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A development of the bonding treatment of vertically fractured roots with periodontal regeneration adhesive resin using tissue engineering

Research Project

Project/Area Number 22592108
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Conservative dentistry
Research InstitutionHokkaido University

Principal Investigator

TANAKA Saori  北海道大学, 北海道大学病院, 助教 (90344522)

Co-Investigator(Kenkyū-buntansha) SUGAYA Tsuomu  北海道大学, 大学院・歯学研究科, 准教授 (10211301)
MIYAJI Hirofumi  北海道大学, 北海道大学病院, 講師 (50372256)
Co-Investigator(Renkei-kenkyūsha) SHIMOJI Shinnji  北海道大学, 大学院・歯学研究科, 助教 (30431373)
YOSHIMURA Yoshitaka  北海道大学, 大学院・歯学研究科, 助教 (30230816)
TANAKA Toru  北海道大学, 北海道大学病院, 講師 (90179771)
Research Collaborator 加藤 昭人  北海道大学, 北海道大学病院, 医員
OTANI Kaori  北海道大学, 北海道大学病院, 医員
INOUE Kana  北海道大学, 大学院・歯学研究科, 医員
FUKUDA Hiroe  北海道大学, 大学院・歯学研究科, 大学院生
IBARA Asako  北海道大学, 大学院・歯学研究科, 大学院生
KANAYAMA Izumi  北海道大学, 大学院・歯学研究科, 大学院生
MOMOSE Takehito  北海道大学, 大学院・歯学研究科, 大学院生
NUSHIDA Erika  北海道大学, 大学院・歯学研究科, 大学院生
MIYATA Saori  北海道大学, 大学院・歯学研究科, 大学院生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords垂直歯根破折接着治療法 / 象牙質粉末含有接着性レジンセメント / β-TCP含有接着性レジンセメント / 培養細胞シート / 歯周組織再生 / rhBMP-2 / セメント質再生 / 象牙質含有レジン / BMP-2 / 接着性レジン / BMP-2 / 培養歯根膜シート / 4-META/MMA-TBB
Research Abstract

To enhance the bonding treatment of vertically fractured roots, we aimed to the newly cementum formation on a compound of resin and dentin powder, or β-TCP which may improve the binding between resin and cementum. In vitro, cytotoxicity was assessed. It had little cytotoxicity. In vivo, we observed the newly hard tissue formation on a resin containing β-TCP applied by rhBMP-2 and cultured bone marrow stromal cell sheets. This experiment might exhibit a possibility of the newly hard tissue formation on a resin.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2013 2012 2011 2010 Other

All Journal Article (8 results) (of which Peer Reviewed: 7 results) Presentation (13 results) Remarks (2 results)

  • [Journal Article] one Augmentation in Rat by Highly Porous β-TCP Scaffolds with Different Open-cell Sizes in Combination with Fibroblast Growth Factor-22013

    • Author(s)
      Hirofumi MIYAJI, Hiroyuki YOKOYAMA, Yuta KOSEN, Hiroyuki NISHIMURA, Kazuyasu NAKANE, Saori TANAKA, Kaori OTANI, Kana INOUE, Asako IBARA, Izumi KANAYAMA, Takashi YOSHIDA, Kosuke OGAWA, Erika NISHIDA and Masamitsu KAWANAMI
    • Journal Title

      J Oral Tissue Engin

      Volume: 10(3) Pages: 172-181

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bone augmentation in rat by highly porous β-TCP scaffolds with different open-cell sizes in combination with fibroblast growth factor-22013

    • Author(s)
      H Miyaji
    • Journal Title

      J Oral Tissue Engineering

      Volume: 10(3) Pages: 172-181

    • NAID

      130004941092

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Healing ofexperimental apical periodontitis after apicoectomy using different sealing materials on the resected root end2011

    • Author(s)
      Otani K, Sugaya T, Tomita M, Hasegawa Y, Miyaji H, Tenkumo T, Tanaka S, Motoki Y, Takanawa Y, Kawanami M
    • Journal Title

      Dent Mater J

      Volume: 30(4) Pages: 485-492

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Influence of root surface conditioning with bone morphogenetic protein-2 on periodontal wound healing in beagle dogs2011

    • Author(s)
      H Miyaji, T Sugaya, K Ibe, R Ishizuka, K Tokunaga, M Kawanami
    • Journal Title

      J Oral Tissue Engin

      Volume: 8 Pages: 173-180

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Healing of experimental apical periodontitis after apicoectomy using different sealing materials on the resected root end2011

    • Author(s)
      Otani K, ら
    • Journal Title

      Dent Mater J.

      Volume: 30 Pages: 485-492

    • NAID

      10029338707

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Periodontal healing by implantation of collagen hydrogel-sponge composite in one-wall infrabony defects in beagle dogs2010

    • Author(s)
      A Kato, H Miyaji, Y Kosen, H Yokoyama, R Ishizuka, K Tokunaga, K Inoue, M Henmi, S Tanaka, T Sugaya, M Kawanami
    • Journal Title

      J Oral Tissue Engin

      Volume: 8 Pages: 39-46

    • NAID

      130004941163

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 垂直破折歯根の接着治療とその診断,治療法の選択2010

    • Author(s)
      菅谷勉,田中佐織,元木洋史,川浪雅光,木村喜芳,野口裕史,加藤熈
    • Journal Title

      歯界展望

      Volume: 116(1) Pages: 52-59

    • Related Report
      2012 Final Research Report
  • [Journal Article] Periodontal healing by implantation of collagen hydrogel-sponge composi to in one-wall infrabony defects in beagle dogs.2010

    • Author(s)
      Kato Akihito
    • Journal Title

      Journal Oral Tissue Engineering

      Volume: 8(1) Pages: 39-46

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ナノβ-TCP/コラーゲンスャフォールドの作製と骨再生療法への応用2012

    • Author(s)
      井原朝子
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Final Research Report
  • [Presentation] The bone-forming effect of nano-β-TCP/collagen scaffold2012

    • Author(s)
      A Kato
    • Organizer
      98th annual meeting of AAP in collaboration with JSP
    • Place of Presentation
      Los Angeles Convention Center (USA)
    • Related Report
      2012 Final Research Report
  • [Presentation] 高気孔性β-TCPスキャフォールドの作製と評価2012

    • Author(s)
      宮治裕史
    • Organizer
      第55回春季日本歯周病学会学術大会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Related Report
      2012 Final Research Report
  • [Presentation] コンポジットレジンへのカーボンナノチューブコーティング技術の応用2012

    • Author(s)
      田中佐織
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノβ-TCP/コラーゲンスキャフォールドの作製と骨再生療法への応用.2012

    • Author(s)
      井原朝子
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] The bone-forming effect of nano-β-TCP/collagen scaffold.2012

    • Author(s)
      A KATO
    • Organizer
      98th annual meeting of AAP in collaboration with JSP
    • Place of Presentation
      Los Angeles Convention Center (USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ナノβ-TCP配合コラーゲンスキャフォールドの作製と評価2011

    • Author(s)
      井原朝子
    • Organizer
      第33回バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 高気孔性ナノβ-TCフォームへの作製と評価FGF2添加による骨新生効果2011

    • Author(s)
      宮治裕史, ら
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都府)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高気孔性β-TCPフォームへのFGF2添加による骨新生効果2011

    • Author(s)
      宮治裕史
    • Organizer
      第33回日本バイオマテリアル学会大会
    • Place of Presentation
      京都テルサ(京都)
    • Related Report
      2012 Final Research Report
  • [Presentation] 血液の汚染時間が4-META/MMA-TBBレジンと歯根象牙質の接着に及ぼす影響2010

    • Author(s)
      福田寛恵
    • Organizer
      第132回春季日本歯科保存学会
    • Place of Presentation
      崇城大学市民ホール(熊本県)
    • Year and Date
      2010-06-05
    • Related Report
      2012 Final Research Report
  • [Presentation] コンポジットレジンへのカーボンナノチューブコーティング技術の応用2010

    • Author(s)
      田中佐織
    • Organizer
      日本歯科保存学会2012年度秋季学術大会(第137回)
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Final Research Report
  • [Presentation] ゼラチンコーティングβ-TCPフォームの開発と骨再生療法への応用2010

    • Author(s)
      宮治裕史
    • Organizer
      第32回日本バイオマテリアル学会大会
    • Place of Presentation
      グランドプリンスホテル広島(広島県)
    • Related Report
      2012 Final Research Report
  • [Presentation] ゼラチンコーティングβ-TCPフォームの開発と骨再生療法への応用2010

    • Author(s)
      宮治裕史
    • Organizer
      第32回日本バイオマテリアル学会学術大会
    • Place of Presentation
      広島
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.den.hokudai.ac.jp/hozon2/perio.html

    • Related Report
      2012 Final Research Report
  • [Remarks] 研究紹介

    • URL

      http://www.den.hokudai.ac.jp/hozon2/perio.html

    • Related Report
      2012 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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