The effect of gradient FGF-2 on one-wall intrabony defect of periodontal tissue

• Project/Area Number: 22592182
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Osaka University
• Principal Investigator: SHIMABUKURO Yoshio 大阪大学, 大学院・歯学研究科, 招聘教員 (50231361)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849) ; HASHIKAWA Tomoko 大阪大学, 大学院・歯学研究科, 助教 (00362682)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
• Keywords: 再生歯学 / FGF-2 / 歯根膜細胞 / 細胞遊走 / PI3K / akt / ヒアルロン酸

Research Abstract

The present study showed that FGF-2 activated MPDL-22 proliferative reaction and cell migration and that the FGF-2-induced activity of cell migration was dependent on PI3K and akt pathway. Hyaluronan was also associated with the FGF-2-activated cell migration. FGF-2 enhanced the regenerative effect on periodontal tissue induced by ADSC

Research Products

• [Journal Article] Periodontal tissue regeneration by transplantation of adipose tissue-derived stem cells. (2013)
  • Author(s): Masahide Takedachi
  • Journal Title: Journal of Oral Bioscience Volume: in press
  • Peer Reviewed
• [Journal Article] Periodontal tissue regeneration by transplantation of adipose tissue-derived stem cells.
  • Author(s): _Masahide Takedachi_, Keigo Sawada,Satomi Yamamoto, Masao Ozasa, Yoshio Shimabukuro, Masahiro Kitamura, Shinya Murakami.
  • Journal Title: Journal of Oral Biosciences Volume: (in press)
• [Presentation] EVALUATION OF PERIODONTAL TISSUE REGENERATION BY TRANSPLANTATION OF ADIPOSE-TISSUE DERIVED STEM CELLS (2013)
  • Author(s): Keigo Sawada, Masahide Takedachi, Masao Ozasa, Tomoaki Iwayama, Takenori Nozaki,Takushi Tauchi, Koji Miki, Mitsuyoshi Iyama, Jun Anzai, Toshie Nagayasu, Akio
  • Organizer: The 6th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) 2nd Meeting of the International Association for Dental Research - Asia Pacific Region
  • Year and Date: 2013-04-13
• [Presentation] Evaluation of periodontal tissue regeneration by transplantation of adipose-tissue derived stem cells (2013)
  • Author(s): Keigo Sawada
  • Organizer: The 6th Pan Pacific Symposium on Stem cells and Cancer Research(PPSSC) 2nd Meeting of the International Association for Dental Research-Asia Pacific Region
  • Place of Presentation: Taiwan