Regeneration of salivary gland by autologous cell transplantation

• Project/Area Number: 22592224
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: HIRAKI Akimitsu 熊本大学, 大学院・生命科学研究部, 講師 (60404034)
• Co-Investigator(Kenkyū-buntansha): SHINOHARA Masanori 熊本大学, 大学院・生命科学研究部, 教授 (90117127)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 唾液腺 / 再生・医学 / 細胞・組織 / 発生・分化 / 唾液腺細胞 / 分化 / 再生/医学

Research Abstract

We isolated monoclonal mouse epithelial salivary gland cells by original medium. By usingthe cells, we identified important factor associated differentiation induction ofbidimensionally. Moreover we tried regeneration of the gland three-dimensionally. As aresult, they indicated that HGF and type IV collagen play an important role in 3Dregeneration of the salivary gland. To reveal its mechanism, we need further study

Research Products

• [Journal Article] Histopathological Changes in Parotidand Submandibular Glands of PatientsTreated with Preoperative ChemoradiationTherapy for Oral Cancer (2012)
  • Author(s): Keiko TESHIMA, Ryuji MURAKAMI, RyojiYOSHIDA, Hideki NAKAYAMA, Akimitsu HIRAKI,Toshinori HIRAI, Yuji NAKAGUCHI, NaokoTSUJITA, Etsushi TOMITAKA, MitsuhiroFURUSAWA, Yasuyuki YAMASHITA, MasanoriSHINOHARA
  • Journal Title: Journal of Radiation Research Volume: 53(3) Pages: 492-496
  • Peer Reviewed
• [Journal Article] Histopathological Changes in Parotid and Submandibular Glands of Patients Treated with Preoperative Chemoradiation Therapy for Oral Cancer (2012)
  • Author(s): Keiko Teshima1, Ryuji Murakami, RyojiYoshida, Hideki Nakayama, AkimitsuHiraki, Toshinori Hirai, Yuji Nakaguchi,Naoko Tsujita, Etsushi Tomitaka,Mitsuhiro Furusawa, Yasuyuki Yamashita,Masanori Shinohara
  • Journal Title: Journal of Radiation Research Volume: 53 Issue: 3 Pages: 492-496
  • DOI: 10.1269/jrr.11115
  • NAID: 130001876862
  • ISSN: 0449-3060, 1349-9157
  • Peer Reviewed
• [Presentation] 口腔癌の化学放射線療法における唾液変化と口腔粘膜炎に関する検討 (2013)
  • Author(s): 竹下尚志、吉田遼司、平木昭光、高尾直宏、川原健太、中川純泰、永田将士、田中拓也、中山秀樹、篠原正徳
  • Organizer: 第31回日本口腔腫瘍学会総会
  • Place of Presentation: 秋葉原コンベンションホール東京
• [Presentation] 唾液腺腫瘍 98 例の臨床統計的検討 (2013)
  • Author(s): 吉田遼司、平木昭光、中山秀樹、丸瀬靖之、永田将士、田中拓也、川原健太、中川純泰、廣末晃之、吉武義泰、太田和俊、篠原正徳
  • Organizer: 第31回日本口腔腫瘍学会総会
  • Place of Presentation: 秋葉原コンベンションホール東京
• [Presentation] 口腔癌の化学放射線療法における唾液変化と口腔粘膜炎に関する検討 (2013)
  • Author(s): 竹下尚志
  • Organizer: 第31回日本口腔腫瘍学会総会
  • Place of Presentation: 秋葉原コンベンションホール、東京