| Project/Area Number |
22592240
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Kumamoto University |
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Principal Investigator |
OTA Kazutoshi 熊本大学, 医学部附属病院, 講師 (20336209)
|
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| Co-Investigator(Kenkyū-buntansha) |
SHINOHARA Masanori 熊本大学, 生命科学研究部, 教授 (90117127)
ANDO Yukio 熊本大学, 生命科学研究部, 教授 (20253742)
植田 光晴 熊本大学, 大学院・生命科学研究部, 助教 (60452885)
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 臨床腫瘍学 / ミッドカイン / 口腔癌 / 腫瘍マーカー / 薬剤耐性 / 網羅的解析法 |
|---|
| Research Abstract |
We demonstrated that serum midkine concentrations were a usefulmarker of oral squamous cell carcinoma (OSCC), because midkine protein overexpressed inOSCC tissues and blood of OSCC patients. Furthermore, we showed that the increased S-MKconcentrations in OSCC patients were strongly associated with poor survival. We suggestedthat mechanism by which for midkine inhibited a cell cycle and promoted angiogenesis wasinvolved in anticancer drug resistance. The drug-resistant change by the midkineexpression suppression may be a novel treatment strategy of the cancer therapy.
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