A new pain-related protein kinase signal transduction map: an analysis by phosphor proteomics
Project/Area Number |
22600001
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
疼痛学
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Research Institution | Kagoshima University |
Principal Investigator |
KURIHARA Takashi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (60282745)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 痛み / プロテオーム / シグナル伝達 / 脊髄 / リン酸化酵素 / ホールセルパッチクランプ / 後根神経節 / ホールセルパッチクランプ記録 / カゼインキナーゼ1 / CK1阻害薬 / 酵素 / 脳・神経 |
Research Abstract |
We have suggested that CK1δ/ε play important physiological roles in both neuropathic and inflammatory pain signaling, which makes them useful targets for analgesic drug development. We have also identified several potential new CK1 inhibitors. TG003, one of these candidates, was suggested to have potent inhibitory effects on CK1 isoforms in vitro, and showed antinociceptive effects on acute and persistent inflammatory pain models in mice. Our data indicate that TG003 might be a promising lead compound for the development of CK1-targeted new analgesic drugs .
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells.2012
Author(s)
Miura, A., Odahara, N., Tominaga, A., Inoue, K., Kambe, Y., Kurihara, T. & Miyata, A.
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Journal Title
FEBS Lett.
Volume: 586
Issue: 12
Pages: 1731-1735
DOI
Related Report
Peer Reviewed
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[Journal Article] Upregulation of casein kinase 1ε in dorsal root ganglia and spinal cord after mouse spinal nerve injury contributes to neuropathic pain2009
Author(s)
Sakurai, E., Kurihara, T., Kouchi, K., Saegusa, H., Zong, S & Tanabe, T
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Journal Title
Mol. Pain
Volume: 5
Pages: 74-74
DOI
Related Report
Peer Reviewed
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[Presentation] On the role of casein kinase 1 in mouse models of inflammatory and neuropathic pain2012
Author(s)
Kurihara, T., Sakurai, E., Asada, T., Yoshimura, M., Miyata, A. & Tanabe, T
Organizer
J. Pharmacol. Sci
Place of Presentation
京都
Year and Date
2012-03-15
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