| Project/Area Number |
22592285
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TANIMOTO Kotaro 広島大学, 病院, 講師 (20322240)
TANNE Kazuo 広島大学, 医歯薬保健学研究院, 教授 (30159032)
INUBUSHI Toshihiro 広島大学, 医歯薬保健学研究院, 助教 (30550941)
TANNE Yuki 広島大学, 医歯薬保健学研究院, 助教 (50526241)
KAMIYA Takashi 広島大学, 医歯薬, 特任助教 (40551057)
OHKUMO Satoshi 広島大学, 病院, 歯科診療医 (20564389)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 歯科矯正学 |
|---|
| Research Abstract |
In vitro, substrate production of aggrecan was enhanced by LIPUS stimulation, and it became clear to 3 MHz that frequency is the most effective in substrate production of cartilage matrix by chondrocyte. In the cartilage tissue of the temporomandibular joint under the inflammatory condition, it was shown that LIPUS stimulation effectively suppressed the expression of COX-2. Furthermore, in vivo, the LIPUS stimulation to a mandibular condyle in OA model rats did not affect the histological change of OA, however, under the inflammatory condition, it was shown that effective suppression progress of OA by enhancing production of a cartilage matrix.
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