• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Analysis of biological function of recombinase A in Streptococcus mutansquorum sensing

Research Project

Project/Area Number 22592283
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthodontic/Pediatric dentistry
Research InstitutionOsaka University

Principal Investigator

INAGAKI Satoko  大阪大学, 歯学部附属病院, 医員 (50527223)

Co-Investigator(Kenkyū-buntansha) OOSHIMA Takashi  大阪大学, 歯学研究科, 招聘教員 (80116003)
NAKANO Michiyo  岡山大学, 医歯薬学総合研究科, 教授 (30359848)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsStreptococcus mutans / リコンビナーゼA / クオラムセンシング / バイオフィルム / Recombinase A / Glucosyltransferase / リコンビネーション / 耐酸性 / 臨床分離株 / う蝕 / グルコシルトランスフェラーゼ
Research Abstract

Streptococcus mutansproduces 3 types of glucosyltransferases (GTFs), whose cooperative action is essential for cellular adhesion, with the recombinase A (RecA) protein required for homologous recombination. Determination of the sequences of the gtfBand gtfCgenes showed that an approximately 3500-bp region was deleted in the smooth colonies of S. mutans. These results suggest that DNA recombination and phenotypic changes that occur through uptake of extracellular RecA may have a relationship with the signal transduction system involving biofilm formation in S. mutans.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (14 results)

All 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (8 results) Remarks (2 results)

  • [Journal Article] Regulation of recombination between gtfB/gtfCgenes inStreptococcus mutansby recombinase A2013

    • Author(s)
      Inagaki S, Fujita K, Takashima Y, Nagayama K, Ardin AC, Matsumi Y, Matsumoto-Nakano M
    • Journal Title

      Sci World J

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of Recombination between gtfB/gtfC Genes in Streptococcus mutans by Recombinase A.2013

    • Author(s)
      Inagaki S, Fujita K, Takashima Y, Nagayama K, Ardin AC, Matsumi Y, Matsumoto-Nakano M.
    • Journal Title

      The Scientific World Journal

      Volume: 2013 Issue: 1 Pages: 405075-405075

    • DOI

      10.1155/2013/405075

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of Oenothera biennis (Evening Primrose) seed extract on Streptococcus mutans and S.mutans-induced dental caries in rats.2011

    • Author(s)
      Matsumoto-Nakano, et al.
    • Journal Title

      Caries Research

      Volume: 45 Pages: 56-63

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of biological properties With glucan-binding protein B expression profile in Streptococus mutans clinical isolates.2011

    • Author(s)
      Fujita K, Takashima Y, et al.
    • Journal Title

      Archives of Oral Biology

      Volume: 56 Pages: 258-263

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Streptococcus mutans のRec Aタンパクによるgtf遺伝子発現制御について2012

    • Author(s)
      稲垣暁子、松本道代、大嶋 隆
    • Organizer
      第50回 日本小児歯科学会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2012 Annual Research Report
  • [Presentation] 日本小児歯科学会奨励賞受賞講演:バイオフィルム形成におけるStreptococcus mutans recA遺伝子の機能解析2011

    • Author(s)
      稲垣暁子
    • Organizer
      第49回日本小児歯科学会大会
    • Place of Presentation
      岩手県盛岡市(招待講演)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Contribution of Recombinase A of Streptococcus mutans to glucosyltransferase activity2011

    • Author(s)
      InaBaki S, Matsumoto-Nakano M, et al.
    • Organizer
      89th IADR meeting
    • Place of Presentation
      SanDiego, USA
    • Year and Date
      2011-03-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] Contribution of recombinase A of Streptococcus mutansto glucosyltransferase activity2011

    • Author(s)
      Inagaki S, Nakano M, Fujita K, Nagayama K, Takashima Y, Ooshima T
    • Organizer
      89th General Session of International Association of Dental Research
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2011-03-16
    • Related Report
      2012 Final Research Report
  • [Presentation] Streptococcus mutansRecA タンパクのグルカン合成酵素の活性に及ぼす影響2010

    • Author(s)
      稲垣暁子,松本道代,藤田一世,永山佳代子,高島由紀子,大嶋 隆
    • Organizer
      平成 22 年度日本小児歯科学会秋季大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] Streptococcus mutans RecAタンパクのグルカン合成酵素の活性に及ぼす影響2010

    • Author(s)
      稲垣暁子、松本道代、藤田一世、永山佳代子、高島由紀子、大嶋隆
    • Organizer
      平成22年度日本小児歯科学会秋季大会
    • Place of Presentation
      郡山
    • Year and Date
      2010-12-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] Contribution of RecA protein to GTF activity of Streptococcus mutans2010

    • Author(s)
      Inagaki S, Matsumoto-Nakano M, Fujita K, Nagayama K, Takashima Y, Ooshima T
    • Organizer
      88th General Session of International Association of Dental Research
    • Place of Presentation
      Barcelona (Spain)
    • Year and Date
      2010-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Contribution of RecA protein to GTF activity of Streptococcus mutans2010

    • Author(s)
      InaBak i S, Matsumoto-Nakano M, et al.
    • Organizer
      88th IADR meeting
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://web.dent.osaka-u.ac.jp/~pedo/research/index.html

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://web.dent.osaka-u.ac.jp/~pedo/research/index.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi