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Mineralocorticoid receptor blockade attenuates proliferative changes in the rat pulmonary artery in monocrotaline-induced pulmonary hypertension

Research Project

Project/Area Number 22591987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionOsaka Medical College

Principal Investigator

NEMOTO SHINTAROU  大阪医科大学, 医学部, 准教授 (20237811)

Co-Investigator(Kenkyū-buntansha) TERASAKI Fumio  大阪医科大学, 医学部・内科学3, 准教授 (20236988)
TAKAI Shinji  大阪医科大学, 薬理学, 准教授 (80288703)
KISHI Kanta  大阪医科大学, 小児科学, 助教 (20408503)
MORI Yasuhiko  大阪医科大学, 小児科学, 助教 (20287345)
Co-Investigator(Renkei-kenkyūsha) OKUMURA Kenichi  大阪医科大学, 小児科学, 助教 (10349699)
HAMORI Kan  大阪医科大学, リハビリテーション医学, 助教 (90581207)
Project Period (FY) 2010-04-01 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords肺高血圧 / ミネラロコルチコイド受容体 / ミネラロコルチコイド受容体拮抗剤 / エプレレノン / 治療 / 肺高血圧症 / アルドステロン / ミネラルコクチコイド受容体 / 心臓手術
Research Abstract

The aim of this study was to investigate a role of mineralocorticoid receptor (MR) signaling in the arteriolar remodeling of pulmonary artery hypertension (PAH) by antagonizing MR.
PAH was induced by a single subcutaneous injection of monocrotaline in male rats. Animals were divided in two groups: one group treated with oral MR antagonist and the other received no medication. MR antagonist treatment ameliorated increased reduced RV function and hypertrophy caused by elevated peak RV pressure seen in the group with no medication. The treatment group showed significantly less medial wall thickness and muscularization of PA compared to the group with no medication. MR antagonist treatment resulted in significant reduction in the mRNA levels of the MR, angiotensin 2 type 1a receptor and transforming growth factor beta1 in the lungs, when compared to the group with no medication.
These results suggest that MR signaling plays a role in the proliferative vascular remodeling of PAH.

Report

(4 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (9 results)

All 2014 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (5 results) Remarks (1 results)

  • [Journal Article] Monocrotaline誘発肺高血圧ラットにおける肺小動脈リモデリング形成過程におけるMineralocorticoid receptor拮抗剤eplerenoneの効果2014

    • Author(s)
      羽森貫、根本慎太郎、佐々木智康、勝間田敬弘、岸勘太、奥村謙一、尾崎智康、片山博視
    • Journal Title

      日本小児循環器学会誌

      Volume: 第30巻, (印刷中)

    • NAID

      130004684473

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Monocrotaline誘発肺高血圧ラットにおける肺小動脈リモデリング形成過程におけるMineralocorticoid receptor 拮抗剤eplerenoneの効果2014

    • Author(s)
      羽森 貫、根本慎太郎、佐々木智康、勝間田敬弘、岸勘太、奥村謙一、尾崎智康、片山博視
    • Journal Title

      日本小児循環器学会雑誌

      Volume: 印刷中

    • NAID

      130004684473

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モノクロタリン誘発肺高血圧ラットに対するエプレレノンの効果2010

    • Author(s)
      羽森貫
    • Journal Title

      大阪医科大学雑誌

      Volume: 第69巻 Pages: 11-31

    • NAID

      40017239243

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] 持続的低酸素曝露に伴う心室リモデリングにおけるVEGFの意義と重要性2012

    • Author(s)
      禹 英喜、根本慎太郎、勝間田敬弘、林 哲也
    • Organizer
      第35回日本高血圧学会総会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 持続的低酸素曝露に伴う心室リモデリングにおけるVEGFの意義と重要性2012

    • Author(s)
      禹 英喜、根本慎太郎、勝間田敬弘、林 哲也
    • Organizer
      第65回日本胸部外科学会定期学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] モノクロタリン誘発肺高血圧ラットに対するエプレレノンの効果2011

    • Author(s)
      羽森貫、佐々木智康、禹英喜、垣田真理、岸勘太、奥村謙一、森保彦、勝間田敬弘、根本慎太郎
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2011-07-06
    • Related Report
      2013 Final Research Report
  • [Presentation] モノクロタリン誘発肺高血圧ラットに対するエプレレノンの効果2011

    • Author(s)
      羽森貫
    • Organizer
      第47回日本小児循環器学会総会・学術集会
    • Place of Presentation
      福岡国際会議場
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mineralocorticoid receptor blockade attenuates proliferative changes in the rat pulmonary artery in monocrotaline-induced pulmonary hypertension. American Heart Association2010

    • Author(s)
      Kan Hamori, Shintaro Nemoto
    • Organizer
      Scientific Sessions
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2010-11-15
    • Related Report
      2013 Final Research Report
  • [Remarks] 大阪医科大学外科学講座胸部外科学教室 研究室ホームページ

    • URL

      http://www.osaka-med.ac.jp/deps/tho/guide/kiso02.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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