Effects of LIPUS stimulation on the membraneous bone regeneration

• Project/Area Number: 22592198
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Dental engineering/Regenerative dentistry
• Research Institution: Nihon University
• Principal Investigator: ITO Koichi 日本大学, 歯学部, 教授 (90102607)
• Co-Investigator(Kenkyū-buntansha): SATO Shuichi 日本大学, 歯学部, 講師 (50225942)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: LIPUS / 骨 / 再生 / 移植・再生医療 / 低出力超音波刺激 / 膜性骨化 / 骨再生

Research Abstract

The effects of LIPUS stimulation on bone defect regeneration were examined in rat calvaria. Noncritical-sized circular defects were prepared in the parietal bone. LIPUS stimulation was performed and bone regeneration evaluated by micro CT and histological methods. LIPUS stimulation promotes bone regeneration in non-critical rat calvarial defects, and also in critical bone defects. Additionally,synergistic effect of LIPUS and GBR with titanium membrane could be expected.

Research Products

• [Journal Article] Autogenous bone with or without hydroxyapatite bone substitute augmentation in rat calvarium within a plastic cap. (2012)
  • Author(s): Oginuma T, Sato S, Udagawa A, Saito Y, Arai Y, Ito K
  • Journal Title: Oral Surg Oral Med Oral Pathol OralRadiol Volume: 114
  • Peer Reviewed
• [Journal Article] Correlation in the densities of augmented and existing bone in guided bone augmentation. (2012)
  • Author(s): Yamada Y, Sato S, Yagi H, Ujiie H, Ezawa T, Ito K
  • Journal Title: Clin Oral Implants Res Volume: 23 Pages: 837-845
  • Peer Reviewed
• [Journal Article] The potency of low-intensity pulsed ultrasound (LIPUS) in a rat calvarial guidedbone-regeneration model. (2011)
  • Author(s): Hasuike A, Sato S, Tsunori K, Ito K
  • Journal Title: J Hard Tissue Biol Volume: 20 Pages: 217-224
  • Peer Reviewed
• [Journal Article] In vivo bone regenerative effect of low-intensity pulsed ultrasound in rat calvarial defects. (2011)
  • Author(s): Hasuike A, Sato S, Udagawa A, Ando K, Arai A, Ito K
  • Journal Title: Oral Surg Oral Med OralPathol Oral Radiol Endod Volume: 111
  • Peer Reviewed
• [Journal Article] α-リン酸三カルシウムセメントにおける培養骨芽細胞様細胞の付着および浸潤率について. (2011)
  • Author(s): 福山富久,佐藤秀一,石橋和也,汐見登,菅井健二,深瀬康公,伊藤公一
  • Journal Title: 日大歯学 Volume: 85 Pages: 23-28
  • NAID: 10031146263
  • Peer Reviewed
• [Journal Article] In vivo bone regenerative effect of bone low-intesity pulsed ultrasound in rat calvarial defects (2011)
  • Author(s): Hasuike A
  • Journal Title: Oral Surg Oral Med Pathol Oral Radiol Endod Volume: 111
  • Peer Reviewed
• [Journal Article] A comparative study of micro-CT and the histomorphometry in evaluating bone augmentation in ratcalvarium. (2010)
  • Author(s): Kochi G, Sato S, Ebihara H, Hirano J, Arai Y, Ito K
  • Journal Title: J Oral Sci Volume: 52 Pages: 203-211
  • Peer Reviewed
• [Journal Article] Effects of ?-DT cement with hydroxypropylcellulose on bone augmentation within a titanium cap in the rabbit calvarium. (2010)
  • Author(s): Fukuyama T, Sato S, Fukase Y, Ito K
  • Journal Title: Dent Mater J Volume: 29 Pages: 160-166
  • Peer Reviewed
• [Presentation] Effects of bone marrow penetration rate and size on the guided bone augmentation in the rat calvarium. (2012)
  • Author(s): Sato S
  • Organizer: 98^<th> American Academy ofPeriodontology.
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2012-09-30
• [Presentation] 内側性骨欠損の血管新生に対するbFGFの効果. (2012)
  • Author(s): 木上理沙
  • Organizer: 第136回日本歯科保存学会学術大会
  • Place of Presentation: 沖縄
  • Year and Date: 2012-06-28
• [Presentation] bFGFによるラット内側性骨欠損における血管新生および骨再生のエックス線・組織学的検討. (2012)
  • Author(s): 木上理沙
  • Organizer: 第64回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-20
• [Presentation] PDGFがラット頭頂骨におよぼす影響 (2012)
  • Author(s): 土屋紀子
  • Organizer: 第64回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2012-05-20
• [Presentation] ラット頭頂骨における骨外側方向への骨増生に対するPDGFの影響 (2012)
  • Author(s): 土屋紀子
  • Organizer: 第55回春季日本歯周病学会学術大会
  • Place of Presentation: 北海道
  • Year and Date: 2012-05-20
• [Presentation] Effects of marrow penetration rate and size on the guided bone augmentarion in the rat calvarium (2012)
  • Author(s): Sato S
  • Organizer: American Academy of Periodontology
  • Place of Presentation: Los Angels (USA)
• [Presentation] Melatonin stimulates regeneration of bone in rat calvarial bone defects (2012)
  • Author(s): Hasuike A
  • Organizer: American Academy of Periodontology
  • Place of Presentation: Los Angels (USA)
• [Presentation] The potency of LIPUS in guided bone regeneratioa procedure (2011)
  • Author(s): Hasuike A
  • Organizer: 97^<th> American Academy of Periodontology
  • Place of Presentation: Flolida (USA)
  • Year and Date: 2011-11-20
• [Presentation] The potency of low-intensity pulsed ultrasound in guided bone regeneration procedure. (2011)
  • Author(s): Hasuike A
  • Organizer: 97^<th>American Academy of Periodontology
  • Place of Presentation: Florida, USA
  • Year and Date: 2011-11-12
• [Presentation] ラクトフェリンの内側生骨欠損における骨再生の効果 (2011)
  • Author(s): 吉巻友裕
  • Organizer: 第54回秋季日本歯周病学会学術大会
  • Place of Presentation: 山口
  • Year and Date: 2011-09-30
• [Presentation] Effect of bone marrow penetration on the guided bone augmentation in the rat calvarium: comparative study of micro-CT and histomorphometry. (2010)
  • Author(s): Sato S
  • Organizer: 96^<th>American Academy of Periodontology
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-10-30
• [Presentation] The adhesion and infiltration of cultured osteoblast-like cells within α-DT and β-TCP. (2010)
  • Author(s): Fukuyama T
  • Organizer: 96^<th>American Academy of Periodontology
  • Place of Presentation: Honolulu, USA
  • Year and Date: 2010-10-30
• [Presentation] 低出力超音波パルス刺激のラット頭頂骨内側性骨欠損に対する骨再生促進効果の検討. (2010)
  • Author(s): 蓮池聡
  • Organizer: 第62回日本大学歯学会総会学術大会
  • Place of Presentation: 東京
  • Year and Date: 2010-05-30
• [Presentation] ラットGBAモデルを用いた自家骨と骨補填材の併用による骨外側方向への骨増生の影響. (2010)
  • Author(s): 荻沼毅
  • Organizer: 第53回春季日本歯周病学会学術大会
  • Place of Presentation: 岩手
  • Year and Date: 2010-05-15
• [Presentation] 低出力超音波パルス刺激のラット頭頂骨内側性骨欠損に対する骨再生促進効果 (2010)
  • Author(s): 蓮池聡, 佐藤秀一, 伊藤公一
  • Organizer: 日本大学歯学会
  • Place of Presentation: 日本大学歯学部(東京都)
  • Year and Date: 2010-05-15
• [Presentation] 骨外側方向への骨増生法に関する研究 (2010)
  • Author(s): 佐藤秀一
  • Organizer: 第33回臨床応用を目指した3次元臓器造形研究会
  • Place of Presentation: 東京
  • Year and Date: 2010-01-30