (70265875)
HIRASAWA Akira 慶應義塾大学, 医学部, 助教 (90296658)
YAMAGAMI Wataru 慶應義塾大学, 医学部, 助教 (30348718)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 婦人科腫瘍学 / 子宮内膜癌 / 腫瘍免疫 / MMR機構 / ホルモン感受性 / 黄体ホルモン療法 |
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| Research Abstract |
We detected that those cases with endometrial cancer with many infiltrative regulatory T cells (Treg) were significantly poorly-differentiated or advanced-stage cancer and had poor prognosis, and that those cases with high Treg/CD8 ratio had poor prognosi
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Report
(4 results)
Research Products
(81 results)
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[Journal Article] Endometrial Cancer and Hypermethylation: Regulation of DNA and MicroRNA by Epigenetics.2012
Author(s)
Banno K, Kisu I, Yanokura M, Masuda K, Kobayashi Y, Ueki A, Tsuji K, Yamagami W, Nomura H, Susumu N, Aoki D
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Journal Title
Biochemistry Research International
Volume: 2012
Pages: 738274-738274
DOI
Related Report
Peer Reviewed
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[Journal Article] Preoperative differential diagnosis of minimal deviation adenocarcinoma and lobular end cervical glandular hyperplasia of the uterine cervix : a multicenter study of clinico pathology and magnetic resonance imaging findings2011
Author(s)
Takatsu A, Shiozawa T, Miyamoto T, Kurosawa K, Kashima H, Yamada T, Kaku T, Mikami Y, Kiyokawa T, Tsuda H, Ishii K, Togashi K, Koyama T, Fujinaga Y, Kadoya M, Hashi A, Susumu N, Konishi I.
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Journal Title
Int J Gynecol Cancer
Volume: 21(7)
Pages: 1287-96
DOI
Related Report
Peer Reviewed
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