Effects of probiotics in human evolutional model

2012 Fiscal Year Final Research Report

• Project/Area Number: 22592350
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Social dentistry
• Research Institution: Tsurumi University
• Principal Investigator: OKAMOTO Masaaki 鶴見大学, 歯学部, 講師 (30116008)
• Co-Investigator(Kenkyū-buntansha): HANADA Nobuhiro 鶴見大学, 歯学部, 教授 (70180916) ; NOMURA Yoshiaki 鶴見大学, 歯学部, 准教授 (90350587)
• Project Period (FY): 2010 – 2012
• Keywords: 人類進化モデル / 歯学 / 微生物 / 社会医学 / 進化

Research Abstract

We have been analyzing the oral flora in chimpanzee by the pyrosequencing method, and found the major family was Veillonellaceae, which was different from human oral flora. We have also found a novel mutans streptococci in chimpanzee oral cavities, and named as “Streptococcus troglodytae”, which was different kind of indigenous streptococci isolated from human and monkey. These results suggest that the investigation of chimpanzee oral cavities may contribute human oral health, because the oral flora has been evolved with the host evolution.

Research Products

• [Journal Article] Distributionof Streptococcus troglodytae and Streptococcus dentirousetti in chim- panzee oral cavities. (2013)
  • Author(s): Miyanohara M, Imai S, Okamoto M, Saito W, Nomura Y, Momoi Y, Tomonaga M, Hanada N.
  • Volume: [Epub ahead of print]
  • Pages: 1348-0421.12047.
  • DOI: doi:10.1111/1348-0421.12047.
  • Peer Reviewed
• [Journal Article] Streptococcus troglodytae sp. nov., from the chimpanzee oral cavity. (2013)
  • Author(s): Okamoto M, Imai S, Miyanohara M, Saito W, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-Nishiwaki T, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M, Hanada N.
  • Journal Title: Int. J Syst Evol Microbiol. Volume: 63 Pages: 418-22
  • DOI: doi:10.1099/ijs.0.039388-0
  • Peer Reviewed
• [Presentation] A Novel Mutans Streptococci isolated from Chimpanzee Oral Cavity (2012)
  • Author(s): Okamoto M, Imai S, Miyanohara M, Saito W, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-NishiwakiT, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M and Hanada N.
  • Organizer: The sixth International Association for Dental Research Pan-European Region Meeting (IADR/PER).
  • Place of Presentation: Helsinki, Finland.
  • Year and Date: 20120912-0915
• [Presentation] Distribution of Streptococci in Oral Flora of Chimpanzee (2012)
  • Author(s): Imai S, Okamoto M, Miyanohara M, SaitoW, Momoi Y, Abo T, Nomura Y, Ikawa T, Ogawa T, Miyabe-NishiwakiT, Kaneko A, Watanabe A, Watanabe S, Hayashi M, Tomonaga M and Hanada N.
  • Organizer: The sixth International Association for Dental Research Pan-European Region Meeting (IADR/ PER).
  • Place of Presentation: Helsinki, Finland.
  • Year and Date: 20120912-0915
• [Presentation] チンパンジ ー 口腔内から分離されたstreptococcus mutans様菌株について (2012)
  • Author(s): 岡本公彰、今井 奬、花田信弘
  • Organizer: 第85回 日本細菌学会総会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 20120327-0329
• [Presentation] チンパンジー口腔由来のレンサ球 菌の性状に関する研究 (2011)
  • Author(s): 宮之原真由,今井奬,齋藤渉,山口貴央,阿保備子,野村義明,桃井保子,花田信 弘
  • Organizer: 第60回日本口腔衛生学会
  • Place of Presentation: 日本大学松戸歯学部
  • Year and Date: 20111008-1010
• [Presentation] Preliminary Analysis of Oral Flora isolated from Chimpanze XIII (2011)
  • Author(s): Okamoto M, Miyanohara M, Abo T, Saito W, Ogawa T, Momoi Y, Sakamoto M., Ohkuma M, Miyabe-Nishiwaki, T and Hanada N.
  • Organizer: International Congress of Bacteri- ology and Applied Microbiology (国際細菌学会).
  • Place of Presentation: 札幌
  • Year and Date: 20110906-0910
• [Presentation] Pyrosequencing Analysis of Oral Flora isolated from Chim- panzees. (2011)
  • Author(s): Okamoto M, Miyanohara M, Abo T, ImaiS, Nomura Y, Saito W, Ogawa T, Momoi Y, Sakamoto M, Ohkuma M, Watanabe S, Maeda N, Watanabe A, Kaneko A, Miyabe- Nishiwaki T, Tomonaga M and Hanada N
  • Organizer: The 45th Meeting of the Continental European Division of the International Asso- ciation for Dental Research the(CED- IADR)
  • Place of Presentation: Budapest, Hungary.
  • Year and Date: 20110831-0903
• [Presentation] チンパンジー口腔由来のミュー タンス レンサ 球菌 様細菌 に関す る研 究 (2011)
  • Author(s): 阿保備子,宮之原真由,今井奬,岡本公彰,齋藤渉,山口貴央,井川知子,小川 匠,野村義明,宮部貴子,桃井保子,花 田信弘
  • Organizer: 鶴見大学歯学会第73回例会
  • Place of Presentation: 鶴見大学会館メインホール
  • Year and Date: 2011-06-25
• [Presentation] Oral Status of Chimpanzees in Primate Research Institute Kyoto University. (2010)
  • Author(s): Momoi Y, Saito W, Ogawa T, IkawaT, Nomura Y, Imai S, Hanada N, Miyabe T, Watanabe A, Kanaeko A, Watanabe S, and Tomonaga T.
  • Organizer: 58thAnnual Meeting of the JADR(国際歯科研究学会日本部会), Kitakyusyu, Japan.
  • Place of Presentation: Kyusyu DentalCollege.
  • Year and Date: 20101120-1121
• [Presentation] チン パンジー歯垢より単離したレンサ球菌の性状に関する研究 (2010)
  • Author(s): 宮之原真由,今井奨,齋藤渉,山口貴央,小川匠,井川知子,岡本公彰,阿保備子, 野村義明,西村剛,宮部貴子,藤澤道子, 友永雅己,桃井保子,花田信弘
  • Organizer: 鶴見大学歯学会第72回例会
  • Place of Presentation: 鶴見大学会館 メインホール
  • Year and Date: 2010-12-18
• [Presentation] チンパンジーの口腔内 および顎顔面領域の定期健診ならびに歯 科処置について (2010)
  • Author(s): 小川匠,井川知子,齋藤渉,今井奬,野 村義明,岡本公彰,桃井保子,花田信弘, 兼子明久,渡辺朗野,渡辺祥平,宮部貴 子,友永雅己
  • Organizer: 鶴見大学歯学会第72回例会
  • Place of Presentation: 鶴見大学会館メインホール
  • Year and Date: 2010-12-18