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Regulation of mast cells by extracelluar matrix using self-organizing nano-technology method

Research Project

Project/Area Number 22592099
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pathobiological dentistry/Dental radiology
Research InstitutionTohoku Fukushi University

Principal Investigator

SUGIMOTO Koreaki  東北福祉大学, 総合福祉学部, 教授 (30361158)

Co-Investigator(Kenkyū-buntansha) TANAKA Masaru  山形大学, 理工学研究科, 教授 (00322850)
Project Period (FY) 2010-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords肥満細胞 / 炎症 / アレルギー / ヒスタミン / ナノテクノロジー / バイオマテリアル / 再生医療 / ナノバイオ / 再生医学
Research Abstract

We studied mast cell proliferation and regulation by honeycomb film (HCF). We used two types of mast cells, NCL-2 cell (new non-tumor mast cell line) and RBL-2H3 cell (rat basophilic leukemia cell line). Both of the cells cultured on 3, 5, and 10 micro m pore size of HCF revealed changing of proliferation rate, cell formation, and mediator release from mast cell though the quality of HCF is same. And then HCF regulation depended on the difference of a kind of cell. NCL-2 cell that is similar to human mucosal mast cell proliferated on the HCF, but reduced the release of TNF-alpha and leukotriene B4, which are de novo synthesized cytokines in mast cell.

Report

(5 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2014 2013 2012 2010

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (9 results)

  • [Journal Article] Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate but downregulate with multinucleated formation2014

    • Author(s)
      Hyunmi Choi, Masaru Tanaka, Takaaki Hiragun, Michihiro Hide, Koreaki Sugimoto
    • Journal Title

      Nanomedicine

      Volume: Vol.10 Issue: 2 Pages: 213-219

    • DOI

      10.1016/j.nano.2013.08.011

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Honeycomb-like structured film regulates mediator release from non-tumor mast cells2014

    • Author(s)
      Koreaki Sugimoto, Hyunmi Choi, Masaru Tanaka
    • Journal Title

      European Journal of Inflammation

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differences in cell proliferation and spontaneous mediator release between two mast cell lines (NCL-2 cells and RBL-2H3 cells) on honeycomb-like structured film2014

    • Author(s)
      Hyunmi Choi, Masaru Tanaka, Koreaki Sugimoto
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: (in press)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] ハニカムフイルム上で培養された非腫瘍性肥満細胞(NCL-2 cell)の多核化と機能低下について2014

    • Author(s)
      杉本是明,崔賢美,田中賢
    • Organizer
      日本薬理学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Year and Date
      2014-03-20
    • Related Report
      2013 Final Research Report
  • [Presentation] Non-tumor mast cells cultured in vitro on a honeycomb-like structured film proliferate but down-regulate with multinucleated formation2014

    • Author(s)
      杉本 是明、崔 賢美、田中 賢
    • Organizer
      日本薬理学会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 新規の自己増殖性正常肥満細胞(NCL-2 cell)のハニカム構造フィルム上での増殖と分裂2013

    • Author(s)
      崔賢美,田中賢,杉本是明
    • Organizer
      日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2013-03-21
    • Related Report
      2013 Final Research Report
  • [Presentation] 新規の自己増殖性正常肥満細胞(NCL-2 cell)のハニカム構造フィルム上での増殖と分裂2013

    • Author(s)
      崔 賢美、田中 賢、杉本 是明
    • Organizer
      日本再生医療学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Morphology and biochemical differences of mast cells (NCL-2 cells, RBL-2H3 cells) on the new extracellular matrix; Honeycomb Film2012

    • Author(s)
      K. Sugimoto, H. Choi, M. Tanaka, T. Hiragun, M. Hide
    • Organizer
      10^<th> International Society for Stem Cell Research
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2012-06-15
    • Related Report
      2013 Final Research Report
  • [Presentation] Morphology and biochemical differences of mast cells (NCL-2 cells, RBL-2H3 cells) on honeycomb-patterned polymer film2012

    • Author(s)
      H. Choi, M, K. Sugimoto
    • Organizer
      Asian Science Seminar 2012
    • Place of Presentation
      ソウル大学(韓国ソウル市)
    • Year and Date
      2012-02-14
    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Presentation] Morphology and biochemical differences of mast cells (NCL-2 cells, RBL-2H3 cells) on the new extracellular matrix; Honeycomb Film2012

    • Author(s)
      K. Sugimoto, H. Choi, M. Tanaka, T. Hiragun, M. Hide
    • Organizer
      10th International Society for Stem Cell Research
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Honeycomb filmを用いた肥満細胞の制御に関する予備的研究2010

    • Author(s)
      杉本是明
    • Organizer
      日本歯科心身医学会
    • Place of Presentation
      広島大学広仁会館(広島県広島市)
    • Year and Date
      2010-07-17
    • Related Report
      2013 Final Research Report
  • [Presentation] Honeycomb filmを用いた肥満細胞の制御に関する予備的研究2010

    • Author(s)
      杉本是明
    • Organizer
      日本歯科心身医学会
    • Place of Presentation
      広島大学広仁会館(広島市)
    • Year and Date
      2010-07-17
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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