High quality cardiopulmonary-brain resuscitation with antioxidant administration just before starting resuscitation (Animal study)

Research Project

Project/Area Number	22592007
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Emergency medicine
Research Institution	International University of Health and Welfare
Principal Investigator	SHINOZAWA Yotaro 国際医療福祉大学, 大学病院, 教授 (30129465)
Co-Investigator(Kenkyū-buntansha)	NOMURA Ryosuke 東北大学, 大学病院, 助教 (90400358)
Project Period (FY)	2010 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000) Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	心肺停止 / 酸化 / 抗酸化 / 虚血再灌流 / 酸化ストレス度 / 抗酸化力 / 蘇生 / 虚血再潅流 / 抗酸化物質 / 虚血再還流 / 酸化抗酸化 / 動物モデル
Research Abstract	We devised brain ischemia and reperfusion animal (rat) model analogous to blood oxidative and anti-oxidative states observed in Vegetative State patients after cardiac and pulmonary arrest and resuscitation. In this model, Vitamin C 10mg and 20mg/body administrations just before reperfusion suppressed the increase of plasma reactive oxygen metabolites after the reperfusion and Vitamin C 20mg/body administration just before reperfusion increased the plasma biological antioxidant potential.