Establishment of dendritic cell-based vaccine in combination with chemotherapy for oral cancer patients
| Project/Area Number |
22592247
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Keio University (2011-2012)
Musashino University (2010) |
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Principal Investigator |
OKAMOTO Masato 慶應義塾大学, 医学部, 特任准教授 (10243718)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔癌 / 免疫療法 / 癌ワクチン / 樹状細胞 / 化学療法剤 / 免疫化学療法 / がん免疫療法 / S-1 / docetaxel / がんワクチン / 細胞障害性T細胞 / 制御性T細胞 / Th1サイトカイン / 化学放射線療法 |
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| Research Abstract |
We have reported that dendritic cell (DC)-based vaccine is effective in oral cancer patients. Certain chemotherapeutic agents may enhance antitumor effect of cancer vaccine mediated by improvement of immunological condition in cancer patients. In the curr
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Report
(4 results)
Research Products
(101 results)
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[Journal Article] Immuno-Chemoradiotherapy for Patients with Oral Squamous Cell Carcinoma: Augmentation of OK-432-Induced Helper T-Cell 1 Response by 5-FU and X-Ray Irradiation2013
Author(s)
Tano T, Okamoto M, Kan S, Bando T, Goda H, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Sato M, Yamashita N, Hamakawa H, Kawakami Y
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Journal Title
Neoplasia
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Fusion cells generated with dendritic cells and whole tumors2013
Author(s)
Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Uchiyama K, Kajihara M,Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.
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Journal Title
OncoImmunol
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Combined TLR2/4-activated dendritic/tumor cell fusions induce augmented cytotoxic T lymphocytes2013
Author(s)
Koido S, Homma S, Okamoto M, Namiki Y, Takakura K, Takahara A, Odahara S, Tsukinaga S, Yukawa T, Motobe J, Kajihara M, Matsudaira H, Nagatsuma K, Uchiyama K, Arihiro S, Imazu H, Arakawa H, Kan S, Komita H, Ito M, Ohkusa T, Gong J, Tajiri H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Prognostic impact of expression of Bcl-2 and Bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Shimodaira S, Koido S, Homma S, Sato M, Fujita T, Kawakami Y, Hamakawa H
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Journal Title
Neoplasia
Volume: 15(3)
Pages: 305-314
Related Report
Peer Reviewed
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[Journal Article] Eur J Cancer2013
Author(s)
Hidenori Takahashi
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Journal Title
10.1016/j.ejca.2012.11.005
Volume: 49
Issue: 4
Pages: 852-859
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical and immunologic evaluation of dendritic cell-based immunotherapy in combination with gemcitabine and/or S-1 in the patients with advanced pancreatic carcinoma2012
Author(s)
Kimura Y, Tsukada J, Tomoda T, Takahashi H, Imai K, Shimamura K, Sunamura M, Yonemitsu Y, Shimodaira S, Koido S, Homma S, Okamoto M
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Journal Title
Pancreas
Volume: 41(2)
Pages: 195-205
Related Report
Peer Reviewed
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[Journal Article] Selective inhibition of NF-kB suppresses bone invasion by oral squamous cell carcinoma in vivo2012
Author(s)
Furuta H, Osawa K, Shin M, Ishikawa A, Matsuo K, Khan M, Aoki K, Ohya K, Okamoto M, Tominaga K, Takahashi T, Nakanishi O, Jimi E
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Journal Title
International Journal of Cancer
Volume: (in press)
Issue: 5
DOI
Related Report
Peer Reviewed
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