| Project/Area Number |
22592034
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Osaka University |
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Principal Investigator |
|
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| Co-Investigator(Kenkyū-buntansha) |
OKURA Masaya 大阪大学, 大学院・歯学研究科, 准教授 (10281130)
MORII Eiichi 大阪大学, 大学院・歯学研究科, 教授 (10283772)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
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| Keywords | 扁平上皮癌 / 前癌病変 / HPV / 細胞診 / 免疫染色 / ＨＰＶ |
|---|
| Research Abstract |
The cytological diagnoses for about 100 cases of suspected squamous cell carcinomas or precancerous lesions were almost all correct. All of positive cases were squamous cell carcinomas, and negative cases were benign lesions. HPV-DNA was not detected in 50 cases of these lesions. Immunohistochemical double staining method was used for detecting p53 protein and p16 protein in cytological smears. The sensitivity of p53 positivity for detection of cancer cells was 30%, and its specificity was 100%. The sensitivity and specificity of p16 protein were not significant.
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