MRI quantification of cerebral blood flow and oxygen metabolism at rest and during task performance --- to elucidate the sensing mechanism of fatigue in the brain

• Project/Area Number: 22613003
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Non-invasive neuroimaging
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TOYODA Hiroshi 独立行政法人理化学研究所, 分子プローブ動態応用研究チーム, 研究員 (10558084)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: MRI / 局所脳血流量 / 疲労

Research Abstract

The purpose of this study was to develop a non-invasive method for functional brain imaging both at rest and during tasks, in order to elucidate the sensing mechanisms of fatigue in the human brain. Healthy subjects were measured by a newly developed MRI-based spin labeling methods to quantify cerebral blood flow and oxygen extraction fraction at baseline. The pulse sequences for arterial spin labeling were optimized using multi-slab 3D acquisitions, the measurement accuracy of which was validated. The feasibility of the proposed method was demonstrated by its better time efficiency without sacrificing quantification accuracy.

Research Products

• [Journal Article] Suppression of brain activity related to a car-following task with an auditory task: An fMRI study (2012)
  • Author(s): Uchiyama Y, Toyoda H, Sakai H, Shin D, Ebe K, Sadato N
  • Journal Title: Transportation Research Part F: Traffic Psychology and Behaviour Volume: 15(1) Pages: 25-37
  • Peer Reviewed
• [Journal Article] Suppression of brain activity related to a car-following task with an auditory task : An fMRI study (2012)
  • Author(s): Uchiyama Y, Toyoda H, Sakai H, Shin D., Ebe K, Sadato N
  • Journal Title: Transportation Research Part F Volume: 15 Issue: 1 Pages: 25-37
  • DOI: 10.1016/j.trf.2011.11.002
  • Peer Reviewed
• [Presentation] Interleaved multi-slab 3D gradient and spin echo for arterial spin labeling (2013)
  • Author(s): Hiroshi Toyoda, Guoxian Liu, Yusuke Morito, Yasuyoshi Watanabe
  • Organizer: ISMRM 21th Annual Meeting & Exhibition.
  • Place of Presentation: Lake City, USA
• [Presentation] Interleaved multi-slab 3D gradient and spin echo for arterial spin labeling (2013)
  • Author(s): Hiroshi Toyoda, Guoxian Liu, Yusuke Morito, Yasuyoshi Watanabe
  • Organizer: ISMRM 21th Annual Meeting & Exhibition
  • Place of Presentation: Salt Lake City，USA
• [Presentation] Automatic segmentation method using T1- and T2-weighted images without any tissue probability maps (2010)
  • Author(s): Hiroshi Toyoda, Yasuyoshi Watanabe
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Barcerona, Spain
• [Presentation] Automatic segmentation method using T1- and T2-weighted images without any tissue probability maps (2010)
  • Author(s): Hiroshi Toyoda
  • Organizer: 16th Annual Meeting of the Organization for Human Brain Mapping
  • Place of Presentation: バルセロナ