| Project/Area Number |
22611005
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical Physics/Radiological Technology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MASUTANI Yoshitaka 東京大学, 医学部附属病, 講師 (20345193)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Keywords | コンピュータ支援診断 / MRI / 動脈硬化 / 脳神経疾患 |
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| Research Abstract |
The aim of this study is to develop a biomarker of atherosclerosis by computer-assisted shape analysis of cerebral arteries from MRA data.First, we analyzed pilot data of 10 cases using multiscale morphological approach. We defined a feature value that caused a significant difference between a control group and an atherosclerosis group, as “shape regularity index of vessel (SRIV)”.Second, 51 cases were selected as a validation data set and divided into three groups by visual evaluation of vessel wall (Grade 0: no irregularity, Grade 1: mild irregularity, Grade 2: severe irregularity). A significant difference was found in SRIV value between Grade 0 and 1, and between Grade 1 and 2.We concluded that SRIV value had a correlation with vessel wall irregularity evaluated visually, and this value would be an objective biomarker of atherosclerosis.
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