The function of PKR in differentiation of mesenchymal stem cells.
| Project/Area Number |
22592055
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HANEJI Tatsuji 徳島大学, 大学院HBS研究部, 教授 (50156379)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | PKR / 軟骨細胞分化 / 間葉系幹細胞 / ２本鎖RNA / 軟骨分化 / タンパク質相互作用 / BiFC法 / 2本鎖RNA / 蛋白質相互作用 / BiEC法 |
|---|
| Research Abstract |
An involvement of PKR in differentiation of mesenchymal stem cells has not been clarified yet. Our studies revealed that PKR regulated the differentiation of chondrocyte and osteoclast. The PKR expression reflected the differentiational stage of intestinal epithelial cells and stomach cancer cells. These results indicated that PKR played an important role on the differentiation of mesenchymal stem cells. The findings will contribute to better understanding of bone and cartilage associated disease and a discovery of therapeutic target.
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Report
(4 results)
Research Products
(84 results)
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[Journal Article] Regulation of actin dynamics by protein kinase R control of gelsolin enforces basal innate immune defense2012
Author(s)
Irving AT, Wang D, Vasilevski O, Latchoumanin O, Kozer N, Clayton AH, Szczepny A, Morimoto H, Xu D, Williams BR, Sadler AJ
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Journal Title
Immunity
Volume: 36(5)
Issue: 5
Pages: 795-806
DOI
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Peer Reviewed
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[Presentation] High glucose peritoneal dialysate induce apoptosis through endoplasmic reticulum stress in peritoneal mesothelial cells2012
Author(s)
Nakamata J, Morimoto H, Baba R, Ishimatsu N, Miyamoto T, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
49th ERA-EDTA (European Renal Association- European Dialysis and Transplant Association) Congress
Place of Presentation
Paris (France)
Related Report
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[Presentation] Pentraxin 3 Expression in a Rat Model of Continuous Peritoneal Dialysis2012
Author(s)
Ishimatsu N, Miyamoto T, Morimoto H, Nakamata J, Baba R, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
49th ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) Congress
Place of Presentation
Paris (France)
Related Report
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[Presentation] Pentraxin 3 Expression in a Rat Model of Continuous Peritoneal Dialysis2012
Author(s)
Ishimatsu N, Miyamoto T, Morimoto H, Nakamata J, Baba R, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M.
Organizer
49th ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) Congress
Place of Presentation
Palais des Congres (Paris, France)
Related Report
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[Presentation] High glucose peritoneal dialysate induce apoptosis through endoplasmic reticulum stress in peritoneal mesothelial cells.2012
Author(s)
Nakamata J, Morimoto H, Baba R, Ishimatsu N, Miyamoto T, Kanegae K, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M.
Organizer
49th ERA-EDTA (European Renal Association - European Dialysis and Transplant Association) Congress
Place of Presentation
Palais des Congres (Paris, France)
Related Report
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[Presentation] High glucose levels induce endoplasmic reticulum stress in peritoneal mesothelial cells2010
Author(s)
Nakamata J, Morimoto H, Baba R, Miyamoto T, Shibata T, Serino R, Kabashima N, Otsuji Y, Doi Y, Tamura M
Organizer
43rd Annual Meeting & Scientific Exposition (American Society of Nephrology, Renal week 2010)
Place of Presentation
Denver(USA)
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