| Project/Area Number |
22592258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
MAEDA Shigeru 岡山大学, 岡山大学病院, 准教授 (50253000)
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| Co-Investigator(Kenkyū-buntansha) |
MIYAWAKI Takuya 岡山大学, 大学院・医歯薬学総合研究科, 教授 (00219825)
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| Research Collaborator |
HIGUCHI Hitoshi 岡山大学, 岡山大学病院, 講師 (30423320)
TOMOYASU Yumiko 岡山大学, 大学院・・医歯薬学総合研究科, 助教 (40594809)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 炎症 / ストレス反応 / HPA axis / 視床下部 / CRH / 糖質コルチコイド / 副腎皮質ステロイド / 視床下部室傍核 / LPS / 歯科 |
|---|
| Research Abstract |
Depression can be induced by an activation of stress reaction related with infection, injury, etc. Since oral area is a favorite site for inflammation, affect of oral inflammation on both inflammatory reaction and stress reaction, was evaluated in this study. As a result, stress reaction was induced in oral inflammatory model, and it is suggested that stress related with inflammation may be controlled by an opioid.
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