Research on the role of βadrenergic receptors in pathogenesis of Meniere's disease
| Project/Area Number |
22591883
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Otorhinolaryngology
|
|---|
| Research Institution | Kagawa University |
|---|
Principal Investigator |
MORI Nozomu 香川大学, 医学部, 教授 (90124883)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
MIYASHITA Takenori 香川大学, 医学部, 助教 (60363214)
AKIYAMA Kosuke 香川大学, 医学部附属病院, 助教 (40568838)
INAMOTO Ryuhei 香川大学, 医学部附属病院, その他 (50581047)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
MATSUBARA Ai
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | メニエール病 / β受容体 / 内リンパ嚢 / 内リンパ圧 / ストレス / ラット内リンパ嚢 / 上皮細胞 / 中間部 / アドレナリン受容体 / RT-PCR / 免疫組織学 / β_2-AR / β_3-AR / βアドレナリン受容体 / カテコールアミン / βアゴニスト / 内耳圧 |
|---|
| Research Abstract |
The results that catecholamines increased endolymphatic hydropressure in the cochlea and semicircular canalin the normal guinea pigs but not in the guinea pigs with obstructed endolymphatic sac (ES) strongly suggest the involvement of ES in increased endolymphatic hydropressure by catecholamines. The findings that catecholamines increased endolymphatic hydropressure in the cochlea to a larger degree than that in the semicircular canalcorrespond to clinical findings that Meniere patients suffer more frequently from the cochlear symptoms than the vestibular symptoms. The strong expression of β2-adrenergic receptor in epithelial cells of the ES intermediate portion accords with the electrophysiological results that catecholamines decrease ES direct current potentialvia β2-action.
|
Report
(4 results)
Research Products
(16 results)
