| Project/Area Number |
22592024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Emergency medicine
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| Research Institution | Kyoto University (2011-2012)
Nippon Medical School (2010) |
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Principal Investigator |
SATO Norio 京都大学, 大学院・医学研究科, 講師 (30409205)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAKAWA Keiko 日本医科大学, 医学部, 助教 (30165162)
KOIKE Kaoru 京都大学, 大学院・医学研究科, 教授 (10267164)
SUZUKI Takao 京都大学, 大学院・医学研究科, 講師 (40328810)
増野 智彦 日本医科大学, 医学部, 講師 (00318528)
横田 裕行 日本医科大学, 大学院・医学研究科, 教授 (60182698)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 敗血症 / 代謝動態 / 免疫調整栄養剤 / ホエイプロテイン / n-3系脂肪酸 / 核磁気共鳴像 / 栄養 / 全身性炎症性反応症候群 / エネルギー代謝 / 全身炎症性反応症候群 / 発熱 / エネルギーリン代謝 / 磁気共鳴画像 |
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| Research Abstract |
Sepsis is systemic inflammatory response syndrome (SIRS) caused by infection. Energy metabolism is remarkably aggravated and hyper catabolism resulted in protein breakdown. It is important to understand metabolic change in liver and muscle which are mainly related heat production. Nutrition is expected to suppress inflammatory reaction and improve metabolic changes. We successfully demonstrated metabolic changes between immune-modulating diet and control diet under septic insult using nuclear magnetic resonance.
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