Development of infection prophylaxis bymucus-relatedgene control

• Project/Area Number: 22592333
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Hiroshima University
• Principal Investigator: TSURUDA Keiko 広島大学, 大学院・医歯薬保健学研究院, 助教 (10112210)
• Co-Investigator(Kenkyū-buntansha): SUGAI Motoyuki 広島大学, 大学院・医歯薬保健学研究院, 教授 (10201568)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 予防歯科学 / MUC1遺伝子 / 口腔粘膜 / CDT / 細胞致死抑制

Research Abstract

In this study, we focus on the MUC1 gene involved in mucus which has the ability of infection resistance. The aim of this study is to clarify the relationship between MUC1 and the ability of defending against infection. MUC1 gene was transfected to mammalian cells, and we examined the ability to defend against bacterial infection in the cells with MUC1 expression.