| Project/Area Number |
22592283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
|
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| Research Institution | Osaka University |
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Principal Investigator |
INAGAKI Satoko 大阪大学, 歯学部附属病院, 医員 (50527223)
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| Co-Investigator(Kenkyū-buntansha) |
OOSHIMA Takashi 大阪大学, 歯学研究科, 招聘教員 (80116003)
NAKANO Michiyo 岡山大学, 医歯薬学総合研究科, 教授 (30359848)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Streptococcus mutans / リコンビナーゼA / クオラムセンシング / バイオフィルム / Recombinase A / Glucosyltransferase / リコンビネーション / 耐酸性 / 臨床分離株 / う蝕 / グルコシルトランスフェラーゼ |
|---|
| Research Abstract |
Streptococcus mutansproduces 3 types of glucosyltransferases (GTFs), whose cooperative action is essential for cellular adhesion, with the recombinase A (RecA) protein required for homologous recombination. Determination of the sequences of the gtfBand gtfCgenes showed that an approximately 3500-bp region was deleted in the smooth colonies of S. mutans. These results suggest that DNA recombination and phenotypic changes that occur through uptake of extracellular RecA may have a relationship with the signal transduction system involving biofilm formation in S. mutans.
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