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A new pain-related protein kinase signal transduction map: an analysis by phosphor proteomics

Research Project

Project/Area Number 22600001
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 疼痛学
Research InstitutionKagoshima University

Principal Investigator

KURIHARA Takashi  鹿児島大学, 大学院・医歯学総合研究科, 准教授 (60282745)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords痛み / プロテオーム / シグナル伝達 / 脊髄 / リン酸化酵素 / ホールセルパッチクランプ / 後根神経節 / ホールセルパッチクランプ記録 / カゼインキナーゼ1 / CK1阻害薬 / 酵素 / 脳・神経
Research Abstract

We have suggested that CK1δ/ε play important physiological roles in both neuropathic and inflammatory pain signaling, which makes them useful targets for analgesic drug development. We have also identified several potential new CK1 inhibitors. TG003, one of these candidates, was suggested to have potent inhibitory effects on CK1 isoforms in vitro, and showed antinociceptive effects on acute and persistent inflammatory pain models in mice. Our data indicate that TG003 might be a promising lead compound for the development of CK1-targeted new analgesic drugs .

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (45 results)

All 2013 2012 2011 2010 2009 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (39 results) Remarks (4 results)

  • [Journal Article] Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells.2012

    • Author(s)
      Miura, A., Odahara, N., Tominaga, A., Inoue, K., Kambe, Y., Kurihara, T. & Miyata, A.
    • Journal Title

      FEBS Lett.

      Volume: 586 Issue: 12 Pages: 1731-1735

    • DOI

      10.1016/j.febslet.2012.05.009

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009

    • Author(s)
      Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S & Tanabe, T
    • Journal Title

      Mol. Pain

      Volume: 5 Pages: 74-74

    • DOI

      10.1186/1744-8069-5-74

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] マウス炎症性疼痛および神経障害性疼痛モデルにおける遊離脂肪酸受容体GPR40作動薬の効果2013

    • Author(s)
      カルキ・プラサンナ、朝田俊秀、吉村惠、有田和徳、宮田篤郎、栗原崇
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] PAC1遺伝子の負の発現調節にトランスグルタミナーゼ2によるSp1の不活性化が関与する2013

    • Author(s)
      三浦綾子、神戸悠輝、井上和彦、栗原崇、辰川英樹、小嶋聡一、宮田篤郎
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Cタイプナトリウム利尿ペプチドは、血液脳関門の透過性制御に関与する2013

    • Author(s)
      宮田篤郎、ボハラマノズ、神戸悠輝、栗原崇、時村洋、有田和徳
    • Organizer
      第86回日本薬理学会年会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 炎症性疼痛モデルマウスに対する新規カゼインキナーゼ阻害薬の抗侵害効果2012

    • Author(s)
      川元大輔、喜井勲、豊本雅靖、朝田俊秀、吉村惠、萩原正敏、宮田篤郎、栗原崇
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Year and Date
      2012-11-23
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
  • [Presentation] On the role of casein kinase 1 in mouse models of inflammatory and neuropathic pain2012

    • Author(s)
      Kurihara, T., Sakurai, E., Asada, T., Yoshimura, M., Miyata, A. & Tanabe, T
    • Organizer
      J. Pharmacol. Sci
    • Place of Presentation
      京都
    • Year and Date
      2012-03-15
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄痛覚伝達におけるGPR40の役割2012

    • Author(s)
      朝田俊秀、プラサンナ・カルキ、吉村惠、宮田篤郎、栗原崇
    • Organizer
      第9回GPCR研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neuro2a細胞におけるERストレスによるPAC1遺伝子の負の発現調節機序2012

    • Author(s)
      三浦綾子、神戸悠輝、井上和彦、栗原崇、宮田篤郎
    • Organizer
      第9回GPCR研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] PACAP-PAC1シグナルによる脊髄アストロサイトを介した疼痛制御2012

    • Author(s)
      大納哲也、長谷川麻衣子、栗原崇、上村裕一、宮田篤郎
    • Organizer
      第34回日本疼痛学会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脊髄痛覚伝達における脂肪酸受容体GPR40の役割2012

    • Author(s)
      栗原崇、カルキ・プラサンナ、朝田俊秀、吉村惠、宮田篤郎
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] Role of free fatty acid receptor GPR40 in mouse models of inflammatory and neuropathic pain2012

    • Author(s)
      Takashi Kurihara, Prasanna Karki, Toshihide Asada, Tetsuya Nagayama, Megumu Yoshimura, Kazunori Arita & Atsuro Miyata
    • Organizer
      Neuroscience 2012
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] PACAP誘発長期疼痛行動の発症メカニズム-PACAP-PAC1受容体シグナルによる早期脊髄後角アストロサイト活性化の関与2012

    • Author(s)
      用皆正文、大納哲也、栗原崇、長谷川麻衣子、朝田俊秀、上村裕一、清水隆雄、宮田篤郎
    • Organizer
      第65回日本薬理学会西南部会
    • Place of Presentation
      熊本
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脊髄痛覚情報伝達におけるカゼインキナーゼ 1 の役割2011

    • Author(s)
      栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 脊髄痛覚情報伝達におけるカゼインキナーゼ1の役割2011

    • Author(s)
      栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡大学メディカルホール福岡県
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] リゾホスファチジルセリンのラット下垂体由来細胞における成長ホルモン分泌への促進効果に関する研究2011

    • Author(s)
      國師恵美子、竹ノ内里奈、大和麻耶、井上和彦、神戸悠輝、栗原崇、宮田篤郎
    • Organizer
      第39回薬物活性シンポジウム
    • Place of Presentation
      福岡大学メディカルホール福岡県
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] カゼインキナーゼ 1δ/ε活性化は炎症性疼痛情報伝達に寄与する2011

    • Author(s)
      栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      福岡
    • Year and Date
      2011-11-20
    • Related Report
      2012 Final Research Report
  • [Presentation] カゼインキナーゼ1δ/ε活性化は炎症性疼痛情報伝達に寄与する2011

    • Author(s)
      栗原崇、櫻井絵里、朝田俊秀、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKRホテル博多、福岡県
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] PAC1受容体を介した神経突起形成メカニズムにおけるミトコンドリア機能調節2011

    • Author(s)
      神戸悠輝、井上和彦、栗原崇、宮田篤郎
    • Organizer
      第64回日本薬理学会西南部会
    • Place of Presentation
      KKRホテル博多、福岡県
    • Year and Date
      2011-11-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional analysis of N-arachidonoyl Glycine as a novel anti-inflammatory factor in microglia2011

    • Author(s)
      R.Takenouch, K.Inoue, Y.Kambe, T.Kurihara, A.Miyata
    • Organizer
      2011 Neuroscience Meeting (Society for Neuroscience, 2011)
    • Place of Presentation
      Walter E Washington Convention Center, Washington DC, USA
    • Year and Date
      2011-11-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 痛覚情報伝達におけるカゼインキナーゼ1活性化の意義2011

    • Author(s)
      栗原崇
    • Organizer
      The 5^<th> Anatomy and Developmental Biology Seminar
    • Place of Presentation
      京都大学、京都府(招待講演)
    • Year and Date
      2011-11-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] PACAPによる神経突起の形成過程におけるPgc1αの細胞内局在変化の関与2011

    • Author(s)
      神戸悠輝、井上和彦、栗原崇、宮田篤郎
    • Organizer
      第54回日本神経化学会大会
    • Place of Presentation
      瑠璃光、石川県
    • Year and Date
      2011-09-28
    • Related Report
      2011 Annual Research Report
  • [Presentation] Neuro2A細胞におけるERストレスによるPAC1遺伝子の負の発現調節機序2011

    • Author(s)
      三浦綾子、井上和彦、神戸悠輝、栗原崇、宮田篤郎
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 炎症性疼痛情報伝達におけるカゼインキナーゼ 1δ/ε 活性化の関与2011

    • Author(s)
      朝田俊秀、栗原崇、櫻井絵里、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第5回トランスポーター研究会九州部会
    • Place of Presentation
      宮崎
    • Year and Date
      2011-09-17
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性疼痛情報伝達におけるカゼインキナーゼ1δ/ε活性化の関与2011

    • Author(s)
      朝田俊秀、栗原崇、櫻井絵里、吉村惠、宮田篤郎、田邊勉
    • Organizer
      第5回トランスポーター研究会九州部会
    • Place of Presentation
      ホテルJALシティ宮崎宮崎県
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Lysophosphatidylserineはラット下垂体由来細胞において成長ホルモン分泌を促進させる2011

    • Author(s)
      竹ノ内里奈、國師恵美子、大和麻耶、井上和彦、神戸悠輝、栗原崇、宮田篤郎
    • Organizer
      第5回トランスポーター研究会九州部会
    • Place of Presentation
      ホテルJALシティ宮崎宮崎県
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] Activation of casein kinase 1δ/ε in dorsal root ganglia and spinal cord contributes to behavioral hypersensitivity induced by peripheral inflammation in mice2011

    • Author(s)
      Takashi Kurihaza, Eri Sakurai, Toshihide Asada, Atsuro Miyata, Tsutomu Tanabe
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord contributes to neuropathic pain induced by spinal nerve ligation in mice2011

    • Author(s)
      Eri Sakurai, Takashi Kurihara, Atsuro Miyata, Tsutomu Tanabe
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Pgc1 translocation may be one of the key factors for neurite extension in Neuro2a cells2011

    • Author(s)
      Yuki Kambe, Kazuhiko Inoue, Takashi Kurihara, Atsuro Miyata
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] Mechanism of the negative regulation of PAC1 gene expression2011

    • Author(s)
      Ayako Miura, Kazuhiko Inoue, Yuki Kambe, Takashi Kurihara, Atsuro Miyata
    • Organizer
      第84回日本薬理学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] On the role of casein kinase 1 in mouse models of inflammatory and neuropathic pain2011

    • Author(s)
      Takashi Kurihara, Eri Sakurai, Toshihide Asada, Megumu Yoshimura, Atsuro Miyata, Tsutomu Tanabe
    • Organizer
      The 85^<th> Annual meeting of the Japanese Pharmacological Society
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2011-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Apoptosis of macrophages by N-arachidonoyl glycine is mediated by GPR182011

    • Author(s)
      Rina Takenouch, Kazuhiko Inoue, Yuki Kambe, Takashi Kurihara, Atsuro Miyata
    • Organizer
      The 85^<th> Annual meeting of the Japanese Pharmacological Society
    • Place of Presentation
      国立京都国際会館、京都府
    • Year and Date
      2011-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord contributes to neuropathic pain induced by spinal nerve ligation in mice2011

    • Author(s)
      Sakurai, E., Kurihara, T.,, Miyata, A. & Tanabe, T
    • Organizer
      J. Pharmacol. Sci
    • Place of Presentation
      雑誌上での誌上開催
    • Related Report
      2012 Final Research Report
  • [Presentation] Activation of casein kinase 1δ/ε in dorsal root ganglia and spinal cord contributes to behavioral hypersensitivity induced by peripheral inflammation in mice2011

    • Author(s)
      Kurihara, T., Sakurai, E., Asada, T., Miyata, A. & Tanabe, T
    • Organizer
      J. Pharmacol. Sci
    • Place of Presentation
      雑誌上での誌上開催
    • Related Report
      2012 Final Research Report
  • [Presentation] Implication of pituitary adenylate cyclase-activating polypeptide(PACAP) in diabetic neuropathy of streptozotocin(STZ) treated mice2010

    • Author(s)
      Atsuro Miyata, Keigo Ikeda, Kazuhiko Inoue, Takashi Kurihara, Takao Shimizu
    • Organizer
      5th International Peptide Symposium
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] 中枢神経への高脂肪食の影響に関与する受容体の解析2010

    • Author(s)
      新川純平、神戸悠輝、井上和彦、栗原崇、武田泰生、山田勝士、宮田篤郎
    • Organizer
      第63回 日本薬理学会西南部会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] PC12細胞におけるPAC1遺伝子の負の発現調節機序2010

    • Author(s)
      三浦綾子、富永愛子、井上和彦、神戸悠輝、栗原崇、宮田篤郎
    • Organizer
      第63回 日本薬理学会西南部会
    • Place of Presentation
      鹿児島
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Implication of pituitary adenylate cyclase-activating polypeptide (PACAP) in diabetic neuropathy of streptozotocin (STZ) treated mice2010

    • Author(s)
      Atsuro Miyata, Keigo Ikeda, Kazuhiko Inoue, Takashi Kurihara, Takao Shimizu
    • Organizer
      The 20^<th> Japan-Korea Joint Seminar on Pharmacology
    • Place of Presentation
      Kagoshima, Japan
    • Year and Date
      2010-11-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] Inhibitors of casein kinase 1 epsilon are effective in blocking pain in neuropathic mice without showing any appreciable side effect in normal mice2010

    • Author(s)
      T.TANABE, E.SAKURAI, T.KURIHARA, K.KOUCHI, H.SAEGUSA, S.ZONG
    • Organizer
      2010 Neuroscience Meeting(Society for Neuroscience, 2010)
    • Place of Presentation
      San Diego, CA, USA
    • Year and Date
      2010-11-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 神経因性疹痛発症におけるGi/oタンパク質情報伝達系の役割2010

    • Author(s)
      栗原崇、塩飽裕紀、田邊勉
    • Organizer
      第7回 GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] PACAP-PAC1受容体シグナルによる早期脊髄アストロサイト活性化は、PACAP誘発長期疼痛行動に寄与する

    • Author(s)
      用皆正文、大納哲也、栗原崇、長谷川麻衣子、朝田俊秀、上村裕一、清水隆雄、宮田篤郎
    • Organizer
      第6回トランスポーター研究会九州部会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2012 Final Research Report
  • [Remarks] 生体情報薬理学分野ホームページ

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.kufm.kagoshima-u.ac.jp/~pharmaco/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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