Neuroprotective effect of an antioxidant, lutein in the retina of a murine model of diabetes.

• Project/Area Number: 22591950
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: SASAKI Mariko 慶應義塾大学, 医学部, 特任助教 (60276342)
• Co-Investigator(Kenkyū-buntansha): OZAWA Yoko 慶應義塾大学, 医学部, 講師 (90265885)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 網膜神経保護 / 抗酸化剤 / ルテイン / 糖尿病 / 網膜神経変性 / 酸化ストレス / 神経保護 / 網膜

Research Abstract

Diabetic retinopathy is a progressive neurodegenerative disease, but the underlying mechanism is still obscure. Here, we focused on oxidative stress in the retina, and analysed its influence on retinal neurodegeneration, using an antioxidant, lutein. Lute

Research Products

• [Journal Article] Neuroprotective effects of lutein in the retina. (2012)
  • Author(s): Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K
  • Journal Title: Curr Pharm Des Volume: 18(1) Pages: 51-6
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of lutein in the retina. (2012)
  • Author(s): Ozawa Y, Sasaki M, Takahashi N, Kamoshita M, Miyake S, Tsubota K.
  • Journal Title: Curr Pharm Des. Volume: 18 Pages: 51-56
  • Peer Reviewed
• [Journal Article] Neural degeneration in the retina of the streptozotocin-induced type 1 diabetes model. (2011)
  • Author(s): Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K. Exp Diabetes Res.
  • Journal Title: Epub 2011 Volume: Nov 17 Pages: 108328-108328
  • Peer Reviewed
• [Journal Article] Neural degeneration in the retina of the streptozotocin(STZ)-induced type 1 diabetes model (2011)
  • Author(s): Ozawa Y, Kurihara T, Sasaki M, Ban N, Yuki K, Kubota S, Tsubota K
  • Journal Title: Experimental Diabetes Research 2011 Volume: 2011 Pages: 108328-108328
  • DOI: 10.1155/2011/108328
  • Peer Reviewed
• [Journal Article] Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. (2010)
  • Author(s): Sasaki M, Ozawa Y, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K.
  • Journal Title: Diabetologia Volume: 53(5) Pages: 971-9
  • Peer Reviewed
• [Journal Article] Neurodegenerative influence of oxidative stress in the retina of a murine model of diabetes. (2010)
  • Author(s): Sasaki M
  • Journal Title: Diabetologia Volume: 53 Pages: 971-979
  • Peer Reviewed
• [Journal Article] Retinal aging and sirtuins. (2010)
  • Author(s): Ozawa Y, Sasaki M
  • Journal Title: Ophthalmic Res. Volume: 44 Pages: 199-203
  • Peer Reviewed
• [Journal Article] Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation. (2010)
  • Author(s): Kubota S, Sasaki M
  • Journal Title: Am J Pathol. Volume: 177 Pages: 1725-1731
  • Peer Reviewed
• [Presentation] Neuroprptective effect of an antioxidant lutein in the diabetic retina (2011)
  • Author(s): Sasaki M, Yuki K, Kubota S, Miyake S, Kobayashi S, Ishida S, Tsubota K, Ozawa Y
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2011-05-02
• [Presentation] Neuroprotective effect of an antioxidant lutein in the diabetic retina (2011)
  • Author(s): 佐々木真理子、小沢洋子, 他
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO) Annual Meeting
  • Place of Presentation: Fort Lauderdale, USA
• [Presentation] Neuroprotective effect of an antioxidant lutein from Light-Induced Retinal Degeneration (2010)
  • Author(s): M.Sasaki
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2010-05-03
• [Remarks]
  • URL: http://www.keio-eye.net
• [Remarks]
  • URL: http://www.keio-eye.net/