| Project/Area Number |
22592259
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
|
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TOMIOKA Shigemasa 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (70188770)
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| Co-Investigator(Kenkyū-buntansha) |
SATOMURA Kazuhito 鶴見大学, 歯学部, 教授 (80243715)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 再生 / 末梢神経 / 麻酔薬 / 骨髄間質細胞 / 分化誘導 |
|---|
| Research Abstract |
We differentiated murine bone marrow stromal cells (BMSCs) into Schwann cells in vitro. We suggests that BMSCs needs ascorbic acids and glutamic acids in the culture condition of differentiation into Schwann cells. We also examined the effects of general anesthetics and a local anesthetic onSchwann cells derived from BMSCs, which results suggest that a general anesthetic, propofol and a local anesthetic, lidocaine had the inhibitory effects on Schwann cells derived from BMSCs.
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