MRI quantification of cerebral blood flow and oxygen metabolism at rest and during task performance --- to elucidate the sensing mechanism of fatigue in the brain
Project/Area Number |
22613003
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Non-invasive neuroimaging
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
TOYODA Hiroshi 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (10558084)
|
Project Period (FY) |
2010 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
|
Keywords | MRI / 局所脳血流量 / 疲労 |
Research Abstract |
The purpose of this study was to develop a non-invasive method for functional brain imaging both at rest and during tasks, in order to elucidate the sensing mechanisms of fatigue in the human brain. Healthy subjects were measured by a newly developed MRI-based spin labeling methods to quantify cerebral blood flow and oxygen extraction fraction at baseline. The pulse sequences for arterial spin labeling were optimized using multi-slab 3D acquisitions, the measurement accuracy of which was validated. The feasibility of the proposed method was demonstrated by its better time efficiency without sacrificing quantification accuracy.
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Report
(4 results)
Research Products
(6 results)