Development of titanium implants after alkali heating treatment with a [Zn(OH)_4]^2- complex to promote osteoblast proliferation and differentiation
| Project/Area Number |
22592205
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Akita University |
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Principal Investigator |
FUKUDA Masayuki 秋田大学, 医学部, 准教授(病院教授) (20272049)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Osamu 山形大学, 大学院・理工学研究科, 教授 (00230540)
TAKANO Hiroshi 秋田大学, 医学部, 助教 (30282172)
NAKATA Akira 秋田大学, 医学部, 助教 (50400510)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | チタン系インプラント / 亜鉛修飾 / 骨芽細胞 / 分化・増殖 |
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| Research Abstract |
Titanium implants chemically-modified with a solution containing [Zn(OH)_4]^2- complex (Zn-Ti) were fabricated and assessed the effect of promoting osteoblast proliferation and differentiation. Zn-Ti released Zn^2+ ions and these ions promoted osteoblast proliferation, differentiation and calcium deposition around the Zn-Ti. Zn-Ti demonstrated significantly stronger bone fixation than non-modified implants at all healing times.
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Report
(4 results)
Research Products
(39 results)
