| Project/Area Number |
22592027
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Emergency medicine
|
|---|
| Research Institution | National Defense Medical College |
|---|
Principal Investigator |
KINOSHITA Manabu 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (70531391)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SEKI Shuhji 防衛医科大学校, 医学教育部医学科専門課程, 教授 (80531392)
SAITOH Daizoh 防衛医科大学校, 防衛医学研究センター, 教授 (90531632)
ONO Satoshi 防衛医科大学校, 防衛医学研究センター, 准教授 (30531355)
MIYAZAKI Hiromi 防衛医科大学校, 防衛医学研究センター, 助教 (30531636)
SAKAMOTO Toshihisa 防衛医科大学校, 病院, 教授 (50178571)
NISHIKAWA Kahoko 防衛医科大学校, 病院, 助教 (20345416)
SHINOMIYA Nariyoshi 防衛医科大学校, 医学教育部医学科専門課程, 教授 (40505260)
|
|---|
| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 熱傷 / 複合免疫不全 / 好中球 / クッパー細胞 / 熱傷後感染 / IL-18 / CD68陽性クッパー細胞 / CD11b陽性クッパー細胞 / CD68陽性Kupffer細胞 / CD11b陽性Kupffer細胞 / 免疫不全 / 活性酸素 / マウス熱傷モデル / 細菌感染 / NK細胞 |
|---|
| Research Abstract |
Severely burn-injured hosts are known to be highly susceptible to bacterial infections/sepsis, and their outcomes become extremely poor due to infectious complications. Their host defense systems against infections, such as Th1-mediated cellular immunity, Th2-mediated humoral immunity and neutrophil-mediated immunity, are severely and multifactorially impaired. Multiple IL-18 injections can effectively restore these impaired immune responses in the immunocompromised mice receiving severe burn injury, thus improving their survival after bacterial infections. IL-18 therapy also restored burn injury-induced phenotypic alteration of Kupffer cells, namely increasing CD68+ Kupffer cells but decreasing CD11b+ Kupffer cells.
|
