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A possible role of glucose transporters and monocarboxylate transporters in osteocytes during changes of extracellular milieus

Research Project

Project/Area Number 22592045
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionHealth Sciences University of Hokkaido

Principal Investigator

SAKAKURA Yasunori  北海道医療大学, 歯学部, 教授 (60128915)

Co-Investigator(Kenkyū-buntansha) IRIE Kazuharu  北海道医療大学, 歯学部, 教授 (70223352)
SHIBUI Toru  北海道医療大学, 歯学部, 助教 (80453265)
TAKAHASHI Masami  北海道医療大学, 歯学部, 助教 (50550307)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords骨芽細胞 / 骨細胞 / 軟骨細胞 / 低酸素応答因子 / ルコース輸送担体 / モノカルボン酸輸送担体 / グルコース輸送担体 / 免疫組織化学
Research Abstract

In alveolar bone of mouse mandibular bone, the structure of lamellar bone newly formed after bone remodeling was clearly different from that of older bone. It was observed by phalloidin stainingthat the network of bone canaliculi was not connected between the new bone and older bone. Osteocytes in the old bone showed positive staining of HIF-1α, HIF-2α, GLUT3 and MCT2, whereas those in the new bone was not stained. We conclude that osteocytes survive in a severe milieus through expression of HIFs, GLUTs and MCTs.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (10 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (7 results)

  • [Journal Article] Radiation protective effect of hypoxia-inducible factor-1α(HIF-1α) on humanoral squamous cell carcinoma cell lines2012

    • Author(s)
      Y. Hosokawa, K. Okumura, S. Terasima, Y. Sakakura
    • Journal Title

      Radiation Protection Dosimetry

      Volume: Vol. 152 Issue: 1-3 Pages: 159-163

    • DOI

      10.1093/rpd/ncs215

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] ヒト歯根膜由来線維芽細胞におけるfibllin-1の発現抑制がversicanのmRNAとタンパク質発現およびタンパク質の局在へ及ぼす影響2012

    • Author(s)
      永坂 萌、鳥谷奈保子、敦賀英知、坂倉康則、溝口 到
    • Journal Title

      北海道医療大学歯学雑誌

      Volume: 31巻 Pages: 19-26

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] hi Effect of the quantity and quality of cortical bone on the failure force of a miniscrew inplant2012

    • Author(s)
      M. Iijima, M. Takano, Y. Yasuda, T. Muguruma, S. Nakagaki, Y. Sakakura, I. Mizoguc
    • Journal Title

      European Journal of Orthdontics

      Volume: - Issue: 5 Pages: 583-589

    • DOI

      10.1093/ejo/cjs066

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] 骨細胞の細胞間ネットワークの断裂と低酸素応答因子・グルコース輸送担体・モノカルボン酸輸送担体の発現局在2013

    • Author(s)
      高橋昌己、渋井 徹、入江一元、坂倉康則
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Year and Date
      2013-03-29
    • Related Report
      2012 Final Research Report
  • [Presentation] マウス脛骨軟骨内骨化におけるグルコース輸送担体(GLUTs)とモノカルボン酸輸送担体(MCTs)の発現2012

    • Author(s)
      高橋昌己、坂倉康則、入江一元、渋井 徹
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Year and Date
      2012-10-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Glucose transports and monocarboxylate trasporters in developing endochondral bone in mice2011

    • Author(s)
      Masami Takahashi, et al.
    • Organizer
      第116回日本解剖学会全国学術集会
    • Place of Presentation
      J.Physiolocal Sciences(誌上発表)
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Glucose transporters and monocarboxylate transporters in developing endochondral bone of mice2011

    • Author(s)
      M. Takahashi, T. Shibui, K. Irie, Y. Sakakura
    • Organizer
      J. Physiol. Sci
    • Related Report
      2012 Final Research Report
  • [Presentation] ヒト歯根膜由来線維芽細胞の伸展刺激に対するfibllin-1とversicanの発現変化

    • Author(s)
      永坂 萌、鳥谷奈保子、敦賀英知、坂倉康則、溝口 到
    • Organizer
      第71回日本矯正歯科学会大会
    • Place of Presentation
      いわて県民情報交流センター(盛岡市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス脛骨軟骨内骨化におけるグルコース輸送担体(GLUTs)とモノカルボン酸輸送担体(MCTs)の発現

    • Author(s)
      高橋昌己、坂倉康則、入江一元、渋井 徹
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場(岐阜市)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 骨細胞の細胞間ネットワークの断裂と低酸素応答因子・グルコース輸送担体・モノカルボン酸輸送担体の発現局在

    • Author(s)
      高橋昌己、渋井徹、入江一元、坂倉康則
    • Organizer
      第118回日本解剖学会全国学術集会
    • Place of Presentation
      サンポートホール高松(香川県高松市)
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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