Establishment of the new diagnostic procedure of oral cancer whichtargeted midkine and development of the therapy

• Project/Area Number: 22592240
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Kumamoto University
• Principal Investigator: OTA Kazutoshi 熊本大学, 医学部附属病院, 講師 (20336209)
• Co-Investigator(Kenkyū-buntansha): SHINOHARA Masanori 熊本大学, 生命科学研究部, 教授 (90117127) ; ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742) ; 植田 光晴 熊本大学, 大学院・生命科学研究部, 助教 (60452885)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 臨床腫瘍学 / ミッドカイン / 口腔癌 / 腫瘍マーカー / 薬剤耐性 / 網羅的解析法

Research Abstract

We demonstrated that serum midkine concentrations were a usefulmarker of oral squamous cell carcinoma (OSCC), because midkine protein overexpressed inOSCC tissues and blood of OSCC patients. Furthermore, we showed that the increased S-MKconcentrations in OSCC patients were strongly associated with poor survival. We suggestedthat mechanism by which for midkine inhibited a cell cycle and promoted angiogenesis wasinvolved in anticancer drug resistance. The drug-resistant change by the midkineexpression suppression may be a novel treatment strategy of the cancer therapy.

Research Products

• [Journal Article] Therapeutic approaches targetingmidkine suppress tumor growth and lungmetastasis in osteosarcoma (2012)
  • Author(s): Sueyoshi T, Jono H, Shinriki S, Ota K,Ota T, Tasaki M, Atsuyama E, YakushijiT, Ueda M, Obayashi K, Mizuta H, AndoY
  • Journal Title: CancerLett Volume: 316(1) Pages: 23-30
  • Peer Reviewed
• [Journal Article] Downregulation of midkineinduces cisplatin resistance in humanoral squamous cell carcinoma (2012)
  • Author(s): Ota T, Jono H, Ota K, Shinriki S, UedaM, Sueyoshi T, Nakatani K, Hiraishi Y,Wada T, Fujita S, Obayashi K, ShinoharaM, Ando Y
  • Journal Title: OncolRep Volume: 27(5) Pages: 1674-1680
  • Peer Reviewed
• [Journal Article] Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma. (2012)
  • Author(s): Takanao Sueyoshi, Hirofumi Jono, Satoru Shinriki, Kazutoshi Ota, Tomoko Ota, Masayoshi Tasaki, Eri Atsuyama, Toshitake Yakushiji, Mitsuharu Ueda, Konen Obayashi, Hiroshi Mizuta, Yukio Ando
  • Journal Title: Cancer Letter Volume: Volume 316, Issue 1 Issue: 1 Pages: 23-30
  • DOI: 10.1016/j.canlet.2011.10.013
  • NAID: 120004419579
  • Peer Reviewed
• [Journal Article] Long-term survival after liver transplantation in patients with familial amyloid polyneuropathy (2012)
  • Author(s): Yamashita T
  • Journal Title: Neurology Volume: 78 Pages: 637-43
  • DOI: 10.3892/or.2012.1684
  • Peer Reviewed
• [Journal Article] Interleukin-6 signallingregulates vascular endothelial growthfactor-C synthesis andlymphangiogenesis in human oralsquamous cell carcinoma (2011)
  • Author(s): Shinriki S, Jono H, Ueda M, Ota K, OtaT, Sueyoshi T, Oike Y, Ibusuki M,Hiraki A, Nakayama H, Shinohara M, AndoY
  • Journal Title: J Pathol Volume: 225(1) Pages: 142-50
  • Peer Reviewed
• [Journal Article] (2010)
  • Author(s): Ota K, Fujimori H, Ueda M, Jono H,Shinriki S, Ota T, Sueyoshi T, Taura M,Taguma A, Kai H, Shinohara M, AndoY
  • Journal Title: Int J Oncol Volume: 37(4) Pages: 797-804
  • Peer Reviewed
• [Journal Article] Midkine expression inmalignant salivary gland tumors andits role in tumor angiogenesis (2010)
  • Author(s): Ota T, Ota K, Jono H, Fujimori H, UedaM,Shinriki S, Sueyoshi T, Shinohara M,Ando Y
  • Journal Title: OralOncol Volume: 46(9) Pages: 657-61
  • Peer Reviewed
• [Journal Article] Midkine expression is correlated with an adverse prognosis and is down-regulated by p53 in oral squamous cell carcinoma. (2010)
  • Author(s): Kazutoshi Ota, Hiromi Fujimori, Mitsuharu Ueda, Hirofumi Jono, Satoru Shinriki, Tomoko Ota, Tak anao Sueyoshi, Manabu Taura, Ayaka Taguma, Hirofumi Kai, Masanori Shinohara, Yukio Ando
  • Journal Title: International Journal of Oncology Volume: 37 Pages: 797-804
  • Peer Reviewed
• [Journal Article] Midkine expression in malignant salivary gland tumors and its role in tumor angiogenesis (2010)
  • Author(s): Tomoko Ota, Kazutoshi Ota, Hiro fumi Jono, Hiromi Fujimori, Mitsuharu Ueda, Satoru Shinriki, Takanao Sueyoshi, Masanori Shinohara, Yukio, Ando
  • Journal Title: Oral Oncology Volume: 46 Pages: 657-671
  • NAID: 120003184564
  • Peer Reviewed
• [Presentation] Overexpression of the novel oncogeneSALL4 in oral squamous cell carcinoma (2013)
  • Author(s): Ota K, Ueda M, Shinriki S, Yoshida R,Yasunaga M, Shinohara M, AndoY
  • Organizer: 27th ICMFS World Congress
  • Place of Presentation: Bad Hofgastein, Austria
  • Year and Date: 2013-05-06
• [Presentation] 口腔扁平上皮癌における Zinc finger 蛋白 Sall4 発現についての検討 (2011)
  • Author(s): 太田和俊、 吉田遼司、 植田光晴、 神力 悟、太田智子、末吉貴直、城野博史、安東由喜 男、 篠原正徳
  • Organizer: 第49回日本癌治療学会学術集会
  • Place of Presentation: 名古屋国際会議場 名古屋 ポスター
  • Year and Date: 2011-10-28
• [Presentation] 唾液腺腫瘍におけるミッドカイン発現の検討 (2011)
  • Author(s): 太田智子、太田和俊、神力悟、城野博史、安東由喜雄、篠原正徳
  • Organizer: 第65回NPO法人日本口腔科学会学術集会
  • Place of Presentation: タワーホール船堀東京
  • Year and Date: 2011-04-21