| Project/Area Number |
22592061
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
OTA Masato 東京医科歯科大学, 大学院・医歯学総合研究科, 講師 (70313228)
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| Co-Investigator(Kenkyū-buntansha) |
KONDOH Takashi 独立行政法人理化学研究所, 免疫アレルキ゛ーセンター, 研究員 (40333299)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 味蕾幹細胞 / BrdU標識長期維持細胞 / 遺伝子群の検索 / Hes1 / Meis2 / 幹細胞ニッチ / 上皮特異的ノックアウトマウス / 徐法性ナノゲル |
|---|
| Research Abstract |
The epithelial stem cells that originally have been thought to make glands that secrete saliva and mucous membranes of the mouth. Here, we suggest that these stem cells also make cellsfeeling the taste in the mouth that locate around the tongue, back part of the upper jaw and throat. We observed that these cells have the very slow rate of cell growth and the expression ofseveral genes that is known ascharacteristic feature of the stem cells. Further, the cells of themucosa of the mouth with such genes was also suggested to play an important role as a stem cell to make the tooth roots.
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