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Basic research on regeneration medicine to cleft lip and/or palate patients using human mesenchymal stem cells.

Research Project

Project/Area Number 22592223
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionSaga University

Principal Investigator

YAMASHITA Yoshio  佐賀大学, 医学部, 准教授 (50322300)

Co-Investigator(Kenkyū-buntansha) GOTO Masaaki  佐賀大学, 医学部, 教授 (10145211)
NOGUCHI Nobuhiro  佐賀大学, 医学部, 講師 (40284658)
DANJO Atsushi  佐賀大学, 医学部, 助教 (80452712)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords再生医学 / 間葉系幹細胞 / 口唇口蓋裂 / 再生医療 / 成長因子
Research Abstract

We discovered the tiny population of undifferentiated cells in surgical specimens from patients with cleft lip and/or palate. They have potential to promote the regeneration. They can differentiate into osteoblasts, adipocyte and chondrocyte, like as bone marrow stem cells and dental pulp stem cells. Our data demonstrate that the mesenchymal stem cells may provide therapeutic benefits for treating cleft lip and/or palate patients. Stem cell based therapy holds great promise for establishing such a multifaceted therapeutic strategy.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (14 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Comprehensive analysis of bacterial flora in postoperative maxillary cyst fluid by 16SrRNA gene and culture methods.2012

    • Author(s)
      Sano N, Yamashita Y, Fukuda K, Taniguchi H, Goto M, Miyamoto H.
    • Journal Title

      International Scholarly Research Network (ISRN)

      Volume: Vol.2012 Pages: 1-11

    • DOI

      10.5402/2012/840483

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomical measurement of the depth and location of the sublingual fossa.2012

    • Author(s)
      Uchida Y, Goto M, Danjo A, Yamashita Y, Kuraoka Y.
    • Journal Title

      International Journal of Oral and Maxillofacial Surgery

      Volume: Vol.41 Issue: 12 Pages: 1571-1576

    • DOI

      10.1016/j.ijom.2012.03.015

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 酸素ラジカルを用いた低温プラズマ滅菌装置の滅菌特性と歯科用バーに対する滅菌性能2012

    • Author(s)
      山下佳雄、木戸淳太、後藤昌昭、林 信哉
    • Journal Title

      日本口腔科学会雑誌

      Volume: Vol.61(1) Pages: 16-23

    • NAID

      10030795639

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 顎口腔領域における静脈奇形に対するオレイン酸モノエタノールアミンを用いた硬化療法2012

    • Author(s)
      檀上 敦、山下佳雄、森 啓輔、野口信宏、下平大治、後藤昌昭
    • Journal Title

      日本口腔科学会雑誌

      Volume: Vol.61(3) Pages: 243-250

    • NAID

      10031144855

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 顎裂骨移植部へのデンタルインプラントの使用2011

    • Author(s)
      山下佳雄、黒田好美、後藤昌昭
    • Journal Title

      日本口蓋裂学会雑誌

      Volume: Vol.36(1) Pages: 26-32

    • NAID

      10030794923

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 下顎骨再建に用いた移植骨へ埋入したインプラント周囲骨の経時的変化2011

    • Author(s)
      山下佳雄、森 啓輔、重松正仁、檀上 敦、野口信宏、後藤昌昭
    • Journal Title

      日本顎顔面インプラント学会誌

      Volume: Vol.10 Pages: 63-68

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A long-term comparative study of two rigid internal fixation techniques in terms of masticatory function and neurosensory disturbance after mandibular correction by bilateral sagittal split ramus osteotomy2011

    • Author(s)
      Yamashita Y., Otsuka T., Shigematsu M., Goto M
    • Journal Title

      Int J Oral Maxillofac Surg

      Volume: Vol.40 Pages: 360-365

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a novel PCR method to comprehensively analyze salivary bacterial flora and its application to patients with odontogenic infections2010

    • Author(s)
      Akiyama T, Miyamoto H, Fukuda K, Sano N, Katagiri N, Shobuike T, Kukita A, Yamashita Y, Taniguchi H, Goto M.
    • Journal Title

      Oral Surg Oral Med Oral Pathol Oral Radiol Endod

      Volume: 109 Pages: 669-676

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epithelial-myoepithelial carcinoma of a minor salivary gland of the intrabuccal mucosa : A case report.2010

    • Author(s)
      Yamashita Y., Murata K, Goto M.
    • Journal Title

      Asian J Oral Maxillofac Surg.

      Volume: 22 Pages: 88-90

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A long-term comparative study of two rigid internal fixation techniques in terms of masticatory function and neurosensory disturbance after mandibular correction by bilateral sagittal split ramus osteotomy.2010

    • Author(s)
      Yamashita Y., Otsuka T., Shigematsu M., Goto M
    • Journal Title

      Int J Oral Maxillofac Surg.

      Volume: (未定(In press))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 口唇口蓋裂患者の一貫治療 多種職とのチームアプローチ2012

    • Author(s)
      山下佳雄
    • Organizer
      第23回西日本臨床小児口腔外科学会(招待講演)
    • Place of Presentation
      山口
    • Year and Date
      2012-10-07
    • Related Report
      2012 Final Research Report
  • [Presentation] 顎骨再建症例に対するインプラント治療2012

    • Author(s)
      山下佳雄
    • Organizer
      第17回日本顎顔面インプラント学会教育研修会(招待講演)
    • Place of Presentation
      東京
    • Year and Date
      2012-08-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 唇顎口蓋裂患者における間葉系幹細胞を用いた再生医療の確立2012

    • Author(s)
      山下佳雄
    • Organizer
      第36回日本口蓋裂学会 シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2012-05-29
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「腫瘍切除後に用いられたインプラント治療の弱点」2011

    • Author(s)
      山下佳雄
    • Organizer
      第15回日本顎顔面インプラント学会学術大会
    • Place of Presentation
      千葉
    • Year and Date
      2011-12-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] インプラント医学の社会的貢献唇顎口蓋裂患者に対する応用とその注意点2011

    • Author(s)
      山下佳雄
    • Organizer
      第41回日本口腔インプラント学会 シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム「インプラント医学の社会的貢献-唇顎口蓋裂患者に対する応用とその注意点」2011

    • Author(s)
      山下佳雄
    • Organizer
      第41回日本口腔インプラント学会学術大会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 下顎枝矢状分割術後の咀嚼機能ならびに下唇知覚障害の経時的変化(スクリュー固定とプレート固定の比較)2011

    • Author(s)
      山下佳雄
    • Organizer
      第21回日本顎変形症学会総会・30周年記念国際シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2011-06-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 間葉系幹細胞による口腔内組織再生のための研究2011

    • Author(s)
      山下佳雄
    • Organizer
      第65回日本口腔科学会(宿題報告)
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2012 Final Research Report
  • [Presentation] 宿題報告「間葉系幹細胞による口腔内組織再生のための研究」2011

    • Author(s)
      山下佳雄
    • Organizer
      第65回日本口腔科学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] 高齢患者の腫瘍切除後に使用した下顎再建用プレートの有効性の検討2011

    • Author(s)
      山下佳雄
    • Organizer
      第29回日本口腔腫瘍学会総会・学術大会
    • Place of Presentation
      熊本
    • Year and Date
      2011-01-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] A long-term comparative study of two rigid internal fixation techniques in terms of masticatory function and neurosensory disturbance after mandibular correction by bilateral sagittal split ramus osteotomy2010

    • Author(s)
      Yamashita, Y., Danjo, A., Noguchi, N., Goto, M
    • Organizer
      The 9th Asian Congress on Oral & Maxillofacial Surgery
    • Place of Presentation
      Kuala Lumpur
    • Related Report
      2010 Annual Research Report
  • [Presentation] シンポジウム「唇顎口蓋裂患者における間葉系幹細胞を用いた再生医療の確立」

    • Author(s)
      山下佳雄
    • Organizer
      第36回日本口蓋裂学会総会・学術集会
    • Place of Presentation
      京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 顎骨再建症例に対するインプラント治療

    • Author(s)
      山下佳雄
    • Organizer
      第17回日本顎顔面インプラント学会教育研修会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 口唇口蓋裂患者の一貫治療  多種職とのチームアプローチ

    • Author(s)
      山下佳雄
    • Organizer
      第23回西日本臨床小児口腔外科学会
    • Place of Presentation
      y山口
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] 口腔外科最新レビュー「インプラント義歯の歴史と概要」口腔外科ハンドマニュアル'10 口腔外科YEAR BOOK2010

    • Author(s)
      後藤昌昭、山下佳雄
    • Publisher
      クインテッセンス出版
    • Related Report
      2012 Final Research Report
  • [Book] 口腔外科ハンドマニュアル'102010

    • Author(s)
      後藤昌昭, 山下佳雄
    • Publisher
      クインテッセンス出版(東京)
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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