Original approach to obtain intrinsic resistance genes to cisplatin

• Project/Area Number: 22592237
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Hokkaido University
• Principal Investigator: OHIRO Yoichi 北海道大学, 大学院・歯学研究科, 講師 (40301915)
• Co-Investigator(Kenkyū-buntansha): TOTSUKA Yasunori 北海道大学, 名誉教授 (00109456) ; KITAMURA Tetsuya 北海道大学, 大学院・歯学研究科, 助教 (00451451) ; SHINDOH Masanobu 北海道大学, 大学院・歯学研究科, 教授 (20162802)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 抗癌剤耐性 / 口腔がん / シスプラチン / 耐性遺伝子 / 口腔癌

Research Abstract

This study investigated the relationship between cisplatin resistance and osteopontin which is candidate gene responsible for drug resistance. Oral squamous cell carcinoma cells transfected with osteopontin were increased in resistance to cisplatin treatment and in activity of AKT. Knockdown of osteopontin chemosensitized cancer cells to cisplatin. The resistance mechanism of osteopontin was depend on AKT activation. These results suggest that osteopontin expression in oral cancer could be a useful predictable marker for the response to cisplatin.

Research Products

• [Journal Article] Expression of parathyroid hormone-related protein confers malignant potential to mucoepidermoid carcinoma (2013)
  • Author(s): Nagamine K, KitamuraT
  • Journal Title: Oncol Rep Volume: 29(6) Issue: 6 Pages: 2114-8
  • DOI: 10.3892/or.2013.2393
  • Peer Reviewed
• [Journal Article] 最新の歯学;口腔癌治療における術前化学療法併用放射線治療の現状 (2013)
  • Author(s): 大廣洋一,栗林和代,足利雄一,小野貢伸,鄭漢忠,北村哲也,進藤正信
  • Journal Title: 北海道歯学会雑誌 Volume: 33(2) Pages: 192-195
• [Journal Article] 口腔癌治療における術前化学療法併用放射線治療の現状 (2013)
  • Author(s): 大廣 洋一
  • Journal Title: 北海道歯学雑誌 Volume: 33 Pages: 192-195
  • NAID: 10031165925
• [Journal Article] オステオポンチンは内因性シスプラチン耐性遺伝子で，抗がん剤治療のターゲットとなりうる． (2013)
  • Author(s): 柏尾啓太
  • Journal Title: 北海道歯学雑誌 Volume: 33 Pages: 103-110
  • Peer Reviewed
• [Journal Article] 口腔癌におけるPTP4A1のシスプラチン内因性耐性メカニズム． (2013)
  • Author(s): 岡田知之
  • Journal Title: 北海道歯学雑誌 Volume: 33 Pages: 111-120
  • Peer Reviewed
• [Journal Article] 多発性肺転移を伴った巨大な下顎エナメル上皮癌の1例 (2012)
  • Author(s): 佐藤(栗林)和代,小野貢伸,足利雄一,大廣洋一
  • Journal Title: 日口外誌 Volume: 58(3) Pages: 137-141
  • NAID: 10031144872
  • Peer Reviewed
• [Journal Article] E1A expression might becontrol led by miR- 214incells with low adenovirus productivity (2012)
  • Author(s): Yanagawa-Matsuda A, KitamuraT, 他4名
  • Journal Title: VirusRes Volume: 170(1-2) Issue: 1-2 Pages: 85-90
  • DOI: 10.1016/j.virusres.2012.09.001
  • Peer Reviewed
• [Journal Article] Viral - mediated sta bilization of AU - rich element containing mRNA contributes to cell transformation (2011)
  • Author(s): Kuroshima T , Aoyagi M , Yasuda M , Kitamura T,他6名
  • Journal Title: Oncogene Volume: 30(26) Issue: 26 Pages: 2912-20
  • DOI: 10.1038/onc.2011.14
  • Peer Reviewed
• [Presentation] Histopathological response of concurrent preoperative chemoradiotherapy with Docetaxel and Cisplatin for Oral Squamous Cell Carcinoma. (2012)
  • Author(s): Ohiro Y
  • Organizer: Congress of The European Association for Cranio-Maxillofacial Surgery
  • Place of Presentation: Valamar
• [Presentation] 口腔扁平上皮癌に対する術前化学放射線療法の治療効果について (2012)
  • Author(s): 栗林（佐藤）和代
  • Organizer: 第５７回日本口腔外科学会総会・学術大会
  • Place of Presentation: パシフィコ横浜（横浜）
• [Presentation] Histopathological response of concurrent preoperative chemoradiotherapy with Docetaxel and Cisplatin for Oral Squamous Cell Carcinoma (2012)
  • Author(s): Ohiro，Y.
  • Organizer: 21th European Association for Cranio-Maxillo-Facial Surgery
  • Place of Presentation: Valamar Lacroma Dubrovnik Hotel（Croatia）
• [Presentation] THE PATTERN OF RESIDUAL TUMORS AFTER CONCURRENT CHEMORADIOTHERAPY IN ADVANCED LOWER GINGIVAL CARCINOMA (2010)
  • Author(s): 大廣洋一
  • Organizer: 第9回アジア口腔外科学会
  • Place of Presentation: KUALA LUMPUR,マレーシア
  • Year and Date: 2010-11-26