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Analysis of microRNA in temporomandibular joint inflammation

Research Project

Project/Area Number 22592230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Surgical dentistry
Research InstitutionNihon University

Principal Investigator

KONDOH Toshirou  日本大学, 松戸歯学部, 教授 (70178416)

Co-Investigator(Kenkyū-buntansha) OGURA Naomi  日本大学, 松戸歯学部, 講師 (10152448)
AKUTSU Miwa  日本大学, 松戸歯学部, 助教 (10523524)
ITO Ko  日本大学, 松戸歯学部, 助教 (20419758)
Research Collaborator KAWASHIMA Mutsumi  日本大学, 松戸歯学部, 大学院生
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords顎関節 / 滑膜炎 / 滑膜細胞 / microRNA / マイクロアレイ解析 / interluekin-1β / tumor necrosis factor-α / 顎関節内障 / 顎関節滑膜細胞 / mRNA / microRNA標的遺伝子 / IL-1beta / TNF-arpha / interleukin-1 / tumor necrosis factor / TargetScan / microRNA標的遺伝
Research Abstract

MicroRNA (miRNA) are a class of small non-coding RNAs that mediate the post-transcriptional regulation of target mRNA expression. miRNA are associated with pathologic conditions. We have investigated of IL-1β or TNF-α-responsive miRNA and mRNA in synoviocytes for putative genes associated with the synovitis using microarray analysis. The target genes for IL-1β? and/or TNF-α?responsive miRNA were searched by the databases such as TargetScan. The expressions of the target genes were analyzed by DNA microarray. The knowledge of miRNA-miRNA studies would help to understand the pathologic conditions in TMJ.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (19 results)

All 2013 2012 2011 2010 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (14 results) (of which Invited: 3 results)

  • [Journal Article] The anti-inflammatory effect of cyclooxygenase inhibitors in fibroblast-like synoviocytes from the human temporomandibular joint results from the suppression of PGE2 production.2013

    • Author(s)
      Kawashima M, Ogura N, Akutsu M, Ito K, Kondoh T.
    • Journal Title

      J Oral Pathol Med.

      Volume: (in press) Issue: 6 Pages: 499-506

    • DOI

      10.1111/jop.12045

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of interleukin-1β and tumor necrosis factor-α on macrophage inflammatory protein-3α production in synovial fibroblast-like cells from human temporomandibular joints.2013

    • Author(s)
      Akutsu M, Ogura N, Ito K, Kawashima M, Kishida T, Kondoh T.
    • Journal Title

      J Oral Pathol Med.

      Volume: (in press) Issue: 6 Pages: 491-498

    • DOI

      10.1111/jop.12040

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Comparative analysis of MicroRNA-mRNA expression profiles of mesenchymal stem cells and dental follicle cells.2012

    • Author(s)
      Ogura N, Takahashi K, Iwai S, Fujimoto Y, Hashimoto H, Kondoh T.
    • Journal Title

      In J Oral-Med Sci

      Volume: 11(1) Pages: 13-21

    • NAID

      130002051678

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] IL-1βおよびTNF-α刺激ヒト顎関節滑膜細胞におけるIL-6 cytokine familyの発現2012

    • Author(s)
      河島 睦
    • Journal Title

      日本顎関節学会雑誌

      Volume: 24 Pages: 91-99

    • NAID

      130001921911

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-1βおよびTNF-α刺激ヒト顎関節滑膜細胞におけるIL-6cytokine familyの発現

    • Author(s)
      河島睦,小倉直美,阿久津美和,伊藤耕,近藤壽郎
    • Journal Title

      日本顎関節学会雑誌

      Volume: 24巻2号 Pages: 91-99

    • NAID

      130001921911

    • URL

      http://www.jstage.jst.go.jp/browse/gakukansetsu/-char/ja/

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Predictive factors of temporomandibular joint disease in synovial tissues and fluid---A microarray analysis of synovial cells and a literature sesarch on synovial fluid analysis---.2012

    • Author(s)
      Toshirou Kondoh.
    • Organizer
      International Conference on TMJ Biology, Diagnosis and Surgical Management.
    • Place of Presentation
      University Medical CenterGroningen (Groningen, Netherland)
    • Year and Date
      2012-10-05
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-1β刺激滑膜細胞におけるCOX阻害薬の効果2012

    • Author(s)
      河島睦他4名
    • Organizer
      日本顎関節学会
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(札幌)
    • Year and Date
      2012-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-1β刺激ヒト顎関節滑膜細胞におけるmicroRNAおよびmRNA発現解析2012

    • Author(s)
      河島睦他4名
    • Organizer
      日本口腔科学会
    • Place of Presentation
      広島国際会議場(広島)
    • Year and Date
      2012-05-18
    • Related Report
      2012 Final Research Report
  • [Presentation] IL-1β刺激ヒト顎関節滑膜細胞におけるmicroRNAおよびmRNA発現解析2012

    • Author(s)
      河島 睦
    • Organizer
      日本口腔科学会
    • Place of Presentation
      広島国際会議場(広島)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-1β刺激滑膜細胞へのCOX阻害薬添加の影響2012

    • Author(s)
      河島 睦
    • Organizer
      日本歯科薬物療法学会
    • Place of Presentation
      大阪国際会議場(大阪)
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL-1β刺激滑膜細胞におけるCOX阻害薬の効果2012

    • Author(s)
      河島 睦
    • Organizer
      日本顎関節学会
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(札幌)
    • Related Report
      2012 Annual Research Report
  • [Presentation] TNF-α刺激ヒト顎関節滑膜細胞におけるmicroRNA発現解析2011

    • Author(s)
      小倉直美他4名
    • Organizer
      日本顎関節学会
    • Place of Presentation
      広島県民分化センター(広島)
    • Year and Date
      2011-07-23
    • Related Report
      2012 Final Research Report
  • [Presentation] TNF-α刺激ヒト顎関節滑膜細胞におけるmicroRNA発現解析2011

    • Author(s)
      小倉直美
    • Organizer
      日本顎関節学会
    • Place of Presentation
      広島県民文化センター
    • Year and Date
      2011-07-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] IL-1βおよびTNF-α刺激による培養ヒト顎関節滑膜細胞のケモカイン産生と遺伝子発現2010

    • Author(s)
      河島睦, 他
    • Organizer
      第55回社団法人日本口腔外科学会学術大会
    • Place of Presentation
      幕張メッセ(千葉県)
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] IL-1β誘発滑膜炎におけるM-CSF発現2010

    • Author(s)
      伊藤耕他4名
    • Organizer
      日本顎関節学会
    • Place of Presentation
      タワーホール船堀(東京)
    • Year and Date
      2010-07-24
    • Related Report
      2012 Final Research Report
  • [Presentation] Predictive factors of temporomandibular joint disease in synovial tissues and fluid---A microarray analysis of synovial cells and a literature search on synovial fluid analysis

    • Author(s)
      Toshirou Kondoh
    • Organizer
      International Conference on TMJ Biology, Diagnosis and Surgical management
    • Place of Presentation
      University Medical Center Groningen (オランダ,フローニンゲン)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 顎関節滑膜細胞におけるCOX阻害薬の抗炎症作用

    • Author(s)
      河島 睦
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 顎関節疾患への低侵襲手術と拡大手術

    • Author(s)
      近藤壽郎
    • Organizer
      日本口腔外科学会
    • Place of Presentation
      パシフィコ横浜(横浜)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] in vitro滑膜炎モデルから顎関節を考える

    • Author(s)
      近藤壽郎
    • Organizer
      日本顎関節学会
    • Place of Presentation
      シャトレーゼガトーキングダムサッポロ(札幌)
    • Related Report
      2012 Annual Research Report
    • Invited

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Published: 2010-08-23   Modified: 2019-07-29  

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