• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of calcium-permeable channels in marginal cells on the regulation of endocochlear potential.

Research Project

Project/Area Number 22591892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKansai University of Welfare Sciences (2011-2013)
Osaka Medical College (2010)

Principal Investigator

MORI Yoshiaki  関西福祉科学大学, 保健医療学部, 教授 (70268192)

Co-Investigator(Kenkyū-buntansha) MORI Atsuko  大阪医科大学, 医学部, 助教 (40368105)
INUI Takaki  大阪医科大学, 医学部, 助教 (60465614)
YAMAJI Junko  関西福祉科学大学, 健康福祉学部, 准教授 (40340559)
萩森 伸一  大阪医科大学, 医学部, 准教授 (90291799)
窪田 隆裕  大阪医科大学, 医学部, 教授 (10084906)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords蝸牛内直流電位 / 辺縁細胞 / 細胞内情報伝達機構 / L型カルシウムチャネル / Cキナーゼ / フォスフォリパーゼC / 細胞内Ca2+濃度 / L型Ca2+チャネル / PKC / PLC / サイクリックヌクレオチド / 細胞内Ca2+ / イオンチャネル / 血管条辺縁細胞 / 細胞内カルシウム / L型Ca^<2+>チャネル / プロティンキナーゼC / アミロリド / ロティンキナーゼC
Research Abstract

A large positive potential in the endolymph, named the endocochlear potential (EP) has been considered to occur at cochlear stria vascularis. In the previous study, we reported that the decrease in EP induced by transient asphyxia was result from the increase in intracellular calcium ion induced by the activation of L-type calcium channels in the basolateral membrane of the marginal cells. In the present study, we demonstrated that a fall in the EP induced by transient asphyxia was suppressed by the administration of calcium-chelator, L-type calcium channel inhibitor, C kinase (PKC) inhibitors, or phospholipase C (PLC) inhibitors to the endolymph. Thus, asphyxia induced decrease in the EP was induced by the increase in calcium ion in the cells of stria vascularis, through the activation of L-type calcium channels mediated by the PKC activation result from the PLC activation.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (44 results)

All 2014 2013 2012 2011 2010

All Journal Article (16 results) (of which Peer Reviewed: 6 results) Presentation (25 results) Book (3 results)

  • [Journal Article] 顔面神経減荷術の聴力に対する影響2013

    • Author(s)
      森京子,萩森伸一,櫟原崇宏,金沢敦子,松村麗,河田了
    • Journal Title

      Facial N Res Jpn

      Volume: 33 Pages: 126-128

    • Related Report
      2013 Final Research Report
  • [Journal Article] 正中法ElectroneurographyにおけるCMAP潜時の検討2013

    • Author(s)
      和田晋一,萩森伸一,森京子,金沢敦子,櫟原崇宏,野中隆三郎,河田了,藤岡重和
    • Journal Title

      Facial N Res Jpn

      Volume: 33 Pages: 89-91

    • Related Report
      2013 Final Research Report
  • [Journal Article] GABAB receptor immunopositive cells found in the mouse pulmonary alveolar epithelium were Type II cells2013

    • Author(s)
      Watanabe M, Ito Y, Fujioka S, Mori Y
    • Journal Title

      J. Allied Health Sci

      Volume: 4(2) Pages: 35-41

    • Related Report
      2013 Final Research Report
  • [Journal Article] Macrophage MHC and T-cell receptors essential for rejection of allografted skin and lymphoma2013

    • Author(s)
      Tashiro-Yamaji J, Maeda S, Ikawa M, Okabe M, Kubota T and Yoshida R
    • Journal Title

      Transplantation

      Volume: 96(3) Pages: 251-257

    • Related Report
      2013 Final Research Report
  • [Journal Article] GABAB receptor immunopositive cells found in the mouse pulmonary alveolar epithelium were Type II cells.2013

    • Author(s)
      Watanabe M., Ito Y., Fujioka S., Mori Y.
    • Journal Title

      Journal of Allied Health Science

      Volume: 4 (2) Pages: 17-23

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 太極拳ゆったり体操の3ヶ月継続は心臓足首血管指数を改善するか? 無作為化比較試験2013

    • Author(s)
      森 耕平,野村卓生,明崎禎輝,片岡紳一郎,中俣恵美,浅田史成,森 禎章,甲斐 悟,渡辺正仁
    • Journal Title

      運動疫学研究

      Volume: 15 (2) Pages: 71-81

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Specific binding of HLA-B44 to human macrophage MHC receptor 1 on monocytes2012

    • Author(s)
      Tashiro-Yamaji J, Shimizu T, Hayashi M, Yamana H, Tanigawa N, Uchiyama K, Kubota T and Yoshida R
    • Journal Title

      Gene

      Volume: 501(2) Pages: 127-134

    • Related Report
      2013 Final Research Report
  • [Journal Article] Electroneurography(ENoG)における神経刺激電極位置についての検討2012

    • Author(s)
      和田晋一,萩森伸一,森京子,金沢敦子,櫟原崇宏,野中隆三郎,河田了,藤岡重和
    • Journal Title

      Facial Nerve Research

      Volume: 32 Pages: 122-124

    • Related Report
      2013 Final Research Report
  • [Journal Article] クリニカルクラークシップにおけるSignificant Event Analysisのエベントについての検討 テキストマイニングにより抽出された学習カテゴリについて.2012

    • Author(s)
      宮本 学
    • Journal Title

      大阪医科大学雑誌

      Volume: 71 Pages: 19-27

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of GABA system in mouse olfactory mucosa2011

    • Author(s)
      Watanabe M, Mori Y, Watanabe K, Hiroshima R, Fujioka S, and Yanagawa Y
    • Journal Title

      J. Allied Health Sci

      Volume: 2 Pages: 84-89

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of the GABAA receptor/chloride channel in murine speratogenic cells2011

    • Author(s)
      Kanbara K, Mori Y, Kubota T, Watanabe M, Yanagawa Y, and Otsuki Y
    • Journal Title

      Histol Histopathol

      Volume: 26 Pages: 95-106

    • Related Report
      2013 Final Research Report
  • [Journal Article] 糖尿病を合併する顔面神経麻痺および突発性難聴患者に対するステロイド大量投与の糖尿病への影響について2011

    • Author(s)
      森京子,萩森伸一,金沢敦子,櫟原崇宏,河田了
    • Journal Title

      Facial N Res Jpn

      Volume: 31 Pages: 49-51

    • NAID

      10027667744

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of GABA system in Mouse Olfactory Mucosa2011

    • Author(s)
      Watanabe M, et al
    • Journal Title

      J.Allied Health Sci

      Volume: 2 Pages: 86-89

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 医学部学生のカリキュラム・教育体制・環境に対する満足度についての検討第6学年始業時の満足度測定調査の分析2011

    • Author(s)
      宮本学, 他
    • Journal Title

      大阪医科大学雑誌

      Volume: 70(2) Pages: 84-97

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel electroneurography method in facial palsy2010

    • Author(s)
      Haginomori S, Wada S, Takamaki A, Kanazawa A, Nonaka R, Takenaka H, Takubo T
    • Journal Title

      Acta Otolaryngol

      Volume: 130 Pages: 520-524

    • Related Report
      2013 Final Research Report
  • [Journal Article] Expression of the GABA_A receptor/chloride channel in murine spermatogenic cells.2010

    • Author(s)
      Kanbara K, Mori Y, Kubota T, Watanabe M, Yanagawa Y, Otsuki Y.
    • Journal Title

      Histol Histopathol

      Volume: 26 Pages: 95-106

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 2. 筋萎縮からの回復において3種の治療法が筋タンパク質に与える影響.2014

    • Author(s)
      廣島玲子,森 禎章,山本真紀,早崎 華,山路純子,渡辺正仁
    • Organizer
      第4回総合福祉学学会
    • Place of Presentation
      柏原
    • Related Report
      2013 Annual Research Report
  • [Presentation] リハビリテーションと先端医療の最前線-骨格筋細胞増殖過程における細胞内情報伝達機構の役割-2013

    • Author(s)
      森禎章,山路純子,山本真紀,廣島玲子,中野禎,渡辺正仁
    • Organizer
      第3回日総合福祉学学会・シンポジウム「リハビリテーション最前線」
    • Place of Presentation
      柏原
    • Year and Date
      2013-03-06
    • Related Report
      2013 Final Research Report
  • [Presentation] Ca^2+-calmodulin/ calcineurin mediated signaling pathways are essential for upregulation of MHC I mRNA level in C2C12 cells2013

    • Author(s)
      Mori Y, Yamamoto M, Hiroshima R, Nakano T, and Watanabe M
    • Organizer
      XXXVII Congress of the International Union of Physiological Science
    • Place of Presentation
      Birmingham
    • Related Report
      2013 Final Research Report
  • [Presentation] 一側性メニエール病における聴力低下時の頭振り眼振所見と聴力の短期予後の関係2013

    • Author(s)
      乾崇樹,萩森伸一,松村麗,長谷川恵子,森京子,櫟原崇宏,金沢敦子,藤山吉更,荒木倫利,河田了
    • Organizer
      第114回日本耳鼻咽喉科学会総会
    • Place of Presentation
      札幌
    • Related Report
      2013 Final Research Report
  • [Presentation] Ca2+-calmodulin/ calcineurin mediated signaling pathways are essential for upregulation of MHC I mRNA level in C2C12 cells.2013

    • Author(s)
      Mori Y., Yamamoto M., Hiroshima R., Nakano T., and Watanabe M
    • Organizer
      XXXVII Congress of the International Union of Physiological Science.
    • Place of Presentation
      バーミンガム
    • Related Report
      2013 Annual Research Report
  • [Presentation] リハビリテーションと先端医療の最前線-骨格筋細胞増殖過程における細胞内情報伝達機構の役割-2013

    • Author(s)
      森 禎章
    • Organizer
      第3回日総合福祉学学会・シンポジウム
    • Place of Presentation
      柏原
    • Related Report
      2012 Annual Research Report
  • [Presentation] Effect of intracellular Ca2+ on myosin heavy chain I, HSP70, and IL-6 mRNA levels in C2C12 cells.2013

    • Author(s)
      Yoshiaki Mori
    • Organizer
      第90回日本生理学会大会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of PLC/PKC signaling cascade on the decrease in endocochlear potential induced by transient asphyxia2012

    • Author(s)
      Mori Y, et al
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本市・長野県松本文化会館
    • Year and Date
      2012-03-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] PKC-dependent Phosphorylation Processes Contribute to the Decrease in the Endocochlear Potential induced by the Transient Asphyxia2012

    • Author(s)
      Inui T, Takamaki-Mori A, Hasegawa-Tsujimura K, Haginomori S, Kawata R, and Mori Y
    • Organizer
      The First Asian Otology Meeting & The 3^<rd> East Asian Symposium on Otology
    • Place of Presentation
      Nagasaki
    • Related Report
      2013 Final Research Report
  • [Presentation] 一側性メニエール病における聴力低下時の頭振り眼振所見と聴力の短期予後の関係2012

    • Author(s)
      乾崇樹,萩森伸一,松村麗,長谷川恵子,森京子,櫟原崇宏,金沢敦子,藤山吉更,荒木倫利,河田了
    • Organizer
      第113回日本耳鼻咽喉科学会総会
    • Place of Presentation
      新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] Role of PLC/PKC signaling cascade on the decrease in endocochlear potential induced by transient asphyxia2012

    • Author(s)
      Mori Y, Inui T, Takamaki-Mori A, Hasegawa-Tsujimura K, Tashiro-Yamaji J, Watanabe M, Kawata R, and Kubota T
    • Organizer
      第89回日本生理学会大会
    • Place of Presentation
      松本
    • Related Report
      2013 Final Research Report
  • [Presentation] PKC-dependent Phosphorylation Processes Contribute to the Decrease in the Endocochlear Potential induced by the Transient Asphyxia.2012

    • Author(s)
      Takaki Inui
    • Organizer
      The First Asian Otology Meeting & The 3rd East Asian Symposium on Otology
    • Place of Presentation
      Nagasaki
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of L-type Ca2+ channels in marginal cells of the stria vascularis during transient asphyxia2011

    • Author(s)
      Inui T, et al
    • Organizer
      11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      神戸市・ANAクラウンプラザホテル
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of L-type Ca^<2+> channels in marginal cells of the stria vascularis during transient asphyxia2011

    • Author(s)
      Inui T, Mori Y, Watanabe M, Hasegawa-Tsujimura K, Takamaki-Mori A, Haginomori S, Kubota T, and Kawata T
    • Organizer
      11^<th> Japan-Taiwan Conference on Otolaryngology-Head and Neck Surgery
    • Place of Presentation
      Kobe
    • Year and Date
      2011-12-08
    • Related Report
      2013 Final Research Report
  • [Presentation] 無呼吸負荷によるモルモット内リンパ直流電位と蝸牛管上皮抵抗の変化2011

    • Author(s)
      長谷川恵子, 他
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      宜野湾市・沖縄コンベンションセンター
    • Year and Date
      2011-11-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] メニエール病における頭振り眼振所見の検討2011

    • Author(s)
      乾崇樹,萩森伸一,松村麗,辻村恵子,櫟原崇宏,藤山吉更,金沢敦子,森京子,荒木倫利,河田了
    • Organizer
      第70回日本めまい平衡以外句会総会
    • Place of Presentation
      千葉
    • Year and Date
      2011-11-17
    • Related Report
      2013 Final Research Report
  • [Presentation] 大阪医大耳鼻科で治療した中耳真珠腫の進展度と手術成績について2011

    • Author(s)
      森京子,萩森伸一,櫟原崇宏,金沢敦子,河田了
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      沖縄
    • Related Report
      2013 Final Research Report
  • [Presentation] 蝸牛内直流電位のプロテインキナーゼC依存性蛋白燐酸化過程による調節機構2011

    • Author(s)
      乾崇樹,森禎章,森京子,長谷川恵子,萩森伸一,窪田隆裕,河田了
    • Organizer
      第112回日本耳鼻咽喉科学会総会
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] 無呼吸負荷による蝸牛内直流電位低下におけるPKC依存性蛋白燐酸化過程の関与2010

    • Author(s)
      森禎章, 他
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      松山市・ひめぎんホール
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 蝸牛内直流電位の維持に対する血管条辺縁細胞のCa^<2+>透過性チャネルの役割2010

    • Author(s)
      乾崇樹, 他
    • Organizer
      第21回日本耳科学会総会
    • Place of Presentation
      松山市・ひめぎんホール
    • Year and Date
      2010-10-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Isolation of a human cDNA homologous to a mouse cDNA encoding a receptor for allogeneic MHC (H-2 D^d)[macrophage MHC receptor 1 (MMR 1)]2010

    • Author(s)
      Tashiro-Yamaji J, Shimizu T, Inoue Y, Kubota T, Yoshida R
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-25
    • Related Report
      2013 Final Research Report
  • [Presentation] PKC-dependent phosphorylation pathway(s) contribute to the decrease in endocochlear potential induced by the transientasphyxia2010

    • Author(s)
      Mori Y, Takamaki-Mori A, Inui T, Hasegawa K, Tashiro-Yamaji J, Miyamoto M, and Kubota T
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡
    • Year and Date
      2010-05-19
    • Related Report
      2013 Final Research Report
  • [Presentation] PKC-dependent phosphprylation pathway(s) contribute to the decrease in endocochlear potential induced by the transient asphyxia.2010

    • Author(s)
      Mori Y, et al.
    • Organizer
      第87回日本生理学会大会
    • Place of Presentation
      盛岡市・盛岡市民文化ホール(マリオス)
    • Year and Date
      2010-05-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] 無呼吸負荷による蝸牛内直流電位低下におけるPKC依存性蛋白燐酸化過程の関与2010

    • Author(s)
      森禎章,乾崇樹,森京子,長谷川恵
子,荒木倫利,萩森伸一,河田了,窪田隆裕
    • Organizer
      第20回日本耳科学会総会
    • Place of Presentation
      松山
    • Related Report
      2013 Final Research Report
  • [Presentation] 蝸牛内直流電位の維持に対する血管条辺縁細胞のCa2+透過性チャネルの役割2010

    • Author(s)
      乾崇樹,森禎章,森京子,渡辺
正仁,長谷川恵子,荒木倫利,萩森伸一,窪田隆裕,河田了
    • Organizer
      第20回日本耳科学会総会
    • Place of Presentation
      松山
    • Related Report
      2013 Final Research Report
  • [Book] 超カラー図解看護自己学習解剖生理学2013

    • Author(s)
      渡辺正仁,森禎章
    • Publisher
      金芳堂
    • Related Report
      2013 Final Research Report
  • [Book] 超カラー図解 看護自己学習 解剖生理学2013

    • Author(s)
      渡辺正仁,森 禎章
    • Total Pages
      323
    • Publisher
      金芳堂
    • Related Report
      2013 Annual Research Report
  • [Book] 医療福祉系学生のための専門基礎科目 改訂2版2013

    • Author(s)
      河野公一
    • Total Pages
      697
    • Publisher
      金芳堂
    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi