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Effects of probiotics in human evolutional model

Research Project

Project/Area Number 22592350
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Social dentistry
Research InstitutionTsurumi University

Principal Investigator

OKAMOTO Masaaki  鶴見大学, 歯学部, 講師 (30116008)

Co-Investigator(Kenkyū-buntansha) HANADA Nobuhiro  鶴見大学, 歯学部, 教授 (70180916)
NOMURA Yoshiaki  鶴見大学, 歯学部, 准教授 (90350587)
Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords人類進化モデル / 歯学 / 微生物 / 社会医学 / 進化 / 口腔細菌叢 / チンパンジー / ピロシーケンス / プロバイオテックス / 寿命 / 次世代シーケンサー / 新菌種 / 口腔衛生状態
Research Abstract

We have been analyzing the oral flora in chimpanzee by the pyrosequencing method, and found the major family was Veillonellaceae, which was different from human oral flora. We have also found a novel mutans streptococci in chimpanzee oral cavities, and named as “Streptococcus troglodytae”, which was different kind of indigenous streptococci isolated from human and monkey. These results suggest that the investigation of chimpanzee oral cavities may contribute human oral health, because the oral flora has been evolved with the host evolution.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (21 results)

All 2013 2012 2011 2010 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results) Presentation (16 results) Remarks (1 results)

  • [Journal Article] Distributionof Streptococcus troglodytae and Streptococcus dentirousetti in chim- panzee oral cavities.2013

    • Author(s)
      Miyanohara M, Imai S, Okamoto M, Saito W, Nomura Y, Momoi Y, Tomonaga M, Hanada N.
    • Journal Title

      Microbiology and Immunology, in press

      Volume: [Epub ahead of print] Issue: 5 Pages: 359-65

    • DOI

      10.1111/1348-0421.12047

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of Streptococcus troglodytae and Streptococcus dentirousetti in chimpanzee oral cavities.2013

    • Author(s)
      Miyanohara M
    • Journal Title

      Microbiol Immunol

      Volume: 57 Pages: n/a-n/a

    • DOI

      10.1111/j.1348-0421.12047

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Streptococcus troglodytae sp.nov., from the Chimpanzee Oral Cavity2012

    • Author(s)
      Okamoto M, Imai S, Miyanohara M, Saito W, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-Nishiwaki T, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M, Hanada N
    • Journal Title

      Int J Syst Evol Microbiol

      Volume: (Epub ahead of print) Issue: Pt_2 Pages: 418-22

    • DOI

      10.1099/ijs.0.039388-0

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Opportunistic respiratory pathogens in oral cavity of elderly2010

    • Author(s)
      Tada A, Hanada N
    • Journal Title

      FEMS Immunol.Med.Microbiolo.

      Volume: 60(1) Pages: 1-17

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] チンパンジー口腔内から分離されたStreptococcus mutans様菌株について2012

    • Author(s)
      岡本公彰、今井奬、花田信弘
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎県、長崎ブリックホール
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] A Novel Mutans Streptococci isolated from Chimpanzee Oral Cavity2012

    • Author(s)
      Okamoto M, Imai S, Miyanohara M, Saito W, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-NishiwakiT, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M and Hanada N.
    • Organizer
      The sixth International Association for Dental Research Pan-European Region Meeting (IADR/PER).
    • Place of Presentation
      Helsinki, Finland.
    • Related Report
      2012 Final Research Report
  • [Presentation] Distribution of Streptococci in Oral Flora of Chimpanzee2012

    • Author(s)
      Imai S, Okamoto M, Miyanohara M, SaitoW, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-NishiwakiT, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M and Hanada N.
    • Organizer
      The sixth International Association for Dental Research Pan-European Region Meeting (IADR/ PER).
    • Place of Presentation
      Helsinki, Finland.
    • Related Report
      2012 Final Research Report
  • [Presentation] チンパンジ ー 口腔内から分離されたstreptococcus mutans様菌株について2012

    • Author(s)
      岡本公彰、今井 奬、花田信弘
    • Organizer
      第85回 日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール
    • Related Report
      2012 Final Research Report
  • [Presentation] A Novel Mutans Streptococci isolated from Chimpanzee Oral Cavity2012

    • Author(s)
      Okamoto M
    • Organizer
      The sixth International Association for Dental Research Pan-European Region Meeting (IADR/PER)
    • Place of Presentation
      Helsinki, Finland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distribution of Streptococci in Oral Flora of Chimpanzee2012

    • Author(s)
      Imai S
    • Organizer
      The sixth International Association for Dental Research Pan-European Region Meeting (IADR/PER)
    • Place of Presentation
      Helsink, Finland
    • Related Report
      2012 Annual Research Report
  • [Presentation] Preliminary Analysis of Oral Flora isolated from Chimpanzee2011

    • Author(s)
      Okamoto M., et al
    • Organizer
      XIII, International Congress of Bacteriology and Applied Microbiology
    • Place of Presentation
      北海道、札幌コンベンションセンター
    • Year and Date
      2011-09-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Pyrosequencing Analysis of Oral Flora isolated from Chimpanzees2011

    • Author(s)
      Okamoto M., et al
    • Organizer
      45th Meeting of the CED-IADR
    • Place of Presentation
      ハンガリー、ブダペスト
    • Year and Date
      2011-09-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] チンパンジー口腔由来のミュー タンス レンサ 球菌 様細菌 に関す る研 究2011

    • Author(s)
      阿保備子,宮之原真由,今井奬,岡本公彰,齋藤渉,山口貴央,井川知子,小川 匠,野村義明,宮部貴子,桃井保子,花 田信弘
    • Organizer
      鶴見大学歯学会第73回例会
    • Place of Presentation
      鶴見大学会館メインホール
    • Year and Date
      2011-06-25
    • Related Report
      2012 Final Research Report
  • [Presentation] チンパンジー口腔由来のレンサ球 菌の性状に関する研究2011

    • Author(s)
      宮之原真由,今井奬,齋藤渉,山口貴央,阿保備子,野村義明,桃井保子,花田信 弘
    • Organizer
      第60回日本口腔衛生学会
    • Place of Presentation
      日本大学松戸歯学部
    • Related Report
      2012 Final Research Report
  • [Presentation] Preliminary Analysis of Oral Flora isolated from Chimpanze XIII2011

    • Author(s)
      Okamoto M, Miyanohara M, Abo T, Saito W, Ogawa T, Momoi Y, Sakamoto M., Ohkuma M, Miyabe-Nishiwaki, T and Hanada N.
    • Organizer
      International Congress of Bacteri- ology and Applied Microbiology (国際細菌学会).
    • Place of Presentation
      札幌
    • Related Report
      2012 Final Research Report
  • [Presentation] Pyrosequencing Analysis of Oral Flora isolated from Chim- panzees.2011

    • Author(s)
      Okamoto M, Miyanohara M, Abo T, ImaiS, Nomura Y, Saito W, Ogawa T, Momoi Y, Sakamoto M, Ohkuma M, Watanabe S, Maeda N, Watanabe A, Kaneko A, Miyabe- Nishiwaki T, Tomonaga M and Hanada N
    • Organizer
      The 45th Meeting of the Continental European Division of the International Asso- ciation for Dental Research the(CED- IADR)
    • Place of Presentation
      Budapest, Hungary.
    • Related Report
      2012 Final Research Report
  • [Presentation] チン パンジー歯垢より単離したレンサ球菌の性状に関する研究2010

    • Author(s)
      宮之原真由,今井奨,齋藤渉,山口貴央,小川匠,井川知子,岡本公彰,阿保備子, 野村義明,西村剛,宮部貴子,藤澤道子, 友永雅己,桃井保子,花田信弘
    • Organizer
      鶴見大学歯学会第72回例会
    • Place of Presentation
      鶴見大学会館 メインホール
    • Year and Date
      2010-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] チンパンジーの口腔内 および顎顔面領域の定期健診ならびに歯 科処置について2010

    • Author(s)
      小川匠,井川知子,齋藤渉,今井奬,野 村義明,岡本公彰,桃井保子,花田信弘, 兼子明久,渡辺朗野,渡辺祥平,宮部貴 子,友永雅己
    • Organizer
      鶴見大学歯学会第72回例会
    • Place of Presentation
      鶴見大学会館メインホール
    • Year and Date
      2010-12-18
    • Related Report
      2012 Final Research Report
  • [Presentation] Oral Status of Chimpanzees in Primate Research Institute Kyoto University.2010

    • Author(s)
      Momoi Y, Saito W, Ogawa T, IkawaT, Nomura Y, Imai S, Hanada N, Miyabe T, Watanabe A, Kanaeko A, Watanabe S, and Tomonaga T.
    • Organizer
      58thAnnual Meeting of the JADR(国際歯科研究学会日本部会), Kitakyusyu, Japan.
    • Place of Presentation
      Kyusyu DentalCollege.
    • Related Report
      2012 Final Research Report
  • [Presentation] Oral Status of Chimpanzees in Primate Research Institute Kyoto University2010

    • Author(s)
      Momoi Y., et al.
    • Organizer
      58th Annual Meeting of JADR
    • Place of Presentation
      九州歯科大学
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.pri.kyoto-u.ac.jp/pub/ronbun/0353.html

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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