| Project/Area Number |
22650130
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Single-year Grants |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Nagasaki University |
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Principal Investigator |
OKITA Minoru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (50244091)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAMOTO Jyunya 長崎大学, 大学病院, 理学療法士 (20584080)
NAKANO Jiro 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (20380834)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,320,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,500,000 (Direct Cost: ¥1,500,000)
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| Keywords | 変形性膝関節症 / 痛み / 運動療法 / 持続的他動運動 / 筋力トレーニング / 抗炎症性サイトカイン / 実験モデル / 関節炎 / 筋収縮運動 / 炎症 / 腫脹 / 痛覚閾値 / 慢性痛 / CPM / 電気刺激 / 二次痛覚過敏 |
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| Research Abstract |
The objective of this study is to present the basic data for biological effects of therapeutic exercise on osteoarthritis of knee. We simulated two kinds of therapeutic exercises like continuous passive motion and low-intensity exercise by neuromuscular electrical stimulation, and examined the effects of therapeutic exercisesduring the early stages of arthritis on inflammation and pain-related behavior in rat’sarthritis model. As a result, therapeutic exercises significantly accelerated the amelioration of joint swelling and pressure withdrawal threshold and increased the mechanical withdrawal threshold immediately after treatment. We hypothesized that the mechanism of such a biological effect by therapeutic exercise related to the up-regulation of anti-inflammatory cytokine on surrounding tissue of joint. Additionally, we assumed that anti-inflammatory cytokine was able to use as the biomarker.
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